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Table 3 Significant biological functions predicted by IPA (A) and differentially expressed genes involved in SMC-specific functions (B)

From: Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells

A. Significant biological functions (42 genes in total)
Category P-value Number of involved genes
Cellular movement 1.34∙10−10 − 2.31∙10−3 25
 Migration of SMCs 9.87∙10−5 5
 Migration of VSMCs 2.35∙10−4 4
Cell−to−cell signaling and interaction 1.34∙10−10 − 2.45∙10−3 19
 Adhesion of SMCs 7.95∙10−4 2
Cellular growth and proliferation 4.21∙10−7 − 2.49∙10−3 27
 Proliferation of SMCs 4.21∙10−7 9
Skeletal and muscular system development and function 4.21∙10−7 − 2.24∙10−3 18
 Contraction of SMCs 2.17∙10−3 3
Cell cycle 5.27∙10−7 − 1.50∙10−3 15
B. Differentially expressed genes involved in SMC−specific functions
Category Involved genes
Migration of SMCs ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↑ F3, ↓ Rhoa
Migration of VSMCs ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↓ Rhoa
Adhesion of SMCs ↓ Cx3cl1, ↓ Rhoa
Proliferation of SMCs ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↑ F3,
↓ Nppb, ↓ Cx3cl1, ↓ Rhoa, ↓ Prrx1, ↓ Cav1
Contraction of SMCs ↑ Ptgs2, ↓ Rhoa, ↓ Cav1
  1. ↑ = upregulated, ↓ = downregulated, Egr1 = early growth response 1, Ptgs2 = prostaglandin−endoperoxide synthase 2 (COX−2), Serpine1 = serpin family E member 1 (plasminogen activator inhibitor−1 = PAI−1), F3 = coagulation factor III, tissue factor, Rhoa = ras homolog family member A, Cx3cl1 = chemokine (C−X3−C motif) ligand 1, Nppb = natriuretic peptide B, Prrx1 = paired related homeobox 1, Cav1 = caveolin 1