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Table 1 Ataxic mouse models relevant to this study

From: Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia

Ataxia model Mutated gene product Protein name Pathology Compensation *Observed/**Suggested Therapeutic
 BK -/- BK Large conductance calcium-activated voltage-gated potassium channel Altered Precision Timing ---
IP3R1 -/- IP3R1 Inositol triphosphate receptor 1 No IP3R1 --
IP3R1 +/- IP3R1 Inositol triphosphate receptor 1 R S**
IP3R1 delta18/delta18 IP3R1 Inositol triphosphate receptor 1 R S**
IP3R1 opt/opt IP3R1 Inositol triphosphate receptor 1 R Equivocal
 SCA15 IP3R1 Inositol triphosphate receptor 1 R S**
 SCA16 IP3R1 Inositol triphosphate receptor 1 R S**
 PMCA -/- PMCA Plasma Membrane Calcium ATPase No PCMA R*
 SCA1 Ataxin1 Ataxin-1 P,A,I R*
 SCA2 Ataxin2 Ataxin-2 P,A,S,I R**
 SCA3 Ataxin3 Ataxin-3 P,A,S,I R*
  1. P = Polyglutamine expansion; S = Supersensitive IP3R1; A = Association of mutant Ataxin with IP3R1 C-terminal; R = Reduced IP3R1 abundance; I = Increased calcium release.