Fig. 6
From: Integrating transcriptional activity in genome-scale models of metabolism
Showed in a are the results of calibrating the softplus parameter for the different diauxic phases, two before and two after glucose depletion, the relative errors (red) and objective function (blue) values are plotted. In b the log(Biomass) results of a dynamic FBA simulation of growth using a normal FBA model(red) a CoRegFlux model(blue) and comparison with the smoothed growth curve from the experimental data set(green). Table c provides a comparison in fold-change between the fluxes obtained by an FBA model and a CoRegFlux model before glucose depletion (t=-0.6 h), positive fold change implies that the CoRegFlux models finds solutions with more mass going through the reaction than FBA, negative values imply reduced flux through the CoRegFlux model compared to FBA. Table d is analogous to the previous table but with post-glucose depletion conditions (t=0.8 h)