Combinatorial network of transcriptional regulation and microRNA regulation in human cancer

BMC Systems Biology

Table 3 Validation of regulation relationships

Regulation type	Validation source	Engineering method	Total items	Items validated	Validation fraction	Significance of validation fraction increase (binomial test p-value)
miRNA-to-gene	TarBase	Forward	86,196	583	0.6%	<0.055
		Forward and reverse	1,625	16	1%
TF-to-gene	TransFAC	Forward	58,417	137	0.3%	3.3e-13
		Forward and reverse	3,413	35	1%
TF-to-miRNA	TransmiR	Forward	1195	23	1.9%	1.8e-5
		Forward and reverse	98	9	9.1%

*Forward: the forward-predicted regulatory relationships involving only the regulators showing up in the combinatorial regulatory network; forward and reverse: the regulatory relationships showing up in the combinatorial regulatory network.

ISSN: 1752-0509