Figure 10

Sensitivity Analysis. Concentration control coefficients from sensitivity analysis. (Left panel) Concentration control coefficients (CCCs) for ACI# with respect to the degradation rates of the mRNA for the slip bond model for 300 different parameter sets. Both, for the Rac-IC as well as for the Rho-IC a knockdown of integrin would be most effective for the majority of the parameter sets. Nevertheless, there are parameter sets for which a knockdown of actin would yield the best results. The effectivity of the knockdown of the connector species remains constant for Rac-IC. For most parameter sets the focal adhesions are more stable for Rho-IC. (Right panel) Results for the catch bond model. For Rac-IC the result is comparable to the slip bond model. For Rho-IC, the absolute values of the CCCs are much smaller, indicating that the focal adhesions are much more stable if we assume catch bond behavior.