Boran AD, Iyengar R: Systems pharmacology. Mt Sinai J Med. 2010, 77 (4): 333-344. 10.1002/msj.20191.
Article
PubMed Central
PubMed
Google Scholar
Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates?. Nature reviews Drug discovery. 2004, 3 (8): 711-715. 10.1038/nrd1470.
Article
CAS
PubMed
Google Scholar
Iskar M, Zeller G, Zhao XM, van Noort V, Bork P: Drug discovery in the age of systems biology: the rise of computational approaches for data integration. Current opinion in biotechnology. 2012, 23 (4): 609-616. 10.1016/j.copbio.2011.11.010.
Article
CAS
PubMed
Google Scholar
Berger SI, Iyengar R: Network analyses in systems pharmacology. Bioinformatics. 2009, 25 (19): 2466-2472. 10.1093/bioinformatics/btp465.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ashburn TT, Thor KB: Drug repositioning: identifying and developing new uses for existing drugs. Nature reviews Drug discovery. 2004, 3 (8): 673-683. 10.1038/nrd1468.
Article
CAS
PubMed
Google Scholar
Hurle MR, Yang L, Xie Q, Rajpal DK, Sanseau P, Agarwal P: Computational drug repositioning: from data to therapeutics. Clinical pharmacology and therapeutics. 2013, 93 (4): 335-341. 10.1038/clpt.2013.1.
Article
CAS
PubMed
Google Scholar
Yang L, Agarwal P: Systematic drug repositioning based on clinical side-effects. PloS one. 2011, 6 (12): e28025-10.1371/journal.pone.0028025.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sanseau P, Agarwal P, Barnes MR, Pastinen T, Richards JB, Cardon LR, Mooser V: Use of genome-wide association studies for drug repositioning. Nature biotechnology. 2012, 30 (4): 317-320. 10.1038/nbt.2151.
Article
CAS
PubMed
Google Scholar
Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, Zmoos AF, Vaka D, Tran KQ, Zhou M, et al: A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer discovery. 2013, 3 (12): 1364-1377. 10.1158/2159-8290.CD-13-0183.
Article
CAS
PubMed
Google Scholar
Gunther S, Kuhn M, Dunkel M, Campillos M, Senger C, Petsalaki E, Ahmed J, Urdiales EG, Gewiess A, Jensen LJ, et al: SuperTarget and Matador: resources for exploring drug-target relationships. Nucleic acids research. 2008, 36 (Database): D919-922.
Article
PubMed Central
PubMed
Google Scholar
Roth BL, Lopez E, Patel S, Kroeze WK: The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?. Neuroscientist. 2000, 6 (4): 252-262. 10.1177/107385840000600408.
Article
CAS
Google Scholar
Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, et al: DGIdb: mining the druggable genome. Nature methods. 2013, 10 (12): 1209-1210. 10.1038/nmeth.2689.
Article
CAS
PubMed
Google Scholar
Kuhn M, Szklarczyk D, Pletscher-Frankild S, Blicher TH, von Mering C, Jensen LJ, Bork P: STITCH 4: integration of protein-chemical interactions with user data. Nucleic acids research. 2014, 42 (Database): D401-407.
Article
PubMed Central
CAS
PubMed
Google Scholar
Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, et al: DrugBank 4.0: shedding new light on drug metabolism. Nucleic acids research. 2014, 42 (Database): D1091-1097.
Article
PubMed Central
CAS
PubMed
Google Scholar
Liu T, Lin Y, Wen X, Jorissen RN, Gilson MK: BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic acids research. 2007, 35 (Database): D198-201. 10.1093/nar/gkl999.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, et al: ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic acids research. 2012, 40 (Database): D1100-1107.
Article
PubMed Central
CAS
PubMed
Google Scholar
Aguero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AW, Chen F, et al: Genomic-scale prioritization of drug targets: the TDR Targets database. Nature reviews Drug discovery. 2008, 7 (11): 900-907. 10.1038/nrd2684.
Article
PubMed Central
PubMed
Google Scholar
Davis AP, Wiegers TC, Roberts PM, King BL, Lay JM, Lennon-Hopkins K, Sciaky D, Johnson R, Keating H, Greene N, et al: A CTD-Pfizer collaboration: manual curation of 88,000 scientific articles text mined for drug-disease and drug-phenotype interactions. Database : the journal of biological databases and curation. 2013, 2013: bat080-
Article
Google Scholar
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic acids research. 2010, 38 (Database): D237-243. 10.1093/nar/gkp970.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang Y, Suzek T, Zhang J, Wang J, He S, Cheng T, Shoemaker BA, Gindulyte A, Bryant SH: PubChem BioAssay: 2014 update. Nucleic acids research. 2014, 42 (Database): D1075-1082.
