The U-BIOPRED study group consists of Ian M. Adcock (Imperial College, London, UK), Nora Adriaens (University of Amsterdam, The Netherlands), Hassan Ahmed (EISBM, Lyon, France), Antonios Aliprantis (Merck Research, Boston, USA), Kjell Alving (Uppsala University, Sweden), Charles Auffray (EISBM, Lyon, France), Philipp Badorrek (Fraunhofer ITEM, Hannover, Germany), Cornelia Faulenbach (Fraunhofer ITEM, Hannover, Germany), Per Bakke (University of Bergen, Norway), David Balgoma (Karolinska Institutet, Stockholm, Sweden), Aruna T. Bansal (Acclarogen Ltd. Cambridge, UK), Clair Barber (University of Southampton, UK), Frédéric Baribaud (Janssen R & D, Springhouse, USA), An Bautmans (MSD Brussels, Belgium), Annelie F. Behndig (Umeå University, Sweden), Elisabeth Bel (University of Amsterdam, The Netherlands), Jorge Beleta (Almirall S.A., Barcelona, Spain), Ann Berglind (Karolinska Institutet, Stockholm, Sweden), Alix Berton (AstraZeneca, Mölndal, Sweden), Jeanette Bigler (Amgen Inc., Seattle, USA), Hans Bisgaard, University of Copenhagen, Denmark), Grazyna Bochenek, Jagiellonian University, Krakow, Poland), Michael J. Boedigheimer (Amgen Inc., Seattle, USA), Klaus Bønnelykke (University of Copenhagen, Denmark), Joost Brandsma, (University of Southampton, UK), Armin Braun (Fraunhofer ITEM, Hannover, Germany), Paul Brinkman (University of Amsterdam, The Netherlands), Dominic Burg (University of Southampton, UK), Davide Campagna (University of Catania, Italy), Leon Carayannopoulos, (MSD, USA), Massimo Caruso (University of Catania, Italy), Pedro Carvalho da Purificacão Rocha João Pedro (Royal Brompton and Harefield NHS Fondation Trust, UK), Amphun Chaiboonchoe (EISBM, Lyon, France), Romanas Chaleckis (Karolinska Institutet, Stockholm, Sweden), Pascal Chanez (University of Aix Marseille, France), Kiang Fan Chung, Imperial College London, UK), Courtney Coleman (Asthma UK, London, UK), Chris Compton (GSK, UK), Julie Corfield (Arateva R & D, Nottingham, UK), Arnaldo D’Amico (University of Rome ‘Tor Vergata’, Rome, Italy), Barbro Dahlén (Karolinska Institutet, Stockholm, Sweden), Sven-Erik Dahlén (Karolinska Institutet, Stockhlom, Sweden), Jorge De Alba (Almirall S.A., Barcelona, Spain), Pim de Boer (Londfonds, Amersfoort, The Netherlands), Inge De Lepeleire (MSD, Brussels, Belgium), Bertrand De Meulder (EISBM, Lyon, France), Tamara Dekker (University of Amsterdam, The Netherlands), Ingrid Delin (Karolinska Institutet, Stockholm, Sweden), Patrick Dennison (University of Southampton, UK), Annemiek Dijkhuis (University of Amsterdam, The Netherlands), Ratko Djukanovic (University of Southampton, UK), Aleksandra Draper (BioSci Consulting, Maasmechelen, Belgium), Jessica Edwards (Asthma UK, London, UK), Rosalia Emma (University of Catania, Italy), Magnus Ericsson (Karolinska University Hospital, Stockholm, Sweden), Veit Erpenbeck (Novartis Institutes for Biomedical Research, Basel, Switzerland), Damijan Erzen (Boehringer Ingelheim Pharma GmbH & Co. KKKG; Biberach, Germany), Klaus Fichtner (Boehringer Ingelheim Pharma GmbH & Co. KKKG; Biberach, Germany), Neil Fitch (BioSci Consulting, Maasmechelen, Belgium), Louise J. Fleming (Imperial College London, UK), Breda Flood (Asthma UK, London, UK), Stephen J. Fowler (Manchester Academic Health Sciences Center, Manchester, UK), Urs Frey (University Children’s Hospital, Basel, Switzerland), Martina Gahlemann (Boehringer Ingelheim GmbH, Switzerland), Gabriella Galffy (Semmelweis University, Budapest, Hungary), Hactor Gallart (Karolinska Institutet, Stockholm, Sweden), Trevor Garret (BioSci Consulting, Maasmechelen, Belgium), Thomas Geiser (University Hospital Bern, Switzerland), Julaiha Gent (Royal Brompton