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Table 1 Some examples of SA bio-production systems using natural producers or metabolic engineered organisms

From: Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z

Organism Genetic modifications Culture conditions Carbon sources (CS) SA Yield
B. succiniciproducens   Anaerobic, continuous Glycerol 1.02 [21]
M. succiniproducens   Anaerobic, batch Glucose 0.59 [71]
M. succiniproducens – Deletion of ldhA, pflB, pta, and ackA genes Anaerobic, fed-batch Glucose 0.76 [30]
A. succinogenes   Anaerobic, continuous Xylose 0.80 [63]
A. succinogenes   Anaerobic, batch Glucose 0.74 [72]
A. succinogenes   Anaerobic, repeated fed-batch Glucose 0.88 [31]
E. coli – Deletion of pflB, ldhA, ppc genes
– Heterologous expression of pckA from B. subtilis
Anaerobic, batch Corn stalk hydrolysate 1.02 [43]
E. coli – Deletion of iclR, icd, sdhAB, ackA-pta, poxB
– Heterologous expression of pepc gene from Sorghum vulgare
Aerobic, batch Glucose 0.72 [73]
S. cerevisiae – Deletion of sdh3, ser3, ser33
– Overexpression of ICL1
Aerobic, batch Glucose 0.05 [37]
S. cerevisiae – Deletion of pdc1, pdc5, pdc6, fum1, gpd1
– Overexpression of pyc2, mdh3, fumC and frds1
Aerobic, batch Glucose 0.14 [19]
  1. Mass yields are given in g.g− 1 of carbon source (CS)