Fig. 2
From: Uncovering distinct protein-network topologies in heterogeneous cell populations
Simulations of the EGF and NGF signaling network in PC12 cells. a The simulated protein network, as previously described [24]. The elements (proteins, interactions and processes) that are unique to either EGF or NGF are colored red and green, respectively. The components that we later consider as the measured components of that system (i.e. Raf, Mek and Erk) are colored grey. b A 3-dimensional scatter plot showing the normalized levels of active (i.e. phosphorylated) Raf (pRaf), Mek (ppMek) and Erk (ppErk) versus each other at 2 minutes after NGF (green) or EGF (red) stimulation with noise level of 0.7. c The same as b but for 9 minutes after stimulation. d Time profiles of pRaf, ppMek and ppErk levels as a function of time after NGF (green) or EGF (red) stimulations, without noise (solid line) or with 0.7 noise level (green and red shadows)