Bell SP, Stillman B: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 1992,357(6374):128-134.
Article
Google Scholar
Rao H, Stillman B: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. Proc Natl Acad Sci U S A 1995,92(6):2224-2228.
Article
Google Scholar
Rowley A, Cocker JH, Harwood J, Diffley JF: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J 1995,14(11):2631-2641.
Google Scholar
Tanaka S, Umemori T, Hirai K, Muramatsu S, Kamimura Y, Araki H: CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 2007,445(7125):328-332.
Article
Google Scholar
Speck C, Chen Z, Li H, Stillman B: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA. Nat Struct Mol Biol 2005,12(11):965-971.
Article
Google Scholar
Speck C, Stillman B: Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J Biol Chem 2007,282(16):11705-11714.
Article
Google Scholar
Tanaka S, Diffley JF: Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 2002,4(3):198-207.
Article
Google Scholar
Semple JW, Da-Silva LF, Jervis EJ, Ah-Kee J, Al-Attar H, Kummer L, Heikkila JJ, Pasero P, Duncker BP: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes. EMBO J 2006,25(21):5150-5158.
Article
Google Scholar
Chen S, de Vries MA, Bell SP: Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes Dev 2007,21(22):2897-2907.
Article
Google Scholar
Randell JC, Bowers JL, Rodriguez HK, Bell SP: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell 2006,21(1):29-39.
Article
Google Scholar
Bowers JL, Randell JC, Chen S, Bell SP: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication. Mol Cell 2004,16(6):967-978.
Article
Google Scholar
Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C: A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Natl Acad Sci U S A 2009,106(48):20240-20245.
Article
Google Scholar
Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF: Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 2009,139(4):719-730.
Article
Google Scholar
Lei M, Kawasaki Y, Young MR, Kihara M, Sugino A, Tye BK: Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 1997,11(24):3365-3374.
Article
Google Scholar
Sheu YJ, Stillman B: Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression. Mol Cell 2006,24(1):101-113.
Article
Google Scholar
Francis LI, Randell JC, Takara TJ, Uchima L, Bell SP: Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. Genes Dev 2009,23(5):643-654.
Article
Google Scholar
Randell JC, Fan A, Chan C, Francis LI, Heller RC, Galani K, Bell SP: Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell 2010,40(3):353-363.
Article
Google Scholar
Sheu YJ, Stillman B: The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4. Nature 2010,463(7277):113-117.
Article
Google Scholar
Zachariae W, Nasmyth K: Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 1999,13(16):2039-2058.
Article
Google Scholar
Cheng L, Collyer T, Hardy CF: Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 1999,19(6):4270-4278.
Article
Google Scholar
Oshiro G, Owens JC, Shellman Y, Sclafani RA, Li JJ: Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability. Mol Cell Biol 1999,19(7):4888-4896.
Article
Google Scholar
Ferreira MF, Santocanale C, Drury LS, Diffley JF: Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Mol Cell Biol 2000,20(1):242-248.
Article
Google Scholar
Eytan E, Moshe Y, Braunstein I, Hershko A: Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc Natl Acad Sci U S A 2006,103(7):2081-2086.
Article
Google Scholar
Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, Labib K: GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 2006,8(4):358-366.
Article
Google Scholar
Kanemaki M, Labib K: Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks. EMBO J 2006,25(8):1753-1763.
Article
Google Scholar
Zegerman P, Diffley JF: Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007,445(7125):281-285.
Article
Google Scholar
Bruck I, Kaplan DL: Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2-7 Complex, Allowing the GINS Tetramer to Bind the Mcm2-7 Complex. J Biol Chem 2011,286(21):18602-18613.
Article
Google Scholar
Dutta A, Bell SP: Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol 1997, 13: 293-332.
Article
Google Scholar
Elsasser S, Chi Y, Yang P, Campbell JL: Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol Biol Cell 1999,10(10):3263-3277.
