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Fig. 6 | BMC Systems Biology

Fig. 6

From: Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

Fig. 6

Fitting the stochastic model to wild type and previously unknown signaling mutants. a. examples of mutants that the model can explain. Red lines and blue lines respectively represent the K-L divergence as the remodeling parameter and activity parameter are decreased. The shaded areas show +/− 3 times the standard errors. The dashed line is the mean of wild type divergence from the wild type simulation. b. Examples of mutants that the model cannot explain. The red and blue lines do not come close to the dashed line. The right panel shows comparisons of experimental replicates (red traces) to predictions of the model (blue traces) when the value of the activity parameter is decreased chosen to maximize the fit (minimize KL divergence)

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