Fig. 16

Comparison of modules detected with DGCA/MEGENA to those detected with DiffCoEx and DICER. a: The number of modules significantly enriched (Fisher’s Exact Test; FDR < 0.3) that were detected by each of DGCA/MEGENA (red), DiffCoEx (green), and DICER (blue) in five different gene sets selected for their relevance to breast cancer. b: The proportion of modules detected by each of the three methods that are not significantly enriched in (i.e., do not overlap with) any of the modules detected by one (off-diagonals) or both (diagonals) of the other methods, by Fisher’s Exact Test, Benjamini-Hochberg adjusted p-value < 0.05. Columns labels denote the reference method compared; e.g., 62% of DGCA/MEGENA-detected modules do not significantly overlap with modules detected by either method, and 78% of DGCA/MEGENA-detected modules do not significantly overlap with any DICER-detected modules