Article
Google Scholar
Drury LS, Perkins G, Diffley JF: The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle. Curr Biol 2000,10(5):231-240.
Article
Google Scholar
Drury LS, Perkins G, Diffley JF: The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J 1997,16(19):5966-5976.
Article
Google Scholar
Nguyen VQ, Co C, Li JJ: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature 2001,411(6841):1068-1073.
Article
Google Scholar
Vas A, Mok W, Leatherwood J: Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex. Mol Cell Biol 2001,21(17):5767-5777.
Article
Google Scholar
Wilmes GM, Archambault V, Austin RJ, Jacobson MD, Bell SP, Cross FR: Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes Dev 2004,18(9):981-991.
Article
Google Scholar
Chen S, Bell SP: CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6. Genes Dev 2011,25(4):363-372.
Article
Google Scholar
Labib K, Diffley JF, Kearsey SE: G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat Cell Biol 1999,1(7):415-422.
Article
Google Scholar
Nguyen VQ, Co C, Irie K, Li JJ: Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr Biol 2000,10(4):195-205.
Article
Google Scholar
Liku ME, Nguyen VQ, Rosales AW, Irie K, Li JJ: CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell 2005,16(10):5026-5039.
Article
Google Scholar
Kauffman S, Wille JJ: The mitotic oscillator in Physarum polycephalum. J Theor Biol 1975,55(1):47-93.
Article
Google Scholar
Hyver C, Le Guyader H: MPF and cyclin: modelling of the cell cycle minimum oscillator. Biosystems 1990,24(2):85-90.
Article
Google Scholar
Goldbeter A: A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase. Proc Natl Acad Sci U S A 1991,88(20):9107-9111.
Article
Google Scholar
Tyson JJ: Modeling the cell division cycle: cdc2 and cyclin interactions. Proc Natl Acad Sci U S A 1991,88(16):7328-7332.
Article
Google Scholar
Norel R, Agur Z: A model for the adjustment of the mitotic clock by cyclin and MPF levels. Science 1991,251(4997):1076-1078.
Article
Google Scholar
Li F, Long T, Lu Y, Ouyang Q, Tang C: The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A 2004,101(14):4781-4786.
Article
Google Scholar
Chen KC, Calzone L, Csikasz-Nagy A, Cross FR, Novak B, Tyson JJ: Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell 2004,15(8):3841-3862.
Article
Google Scholar
Chen KC, Csikasz-Nagy A, Gyorffy B, Val J, Novak B, Tyson JJ: Kinetic analysis of a molecular model of the budding yeast cell cycle. Mol Biol Cell 2000,11(1):369-391.
Article
Google Scholar
Klipp E, Nordlander B, Kruger R, Gennemark P, Hohmann S: Integrative model of the response of yeast to osmotic shock. Nat Biotechnol 2005,23(8):975-982.
Article
Google Scholar
Ingalls BP, Duncker BP, Kim DR, McConkey BJ: Systems level modeling of the cell cycle using budding yeast. Cancer Inform 2007, 3: 357-370.
Google Scholar
Alarcon T, Tindall MJ: Modelling cell growth and its modulation of the G1/S transition. Bull Math Biol 2007,69(1):197-214.
Article
Google Scholar
Barberis M, Klipp E, Vanoni M, Alberghina L: Cell size at S phase initiation: an emergent property of the G1/S network. PLoS Comput Biol 2007,3(4):e64.
Article
Google Scholar
Spiesser TW, Klipp E, Barberis M: A model for the spatiotemporal organization of DNA replication in Saccharomyces cerevisiae. Mol Genet Genomics 2009,282(1):25-35.
Article
Google Scholar
de Moura AP, Retkute R, Hawkins M, Nieduszynski CA: Mathematical modelling of whole chromosome replication. Nucleic Acids Res 2010,38(17):5623-5633.
Article
Google Scholar
Retkute R, Nieduszynski CA, de Moura A: Dynamics of DNA replication in yeast. Phys Rev Lett 2011,107(6):068103.
