Fig. 10

Gene ontology enrichment of genes associated with gain or loss of correlation in ER+ samples compared to TN. Genes identified as members of gene pairs with a significant gain in correlation (q < 0.01) in the estrogen receptor-positive (ER+) samples compared to the triple negative (TN) breast cancer samples were used as inputs to gene ontology (GO) enrichment analysis in GOstats. GO terms with less than 50 or greater than 600 gene symbol members were filtered out included for the purposes of interpretability. Odds ratios for the GO enrichment of terms were compared between these two groups, and p-values were adjusted using the Benjamini-Hochberg method for each GO term category to yield false discovery rates (FDR). Up to 5 GO terms enriched in one of the groups compared to the other at FDR < 0.3 are shown. No terms from the “Molecular Function” GO term category portion passed this FDR threshold and are therefore not shown. This plot was made using the DGCA wrapper function to the plotrix R package