and Harefield NHS Fondation Trust, London, UK), Maria Gerhardsson de Verdier (AstraZeneca Molndal, Sweden), David Gibeon (Imperial College, London, UK), Cristina Gomez (Karolinska Institutet, Stockholm, Sweden), Kerry Gove (NIHR Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, Southampton, UK), Neil Gozzard (UCB, UK), Yi-ke Guo (Imperial College, London, UK), Simone Hashimoto (University of Amsterdam, The Netherlands), John Haughney (International Primary Care Respiratory Group, Aberdeen, Scotland), Gunilla Hedlin (Karolinska Institutet, Stockholm, Sweden), Pieter-Paul Hekking (University of Amsterdam, The Netherlands), Elisabeth Henriksson (Karolinska Institutet, Stockholm, Sweden), Lorraine Hewitt (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Tim Higgenbottam (Allergy Therapeutics, West Sussex, UK), Uruj Hoda (Imperial College, London, UK), Jans Hohlfeld (Fraunhofer ITEM, Hannover, Germany), Cecile Holweg (Genentech, San Francisco, USA), Ildiko Horvath (Semmelweis University, Budapest, Hungary), Peter Howarth (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Richard Hu (Amgen Inc., Seattle, USA), Sile Hu (Imperial College London, UK), Xugang Hu (Amgen Inc., Seattle, USA), Val Hudson (Asthma UK, London, UK), Anna J. James (Karolinska Institutet, Stockholm, Sweden), Juliette Kamphuis (Longfonds, Amersfoort, The Netherlands), Erika J. Kennington (Asthma UK, London, UK), Dyson Kerry (CromSource, Stirling, UK), Matthias Klüglich (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Hugo Knobel (Philips Research Laboratories, Eindhoven, The Netherlands), Richard Knowles (Arachos Pharma, UK), Alan Know (University of Nottingham, UK), Johan Kolmert (Karolinska Institutet, Stockholm, Sweden), Jon Konradsen (Karolinska Institutet, Stockholm, Sweden), Maxim Kots (Chiesi Pharmaceutical, Parma, Italy), Linn Krueger (University Children’s Hospital, Bern, Switzerland), Norbert Krug (Fraunhofer ITEM, Hannover, Germany), Scott Kuo (Imperial College, London, UK), Maciej Kupczyk (Karolinska Institutet, Stockholm, Sweden), Bart Lambrecht (University of Gent, Belgium), Ann-Sofie Lantz (Karolinska Institutet, Stockholm, Sweden), Lars Lazarinis (Karolinska Institutet, Stockholm, Sweden), Diane Lefaudeux (EISBM, Lyon, France), Saeeda Lone-Latif (University of Amsterdam, The Netherlands), Matthew J. Loza (Janssen R & D, Springhouse, USA), Rene Lutter (University of Amsterdam, The Netherlands), Lisa Marouzet (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Jane Martin (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Sarah Masefield (European Lung Fondation, Shefield, UK), Caroline Mathon (Karolinska Institutet, Stockholm, Sweden), John G. Matthews (Genentech, San Francisco, USA), Alexander Mazein (EISBM, Lyon, France), Sally Meah (Imperial College, London, UK), Andrea Meiser (Imperial College, London, UK), Andrew Manzies-Gow (Royal Brompton and Harefield NHS Fondation Trust, London, UK), Leanne Metcalf (Asthma UK, London, UK), Roelinde Middelveld (Karolinska Institutet, Stockholm, Sweden), Maria Mikus (Science for Life Laboratory, Stockholm, Sweden), Montse Miralpeix (Almirall, Barcelona, Spain), Philip Monk (Synairgen Research Ltd., Southampton, UK), Paolo Montuschi (Università Cattolica del Sacro Cuore, Rome, Italy), Nadia Mores (Università Cattolica del Sacro Cuore, Rome, Italy), Clare S. Murray (University of Manchester, UK), Jacek Musial (Jagiellonian University Medical College, Krakow, Poland), David Myles (GSK, UK), Shama Naz (Karolinska Institutet, Stockholm, Sweden), Katja Nething (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Ben Nicholas (University of Southampton, UK), Ulf Nihlen (AstraZeneca, Molndal, Sweden), Peter