Article
Google Scholar
Brummer A, Salazar C, Zinzalla V, Alberghina L, Hofer T: Mathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplication. PLoS Comput Biol 2010,6(5):e1000783.
Article
Google Scholar
Tanaka S, Nakato R, Katou Y, Shirahige K, Araki H: Origin association of sld3, sld7, and cdc45 proteins is a key step for determination of origin-firing timing. Curr Biol 2011,21(24):2055-2063.
Article
Google Scholar
Mantiero D, Mackenzie A, Donaldson A, Zegerman P: Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast. EMBO J 2011,30(23):4805-4814.
Article
Google Scholar
Donovan S, Harwood J, Drury LS, Diffley JF: Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 1997,94(11):5611-5616.
Article
Google Scholar
Lei M, Kawasaki Y, Tye BK: Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae. Mol Cell Biol 1996,16(9):5081-5090.
Article
Google Scholar
Aparicio OM, Weinstein DM, Bell SP: Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 1997,91(1):59-69.
Article
Google Scholar
Gibson DG, Bell SP, Aparicio OM: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 2006,11(6):557-573.
Article
Google Scholar
Hopwood B, Dalton S: Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc Natl Acad Sci U S A 1996,93(22):12309-12314.
Article
Google Scholar
Owens JC, Detweiler CS, Li JJ: CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc Natl Acad Sci U S A 1997,94(23):12521-12526.
Article
Google Scholar
Liang C, Stillman B: Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev 1997,11(24):3375-3386.
Article
Google Scholar
Forsburg SL: Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev 2004,68(1):109-131.
Article
Google Scholar
Raghuraman MK, Winzeler EA, Collingwood D, Hunt S, Wodicka L, Conway A, Lockhart DJ, Davis RW, Brewer BJ, Fangman WL: Replication dynamics of the yeast genome. Science 2001,294(5540):115-121.
Article
Google Scholar
Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK: Global analysis of protein localization in budding yeast. Nature 2003,425(6959):686-691.
Article
Google Scholar
Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS: Global analysis of protein expression in yeast. Nature 2003,425(6959):737-741.
Article
Google Scholar
Poddar A, Stukenberg PT, Burke DJ: Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae. Eukaryot Cell 2005,4(5):867-878.
Article
Google Scholar
Schreiber A, Stengel F, Zhang Z, Enchev RI, Kong EH, Morris EP, Robinson CV, da Fonseca PC, Barford D: Structural basis for the subunit assembly of the anaphase-promoting complex. Nature 2011,470(7333):227-232.
Article
Google Scholar
Longtine MS, McKenzie A, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR: Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998,14(10):953-961.
Article
Google Scholar
Pasero P, Duncker BP, Schwob E, Gasser SM: A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication. Genes Dev 1999,13(16):2159-2176.
Article
Google Scholar
Gadkar KG, Gunawan R, Doyle FJ: Iterative approach to model identification of biological networks. BMC Bioinforma 2005, 6: 155.
Article
Google Scholar
Jones DR, Prasad AA, Chan PK, Duncker BP: The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress. Cell Cycle 2010,9(10):2018-2026.
Article
Google Scholar
Zou L, Mitchell J, Stillman B: CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol Cell Biol 1997,17(2):553-563.
Article
Google Scholar
Yu H: Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol 2002,14(6):706-714.
Article
Google Scholar
Goldar A, Marsolier-Kergoat MC, Hyrien O: Universal temporal profile of replication origin activation in eukaryotes. PLoS One 2009,4(6):e5899.
Article
Google Scholar
McCune HJ, Danielson LS, Alvino GM, Collingwood D, Delrow JJ, Fangman WL, Brewer BJ, Raghuraman MK: The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae. Genetics 2008,180(4):1833-1847.
Article
Google Scholar
Hyrien O, Marheineke K, Goldar A: Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem. Bioessays 2003,25(2):116-125.