Article
PubMed Central
CAS
PubMed
Google Scholar
von Eichborn J, Murgueitio MS, Dunkel M, Koerner S, Bourne PE, Preissner R: PROMISCUOUS: a database for network-based drug-repositioning. Nucleic acids research. 2011, 39 (Database): D1060-1066. 10.1093/nar/gkq1037.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nickel J, Gohlke BO, Erehman J, Banerjee P, Rong WW, Goede A, Dunkel M, Preissner R: SuperPred: update on drug classification and target prediction. Nucleic acids research. 2014
Google Scholar
Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, Zhang L, Song Y, Liu X, Zhang J, et al: Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic acids research. 2012, 40 (Database): D1128-1136.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic acids research. 2000, 28 (1): 27-30. 10.1093/nar/28.1.27.
Article
PubMed Central
CAS
PubMed
Google Scholar
Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clinical pharmacology and therapeutics. 2012, 92 (4): 414-417. 10.1038/clpt.2012.96.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sun J, Wu Y, Xu H, Zhao Z: DTome: a web-based tool for drug-target interactome construction. BMC bioinformatics. 2012, 13 (Suppl 9): S7-10.1186/1471-2105-13-S9-S7.
Article
PubMed Central
PubMed
Google Scholar
Gao Z, Li H, Zhang H, Liu X, Kang L, Luo X, Zhu W, Chen K, Wang X, Jiang H: PDTD: a web-accessible protein database for drug target identification. BMC bioinformatics. 2008, 9: 104-10.1186/1471-2105-9-104.
Article
PubMed Central
PubMed
Google Scholar
Mathias SL, Hines-Kay J, Yang JJ, Zahoransky-Kohalmi G, Bologa CG, Ursu O, Oprea TI: The CARLSBAD database: a confederated database of chemical bioactivities. Database : the journal of biological databases and curation. 2013, 2013: bat044-
Article
Google Scholar
Yildirim MA, Goh KI, Cusick ME, Barabasi AL, Vidal M: Drug-target network. Nature biotechnology. 2007, 25 (10): 1119-1126. 10.1038/nbt1338.
Article
CAS
PubMed
Google Scholar
Zhang XD: Optimal high-throughput screening : practical experimental design and data analysis for genome-scale RNAi research. 2011, Cambridge: Cambridge University Press
Chapter
Google Scholar
Degtyarenko K, de Matos P, Ennis M, Hastings J, Zbinden M, McNaught A, Alcantara R, Darsow M, Guedj M, Ashburner M: ChEBI: a database and ontology for chemical entities of biological interest. Nucleic acids research. 2008, 36 (Database): D344-350.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Bryant SH: PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic acids research. 2009, 37 (Web Server): W623-633. 10.1093/nar/gkp456.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maglott D, Ostell J, Pruitt KD, Tatusova T: Entrez Gene: gene-centered information at NCBI. Nucleic acids research. 2011, 39 (Database): D52-57. 10.1093/nar/gkq1237.
Article
PubMed Central
CAS
PubMed
Google Scholar
Activities at the Universal Protein Resource (UniProt). Nucleic acids research. 2014, 42 (11): 7486-
Mi H, Muruganujan A, Thomas PD: PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic acids research. 2013, 41 (Database): D377-386.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sun J, Zhao M, Fanous AH, Zhao Z: Characterization of schizophrenia adverse drug interactions through a network approach and drug classification. BioMed research international. 2013, 2013: 458989-
PubMed Central
PubMed
Google Scholar
Sun J, Jia P, Fanous AH, Webb BT, van den Oord EJ, Chen X, Bukszar J, Kendler KS, Zhao Z: A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case. Bioinformatics. 2009, 25 (19): 2595-2602. 10.1093/bioinformatics/btp428.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cowley MJ, Pinese M, Kassahn KS, Waddell N, Pearson JV, Grimmond SM, Biankin AV, Hautaniemi S, Wu J: PINA v2.0: mining interactome modules. Nucleic acids research. 2012, 40 (Database): D862-865.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sokal J, Messias E, Dickerson FB, Kreyenbuhl J, Brown CH, Goldberg RW, Dixon LB: Comorbidity of medical illnesses among adults with serious mental illness who are receiving community psychiatric services. The Journal of nervous and mental disease. 2004, 192 (6): 421-427. 10.1097/01.nmd.0000130135.78017.96.