Nilsson (Science for Life Laboratory, Stockholm, Sweden), Björn Nordlund (Karolinska Institutet, Stockholm, Sweden), Jörgen Östling (AstraZeneca, Molndal, Sweden), Antonio Pacino (Lega Italiano Anti Fumo, Catania, Italy), Laurie Pahus (Aix-Marseille University, Marseille, France), Susanna Palkonen (European Federation of Allergy and Airways Diseases Patient’s Associations, Brussels, Belgium), Ioannis Pandis (Imperial College London, UK), Stelios Pavlidis (Imperial College London, UK), Giorgio Pennazza (University of Rome ‘Tor Vergata’, Rome, Italy), Anne Petrén (Karolinska Institutet, Stockholm, Sweden), Sandy Pink (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Anthony Postle (University of Southampton, UK), Pippa Powel (European Lung Fondation, Sheffield, UK), Malayka Rahman-Amin (Asthma UK, London, UK), Navin Rao (Janssen R & D, La Jolla, USA), Lara Ravanetti (University of Amsterdam, The Netherlands), Emma Ray (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Stacey Reinke (Karolinska Institutet, Stockholm, Sweden), Leanne Reynolds (Asthma UK, London, UK), Kathrin Riemann (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), John Riley (GSK, UK), Martine Robberechts (MSD, Brussels, Belgium), Amanda Roberts (Asthma UK, London, UK), Graham Roberts (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Christos Rossios (Imperial College London, UK), Anthony Rowe (Janssen R & D, UK), Kirsty Russel (Imperial College London, UK), Michael Rutgers (Longfonds, Amersfoort, The Netherlands), Thomas Sandström (Umeå University, Sweden), Giuseppe Santini (Università Cattolica del Sacro Cuore, Italy), Marco Santoninco (University of Rome ‘Tor Vergata’, Rome, Italy), Corinna Schoelch (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), James P.R. Schofield (University of Southampton, UK), Wolfgang Seibold (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Dominick E. Shaw (University of Nottingham, UK), Ralf Sigmund (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Florian Singer (University Children’s Hospital, Zurich, Switzerland), Marcus Sjödin (Karolinska Institutet, Stockholm, Sweden), Paul J. Skipp (University of Southampton, UK), Barbara Smids (University of Amsterdam, The Netherlands), Caroline Smith (NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK), Jessica Smith (Asthma UK, London, UK), Katherine M. Smith (University of Nottingham, UK), Päivi Söderman, Karolinska Institutet, Stockholm, Sweden), Adesimbo Sogbesan (Royal Brompton and Harefield NHS Fondation Trust, London, UK), Ana R. Sousa (GSK, UK), Doroteya Staykova (University of Southampton, UK), Peter J. Sterk (University of Amsterdam, The Netherlands), Karin Strandberg (Karolinska Institutet, Stockholm, Sweden), Kai Sun (Imperial College, London, UK), David Supple (Asthma UK, London, UK), Marton Szentkereszty (Semmelweis University, Budapest, Hungary), Lilla Tamasi (Semmelweis University, Budapest, Hungary), Kamran Tariq (University of Southampton, UK), John-Olof Thörngren (Karolinska University Hospital, Stockholm, Sweden), Bob Thornton (MSD, USA), Jonathan Thorsen (University of Copenhagen, Denmark), Salvatore Valente (Università Cattolica del Sacro Cuore, Rome, Italy), Wim van Aalderen (University of Amsterdam, The Netherlands), Marianne van de Pol (University of Amsterdam, The Netherlands), Kees van Drunen (University of Amsterdam, The Netherlands), Marleen van Drunen (University of Amsterdam, The Netherlands), Jenny Versnel (Asthma UK, London, UK), Jorgen Vestbo (Manchester Academic Health Sciences Centre, Manchester, UK), Anton Vink (Philips Research Laboratories, Eindhoven, The Netherlands), Nadja Vising (University of