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Volume 10 Supplement 1

Selected articles from the Fourteenth Asia Pacific Bioinformatics Conference (APBC 2016): Systems Biology


Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. Articles have undergone the journal's standard peer review process. The Supplement Editors declare that they have no competing interests.

San Francisco, CA, USA11 - 13 January 2016

Edited by Jijun Tang, Lu Tian and Yi-Ping Phoebe Chen.

Related articles have been published in supplements to BMC Bioinformatics and BMC Genomics.

  1. MicroRNAs (miRNAs) have emerged as master regulators of angiogenesis and other cancer-related events. Discovering new angiogenesis-regulating microRNAs (angiomiRs) will eventually help in developing new therap...

    Authors: Hsin-Chuan Chang, Tsung-Han Hsieh, Yi-Wei Lee, Cheng-Fong Tsai, Ya-Ni Tsai, Cheng-Chung Cheng and Hsei-Wei Wang
    Citation: BMC Systems Biology 2016 10(Suppl 1):S1
  2. Developing novel uses of approved drugs, called drug repositioning, can reduce costs and times in traditional drug development. Network-based approaches have presented promising results in this field. However,...

    Authors: Hasun Yu, Sungji Choo, Junseok Park, Jinmyung Jung, Yeeok Kang and Doheon Lee
    Citation: BMC Systems Biology 2016 10(Suppl 1):S2
  3. Protein ubiquitination catalyzed by E3 ubiquitin ligases play important modulatory roles in various biological processes. With the emergence of high-throughput mass spectrometry technology, the proteomics rese...

    Authors: Kai-Yao Huang, Julia Tzu-Ya Weng, Tzong-Yi Lee and Shun-Long Weng
    Citation: BMC Systems Biology 2016 10(Suppl 1):S3
  4. Expression quantitative trait locus (eQTL) analysis has been widely used to understand how genetic variations affect gene expressions in the biological systems. Traditional eQTL is investigated in a pair-wise ...

    Authors: Huili Yuan, Zhenye Li, Nelson L.S. Tang and Minghua Deng
    Citation: BMC Systems Biology 2016 10(Suppl 1):S8
  5. The conjugation of ubiquitin to a substrate protein (protein ubiquitylation), which involves a sequential process – E1 activation, E2 conjugation and E3 ligation, is crucial to the regulation of protein functi...

    Authors: Chien-Hsun Huang, Min-Gang Su, Hui-Ju Kao, Jhih-Hua Jhong, Shun-Long Weng and Tzong-Yi Lee
    Citation: BMC Systems Biology 2016 10(Suppl 1):S6
  6. Protein domains can be viewed as portable units of biological function that defines the functional properties of proteins. Therefore, if a protein is associated with a disease, protein domains might also be as...

    Authors: Wangshu Zhang, Marcelo P. Coba and Fengzhu Sun
    Citation: BMC Systems Biology 2016 10(Suppl 1):S4
  7. CRISPR has been becoming a hot topic as a powerful technique for genome editing for human and other higher organisms. The original CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats coupled ...

    Authors: Tatiana C. Mangericao, Zhanhao Peng and Xuegong Zhang
    Citation: BMC Systems Biology 2016 10(Suppl 1):S5
  8. Cellular responses to extracellular perturbations require signaling pathways to capture and transmit the signals. However, the underlying molecular mechanisms of signal transduction are not yet fully understoo...

    Authors: Fan Zhang, Haoting Chen, Li Na Zhao, Hui Liu, Teresa M. Przytycka and Jie Zheng
    Citation: BMC Systems Biology 2016 10(Suppl 1):S7
  9. Schizophrenia is a severe psychiatric disorder which influences around 1 % of the worldwide population. Differences between male and female patients with schizophrenia have been noted. There is an earlier age ...

    Authors: Wenyi Qin, Cong Liu, Monsheel Sodhi and Hui Lu
    Citation: BMC Systems Biology 2016 10(Suppl 1):S9
  10. Complex diseases may have multiple pathways leading to disease. E.g. coronary artery disease evolves from arterial damage to their epithelial layers, but has multiple causal pathways. More challenging, those p...

    Authors: Daniel E. Platt, Saugata Basu, Pierre A. Zalloua and Laxmi Parida
    Citation: BMC Systems Biology 2016 10(Suppl 1):S10