A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case

BMC Systems Biology

Table 1 Summary of the drugs, targets, and their interactions in six data sources and their overlap

		Overlap (number^a/proportion^b)
	Source	DrugBank	KEGG	TTD	MATADOR	PDSP	BindingDB
Drug	DrugBank	4,316	0.679	0.369	0.590	0.045	0.269
	KEGG	761	1,121	0.467	0.550	0.135	0.231
	TTD	1,594	524	14,073	0.405	0.069	0.425
	MATADOR	447	417	307	758	0.199	0.170
	PDSP	195	151	340	151	4,947	0.004
	BindingDB	1,162	259	5,984	129	22	290,874
Target	DrugBank	2,102	0.622	0.510	0.108	0.324	0.182
	KEGG	295	474	0.418	0.409	0.283	0.348
	TTD	479	198	940	0.113	0.434	0.526
	MATADOR	198	194	106	1,840	0.262	0.040
	PDSP	47	41	63	38	145	0.152
	BindingDB	372	165	494	73	22	2,048
Drug-target	DrugBank	9,886	0.440	0.200	0.092	0.039	0.149
	KEGG	1,553	3,532	0.166	0.254	0.067	0.117
	TTD	1,976	586	22,791	0.032	0.042	0.386
	MATADOR	906	898	341	10,687	0.023	0.017
	PDSP	384	237	490	247	11,762	0.007
	BindingDB	1,471	415	8,804	179	81	503,378

^aThe value on the diagonal line of each matrix represents the numbers of drug/target/drug-target pair in each source. The value under the diagonal line of each matrix shows the number of overlap between two sources.
^bThe value above the diagonal line of each matrix shows the proportions of overlap between two sources. The proportion is defined as the number of intersection dividing by the smaller number of the two sources.

ISSN: 1752-0509