Fig. 6

The three-node mutual repression model, with added positive auto-regulation on each node. a The model is studied in two dimensions using StabilityFinder, with clustering performed on the levels of X and Y. b Null clines and steady states of the three-node switch. c An example phase plot from the posterior of the three-node switch and d the phase plot of 100 particles from the final model. Each particle is represented by a different shade of blue. e The posterior distribution of the 6-steady state three-node system plotted on the prior ranges. Parameters for degradation, k _x , and the Hill coefficient, n _xy , are the most constrained. Parameter legend key: g _x production rate; k _x degradation rate; n _xy Hill coefficient; x _xy Hill threshold concentration; l _xy transcription rate fold change; n _xx autoregulation Hill coefficient; x _xx autoregulation Hill threshold concentration; l _xx autoregulation transcription rate fold change