Table 3 Significant biological functions predicted by IPA (A) and differentially expressed genes involved in SMC-specific functions (B)
A. Significant biological functions (42 genes in total) | ||
Category | P-value | Number of involved genes |
Cellular movement | 1.34∙10−10 − 2.31∙10−3 | 25 |
Migration of SMCs | 9.87∙10−5 | 5 |
Migration of VSMCs | 2.35∙10−4 | 4 |
Cell−to−cell signaling and interaction | 1.34∙10−10 − 2.45∙10−3 | 19 |
Adhesion of SMCs | 7.95∙10−4 | 2 |
Cellular growth and proliferation | 4.21∙10−7 − 2.49∙10−3 | 27 |
Proliferation of SMCs | 4.21∙10−7 | 9 |
Skeletal and muscular system development and function | 4.21∙10−7 − 2.24∙10−3 | 18 |
Contraction of SMCs | 2.17∙10−3 | 3 |
Cell cycle | 5.27∙10−7 − 1.50∙10−3 | 15 |
B. Differentially expressed genes involved in SMC−specific functions | ||
Category | Involved genes | |
Migration of SMCs | ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↑ F3, ↓ Rhoa | |
Migration of VSMCs | ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↓ Rhoa | |
Adhesion of SMCs | ↓ Cx3cl1, ↓ Rhoa | |
Proliferation of SMCs | ↑ Egr1, ↑ Ptgs2, ↑ Serpine1, ↑ F3, ↓ Nppb, ↓ Cx3cl1, ↓ Rhoa, ↓ Prrx1, ↓ Cav1 | |
Contraction of SMCs | ↑ Ptgs2, ↓ Rhoa, ↓ Cav1 | |