Article
Google Scholar
Green BM, Morreale RJ, Ozaydin B, Derisi JL, Li JJ: Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell 2006,17(5):2401-2414.
Article
Google Scholar
Chassagnole C, Jackson RC, Hussain N, Bashir L, Derow C, Savin J, Fell DA: Using a mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development. Biosystems 2006,83(2–3):91-97.
Article
Google Scholar
Gerard C, Goldbeter A: From simple to complex patterns of oscillatory behavior in a model for the mammalian cell cycle containing multiple oscillatory circuits. Chaos 2010,20(4):045109.
Article
Google Scholar
Novak B, Tyson JJ: A model for restriction point control of the mammalian cell cycle. J Theor Biol 2004,230(4):563-579.
Article
Google Scholar
Qu Z, Weiss JN, MacLellan WR: Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol 2003,284(2):C349-C364.
Article
Google Scholar
Swat M, Kel A, Herzel H: Bifurcation analysis of the regulatory modules of the mammalian G1/S transition. Bioinformatics 2004,20(10):1506-1511.
Article
Google Scholar
Lau E, Jiang W: Is there a pre-RC checkpoint that cancer cells lack? Cell Cycle 2006,5(15):1602-1606.
Article
Google Scholar
Gavin EJ, Song B, Wang Y, Xi Y, Ju J: Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin. PLoS One 2008,3(12):e4054.
Article
Google Scholar
Gonzalez MA, Tachibana KE, Laskey RA, Coleman N: Control of DNA replication and its potential clinical exploitation. Nat Rev Cancer 2005,5(2):135-141.
Article
Google Scholar
Bicknell LS, Bongers EM, Leitch A, Brown S, Schoots J, Harley ME, Aftimos S, Al-Aama JY, Bober M, Brown PA, van Bokhoven H, Dean J, Edrees AY, Feingold M, Fryer A, Hoefsloot LH, Kau N, Knoers NV, Mackenzie J, Opitz JM, Sarda P, Ross A, Temple IK, Toutain A, Wise CA, Wright M, Jackson AP: Mutations in the pre-replication complex cause Meier-Gorlin syndrome. Nat Genet 2011,43(4):356-359.
Article
Google Scholar
Bicknell LS, Walker S, Klingseisen A, Stiff T, Leitch A, Kerzendorfer C, Martin CA, Yeyati P, Al Sanna N, Bober M, Johnson D, Wise C, Jackson AP, O’Driscoll M, Jeggo PA: Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat Genet 2011,43(4):350-355.
Article
Google Scholar
Nieduszynski CA, Knox Y, Donaldson AD: Genome-wide identification of replication origins in yeast by comparative genomics. Genes Dev 2006,20(14):1874-1879.
Article
Google Scholar
Feng W, Collingwood D, Boeck ME, Fox LA, Alvino GM, Fangman WL, Raghuraman MK, Brewer BJ: Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication. Nat Cell Biol 2006,8(2):148-155.
Article
Google Scholar
Wyrick JJ, Aparicio JG, Chen T, Barnett JD, Jennings EG, Young RA, Bell SP, Aparicio OM: Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science 2001,294(5550):2357-2360.
Article
Google Scholar
Varrin AE, Prasad AA, Scholz RP, Ramer MD, Duncker BP: A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents. Mol Cell Biol 2005,25(17):7494-7504.
Article
Google Scholar
Yan H, Gibson S, Tye BK: Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes Dev 1991,5(6):944-957.
Article
Google Scholar
Yan H, Merchant AM, Tye BK: Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev 1993,7(11):2149-2160.
Article
Google Scholar
Detweiler CS, Li JJ: Cdc6p establishes and maintains a state of replication competence during G1 phase. J Cell Sci 1997,110(Pt 6):753-763.
Google Scholar
Bousset K, Diffley JF: The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev 1998,12(4):480-490.
Article
Google Scholar