Article
PubMed
Google Scholar
Goff DC, Cather C, Evins AE, Henderson DC, Freudenreich O, Copeland PM, Bierer M, Duckworth K, Sacks FM: Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists. The Journal of clinical psychiatry. 2005, 66 (2): 183-194. 10.4088/JCP.v66n0205. quiz 147, 273-184
Article
PubMed
Google Scholar
Taipei Medical University Hospital, National Health Research Institutes T: Treatment Strategy for Refractory Schizophrenia: Drug Interaction Between Clozapine and Fluvoxamine. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000- [cited 2014 Aug 27]. NLM Identifier: NCT01401491
Legare N, Gregoire CA, De Benedictis L, Dumais A: Increasing the clozapine: norclozapine ratio with co-administration of fluvoxamine to enhance efficacy and minimize side effects of clozapine therapy. Medical hypotheses. 2013, 80 (6): 689-691. 10.1016/j.mehy.2012.12.024.
Article
CAS
PubMed
Google Scholar
Wigard ME, van Gool AR, Schulte PF: [Addition of fluvoxamine to clozapine: theory and practice]. Tijdschrift voor psychiatrie. 2013, 55 (2): 113-121.
CAS
PubMed
Google Scholar
Niitsu T, Fujisaki M, Shiina A, Yoshida T, Hasegawa T, Kanahara N, Hashimoto T, Shiraishi T, Fukami G, Nakazato M, et al: A randomized, double-blind, placebo-controlled trial of fluvoxamine in patients with schizophrenia: a preliminary study. Journal of clinical psychopharmacology. 2012, 32 (5): 593-601. 10.1097/JCP.0b013e3182664cfc.
Article
CAS
PubMed
Google Scholar
Poyurovsky M, Fuchs C, Pashinian A, Levi A, Weizman R, Weizman A: Reducing antipsychotic-induced weight gain in schizophrenia: a double-blind placebo-controlled study of reboxetine-betahistine combination. Psychopharmacology. 2013, 226 (3): 615-622. 10.1007/s00213-012-2935-2.
Article
CAS
PubMed
Google Scholar
Biedermann F, Fleischhacker WW, Kemmler G, Ebenbichler CF, Lechleitner M, Hofer A: Sibutramine in the treatment of antipsychotic-induced weight gain: a pilot study in patients with schizophrenia. International clinical psychopharmacology. 2014, 29 (3): 181-184. 10.1097/YIC.0000000000000022.
Article
PubMed
Google Scholar
Zink M, Englisch S, Meyer-Lindenberg A: Polypharmacy in schizophrenia. Current opinion in psychiatry. 2010, 23 (2): 103-111. 10.1097/YCO.0b013e3283366427.
Article
PubMed
Google Scholar
Ghanemi A: Schizophrenia and Parkinson's disease: Selected therapeutic advances beyond the dopaminergic etiologies. Alexandria Journal of Medicine. 2013, 49 (4): 287-291. 10.1016/j.ajme.2013.03.005.
Article
Google Scholar
Runyon SP, Carroll FI: Dopamine transporter ligands: recent developments and therapeutic potential. Current topics in medicinal chemistry. 2006, 6 (17): 1825-1843. 10.2174/156802606778249775.
Article
CAS
PubMed
Google Scholar
Andreou C, Veith K, Bozikas VP, Lincoln TM, Moritz S: Effects of dopaminergic modulation on automatic semantic priming: a double-blind study. Journal of psychiatry & neuroscience : JPN. 2014, 39 (2): 110-117.
Google Scholar
Erzengin M, Bilen C, Ergun A, Gencer N: Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors. Archives of physiology and biochemistry. 2014, 120 (1): 29-33. 10.3109/13813455.2013.863359.
Article
CAS
PubMed
Google Scholar
Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR: A census of human cancer genes. Nature reviews Cancer. 2004, 4 (3): 177-183. 10.1038/nrc1299.
Article
PubMed Central
CAS
PubMed
Google Scholar