Table 2 Optimal Values of Parameters Used to Describe the Network

Cdc6 production

k₁

15.982

(Mol./cell) x min^-1

Cdc6 degradation

k₂

0.001

(Mol./cell)^-1 x min^-1

Dbf4 production

k₃

1368.220

(Mol./cell) x min^-1

Dbf4 degradation

k₄

2.440

(Mol./cell)^-1 x min^-1

Cdc6 association with ORC

k₅

0.016

(Mol./cell)^-1 x min^-1

Cdc6 dissociation from ORC

k_5r

675.422

min^-1

MCM-Cdt1 import

k₆

1.015

(Mol./cell)^-1 x min^-1

MCM loading

k₇

275.675

(Mol./cell)^-1 x min^-1

Cdt1 export

k₈

1.732

(Mol./cell)^-1 x min^-1

Dissociation of MCM·Cdt1

k₉

100.881

min^-1

Re-association of MCM·Cdt1

k_9r

1042.739

(Mol./cell)^-1 x min^-1

Dissociation of Cdc6 from RC3

k₁₀

936.745

min^-1

Re-association of Cdc6 with RC3

k_10r

352.504

(Mol./cell)^-1 x min^-1

Unloading of MCM from RC4

k₁₁

885.147

min^-1

Dbf4 association with RC4

k₁₂

0.568

(Mol./cell)^-1 x min^-1

Dbf4 dissociation with RC4

k_12r

192.628

min^-1

Association of Cdc45 with RC5

k₁₃

0.528

(Mol./cell)^-1 x min^-1

Fork Firing

k₁₄

0.237

min^-1

Fork disassembly

k₁₅

0.097

min^-1

MCM export

k₁₆

3.196

min^-1

Phosphorylation of ORC

k₁₇

13.313

min^-1

Dephosphorylation of ORC

k₁₈

2.497

Mol./cell

Michealis constant for import of MCM

KM₁

195.302

Mol./cell

Michealis constant for association of Cdc45

KM₂

8.248

Mol./cell