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Table 3 Packages and methods for methylation differential analysis

From: Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential

Package

Method

References

methyAnalysis

Wilcoxon rank sum test

[100]

methyAnalysis, CpGAssoc, RnBeads, and IMA

t-test

[100–102]

-

Kolmogorov-Smirnov test

[104]

CpGAssoc

permutation test

[101]

RnBeads, IMA and minfi

empirical Bayes

[102, 103, 105]

bumphunter and minfi

bump hunting

[105, 106]