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Table 1 Summary of the drugs, targets, and their interactions in six data sources and their overlap

From: A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case

   Overlap (numbera/proportionb)
  Source DrugBank KEGG TTD MATADOR PDSP BindingDB
Drug DrugBank 4,316 0.679 0.369 0.590 0.045 0.269
  KEGG 761 1,121 0.467 0.550 0.135 0.231
  TTD 1,594 524 14,073 0.405 0.069 0.425
  MATADOR 447 417 307 758 0.199 0.170
  PDSP 195 151 340 151 4,947 0.004
  BindingDB 1,162 259 5,984 129 22 290,874
Target DrugBank 2,102 0.622 0.510 0.108 0.324 0.182
  KEGG 295 474 0.418 0.409 0.283 0.348
  TTD 479 198 940 0.113 0.434 0.526
  MATADOR 198 194 106 1,840 0.262 0.040
  PDSP 47 41 63 38 145 0.152
  BindingDB 372 165 494 73 22 2,048
Drug-target DrugBank 9,886 0.440 0.200 0.092 0.039 0.149
  KEGG 1,553 3,532 0.166 0.254 0.067 0.117
  TTD 1,976 586 22,791 0.032 0.042 0.386
  MATADOR 906 898 341 10,687 0.023 0.017
  PDSP 384 237 490 247 11,762 0.007
  BindingDB 1,471 415 8,804 179 81 503,378
  1. aThe value on the diagonal line of each matrix represents the numbers of drug/target/drug-target pair in each source. The value under the diagonal line of each matrix shows the number of overlap between two sources.
  2. bThe value above the diagonal line of each matrix shows the proportions of overlap between two sources. The proportion is defined as the number of intersection dividing by the smaller number of the two sources.