Copenhagen, Denmark), Christophe von Garnier (University Hospital, Bern, Switzerland), Ariane Wagener (University of Amsterdam, The Netherlands), Scott Wagers (BioSci Consulting, Maasmechelen, Belgium), Frans Wald (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Samantha Walker (Asthma UK, London, UK), Jonathan Ward (University of Southampton, UK), Zsoka Weiszhart (Semmelweis University, Budapest Hungary), Kristiane Wetzel (Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany), Craig E. Wheelock (Karolinska Institutet, Stockholm, Sweden), Coen Wiegman (Imperial College London, UK), Siân Williams (International Primary Care Respiratory Group, Aberdeen, Scotland), Susan J. Wilson (University of Southampton, UK), Ashley Woodcock (Manchester Academic Health Science Centre, Manchester, UK), Xian Yang (Imperial College London, UK), Elizabeth Yeyasingham (GSK, UK), Wen Yu (Amgen Inc., Seattle, USA), Wilhelm Zetterquist (Karolinska Institutet, Stockholm, Sweden), Koos Zwinderman (University of Amsterdam, The Netherlands). The eTRIKS consortium members are: Alireza Tamaddoni Nezhad (Imperial College London, UK), Adriano Barbosa da Silva (University of Luxemburg, Luxemburg), Alexander Mazein (EISBM, Lyon, France), Andreas Tielmann (Merck), Angela Gaudette (Pfizer), Anna Silberberg (Pfizer), Antigoni (Anna) Elefsinioti (Bayer), Axel Oehmichen (Imperial College London, UK), Maria Biryukov (University of Luxemburg, Luxemburg), Bertrand De Meulder (EISBM, Lyon, France), Jen Birgitte (Lundbeck), Bron Kisler (CDISC), Anna Maria Carusi, Charles Auffray (EISBM, Lyon, France), Diana O’Malley (Imperial College London, UK), David Henderson (Bayer), Dorina Bratfalean (CDISC), Diane Lefaudeux (EISBM, Lyon, France), Denny Verbeeck (Janssen), Ejner Knud Moltzen (Lundbeck), Eva Lindgren (Astra Zeneca), Florian Guitton (Imperial College London, UK), Fabien Richard (EISBM, Lyon, France), Francisco Bonachela Capdevila (Janssen), Ghita Rahal (CNRS, Lyon, France), Heike Dagmar Schuermann (Sanofi), Ibrahim Emam (Imperial College London, UK), Irina Balaur (EISBM, Lyon, France), Ingrid Sofie Harbo (Lundbeck), Jay Bergeron (Pfizer), Kai Sun (Imperial College London, UK), Laurence Mazuranok (Sanofi), Laurence Painell’s (IDBS), Manfred Hendlich (Sanofi), Gino Marchetti (CNRS, Lyon, France), Derek Marren (Lilly), Jaroslav Martasek (Lilly), Martin Romacker (Roche), Michael Braxenthaler (Roche), Maria Manuela Nogueira (EISBM, Lyon, France), Mansoor Saqi (EISBM, Lyon, France), Neil Fitch (BioSci Consulting), Nesrine Taibi (EISBM, Lyon, France), Odile Brasier (EISBM, Lyon, France), Paul Agapow (Imperial College London, UK), Peter Rice (Imperial College London, UK), Paul Houston (CDISC), Philippe Rocca-Serra (University of Oxford, UK), Reinhard Schneider (University of Luxemburg, Luxemburg), James Rimell (Lilly), Stelios Pavlidis (Imperial College London, UK), Susanna-Assunta Sansone (University of Oxford, UK), Sally Miles (Imperial College London, UK), Samiul Hasan (GSK), Sascha Herzinger (University of Luxemburg, Luxemburg), Scott Wagers (BioSci Consulting), Sikander Hayat (Bayer), Tomas Dalentoft (Astra Zeneca), Vahid Elyasigomari (Imperial College London, UK), Venkata Satagopam (University of Luxemburg, Luxemburg), Wei Gu (University of Luxemburg, Luxemburg), Xian Yang (Imperial College London, UK), Yi-Ke Guo (Imperial College London, UK).
Funding
This work was supported through the Innovative Medicines Initiative U-BIOPRED and eTRIKS projects (IMI n°115010 and IMI n°115446 respectively).
Availability of data and materials
The datasets analysed in this study are available in the NIH National Cancer Institute repository (https://portal.gdc.cancer.gov/) [117].