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Table 2 The distribution of top 20 functional domains for human E3 ligases

From: A new scheme to discover functional associations and regulatory networks of E3 ubiquitin ligases

No. InterPro ID Domain terms Number of proteins % Total
1 IPR001680 WD40 repeat 287 57.5150 %
2 IPR006652 Kelch repeat type 1 68 13.6273 %
3 IPR000408 Regulator of chromosome condensation, RCC1 55 11.0220 %
4 IPR001841 Zinc finger, RING-type 54 10.8216 %
5 IPR000315 Zinc finger, B-box 48 9.6192 %
6 IPR003877 SPla/RYanodine receptor SPRY 38 7.6152 %
7 IPR013069 BTB/POZ 28 5.6112 %
8 IPR000569 HECT 28 5.6112 %
9 IPR001202 WW/Rsp5/WWP 28 5.6112 %
10 IPR020683 Ankyrin repeat-containing domain 27 5.4108 %
11 IPR001496 SOCS protein, C-terminal 25 5.0100 %
12 IPR002867 Zinc finger, C6HC-type 23 4.6092 %
13 IPR018957 Zinc finger, C3HC4 RING-type 22 4.4088 %
14 IPR001258 NHL repeat 21 4.2084 %
15 IPR011705 BTB/Kelch-associated 15 3.0060 %
16 IPR002110 Ankyrin repeat 14 2.8056 %
17 IPR000571 Zinc finger, CCCH-type 11 2.2044 %
18 IPR001876 Zinc finger, RanBP2-type 11 2.2044 %
19 IPR011016 Zinc finger, RING-CH-type 11 2.2044 %
20 IPR001452 Src homology-3 domain 10 2.0040 %