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Figure 4 | BMC Systems Biology

Figure 4

From: Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters

Figure 4

Network visualization of a subnetwork underlying the signature for module B. Network visualization of the subnetwork with highest relevance scores for linking intervention targets and module B for DLI (A) and T0901317 (B). The subnetwork was obtained by including edges with relevance score above a dynamically obtained cutoff, which is 0.024 for DLI and 0.021 for T0901317, and all edges that connect nodes within module B (pink edges). Nodes with a red border are part of the co-expression module B. Node size and edge weight are scaled by relevance scores as calculated by the kWalks algorithm. Nodes are colored by log2 ratio of intervention versus high-fat diet gene expression and their shape indicates level of significance of differential expression (p < 0.05 has a round shape, FDR adjusted p < 0.05 has an octagon shape).

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