Table 1 Fitness costs of antibiotic resistance on multiple substrates

Glucose

0.00

0.00

0.71

0.21

1.80

3

9.5

2

Glucose-6-phosphate

0.09

0.01

1.08

0.77

2.23

3

3

2

3.5

2

Glyceraldehyde 3-phosphate

0.00

0.00

0.00

0.00

0.00

Fructose 1,6-bisphosphate

0.00

0.01

1.14

0.23

0.25

3

1.5

6

10

Fumarate

0.00

0.06

1.55

0.21

0.27

3

1.5

12

13.5

Maleic acid

0 ^d

0.00

0.60

0 ^a

0 ^c

1

D-Malic acid

0.08

0.01

0.67

1.89

0 ^b

2.5

15.5

1.5

0

Succinate

0.00

0.00

1.00

0 ^a

0 ^b

2.5

Oxalic acid

0.00

0.00

0.00

0.00

0.00

Oxoadipic acid

0.04

0.00

0.62

0 ^e

0 ^c

0

0

Malonic acid

0.11

0.03

1.08

0.45

0.17

2.5

2.5

1.5

2

18

Pyruvate

0.41

0.00

0.58

0 ^e

0 ^b

4

2.5

Citric acid

0.00

0.00

0.00

0.00

0.00

Isocitric Acid

0.46

0.00

1.31

0.32

0.32

10

3.5

3.5

12.5

L-Lactic acid

0.29

0.00

0.99

1.05

0.16

3

4.5

4.5

18

Ketoglutaric acid

0.15

0.09

0.19

0.24

0.04

0

0

3.5

0

21

L-Arabinose

0.00

0.00

0.88

0.54

0.29

3.5

3.5

13.5

Manose 6-Phosphate

0.18

0.00

1.08

0.98

1.68

3

2.5

3.5

2.5

Ribose 5-phosphate

0.28

0.00

0.86

0.33

0.18

2.5

2.5

6

6

3-phosphoglyceric acid

0.29

0.26

0.28

0.40

0.18

2

2

0

6

6

L-Tryptophan

0.00

0.00

0.53

0.23

1.92

2

2

2

L-Alanine

0.21

0.00

0.96

0.28

0.36

2.5

2.5

6

3.5

L-Valine

0.28

0.00

0.74

0.33

0.14

2

2

6

6

L-Aspartate

0.27

0.20

0.19

0.41

0.18

2.5

2.5

0

6

10

L-Glutamine

0.00

0.00

0.83

1.15

0.26

2.5

3.5

13

L-Glutamate

0.52

0.16

1.28

1.12

0.23

3

3

3

3

12.5

Mannitol

0.24

0.00

1.00

0.98

0.20

3

2

3.5

8.5

D-Sorbitol

0.24

0.00

0.58

0.40

0.25

12.5

2.5

6

9.5

Glycerol

0.00

0.00

0.78

0.28

1.99

2.5

9.5

2.5

L-Ascorbic acid

0.00

0.18

0.81

0.23

0.27

3

3

6

12

Luria bertani

0.00

0.00

0.47

0.37

1.69

3

3

1.5

3

3