Volume 12 Supplement 4

Selected papers from the 11th International Conference on Systems Biology (ISB 2017)

Research

Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editors declare that they have no competing interests.

Shenzhen, China18-21 August 2017

Conference website

Edited by Luonan Chen and Yong Wang.

Integrating data- and model-driven strategies in systems biology

A report of the 11th International Conference on Systems Biology (ISB2017), 18–21 August, Shenzhen, China.

Authors: Yong Wang, Xiang-Sun Zhang and Luonan Chen

Citation: BMC Systems Biology 2018 12(Suppl 4):38

Content type: Introduction

Published on: 24 April 2018
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Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. In order to explore the molecular mechanisms of wild and mutated samples from DBA patients were exposed to bioi...

Authors: Abbas Khan, Arif Ali, Muhammad Junaid, Chang Liu, Aman Chandra Kaushik, William C. S. Cho and Dong-Qing Wei

Citation: BMC Systems Biology 2018 12(Suppl 4):39

Content type: Research

Published on: 24 April 2018
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Differential networking meta-analysis of gastric cancer across Asian and American racial groups

Gastric Carcinoma is one of the most lethal cancer around the world, and is also the most common cancers in Eastern Asia. A lot of differentially expressed genes have been detected as being associated with Gas...

Authors: Wentao Dai, Quanxue Li, Bing-Ya Liu, Yi-Xue Li and Yuan-Yuan Li

Citation: BMC Systems Biology 2018 12(Suppl 4):51

Content type: Research

Published on: 24 April 2018
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Detecting complexes from edge-weighted PPI networks via genes expression analysis

Identifying complexes from PPI networks has become a key problem to elucidate protein functions and identify signal and biological processes in a cell. Proteins binding as complexes are important roles of life...

Authors: Zehua Zhang, Jian Song, Jijun Tang, Xinying Xu and Fei Guo

Citation: BMC Systems Biology 2018 12(Suppl 4):40

Content type: Research

Published on: 24 April 2018
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KF-finder: identification of key factors from host-microbial networks in cervical cancer

The human body is colonized by a vast number of microbes. Microbiota can benefit many normal life processes, but can also cause many diseases by interfering the regular metabolism and immune system. Recent stu...

Authors: Jialu Hu, Yiqun Gao, Yan Zheng and Xuequn Shang

Citation: BMC Systems Biology 2018 12(Suppl 4):54

Content type: Research

Published on: 24 April 2018
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PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

WD40 repeat proteins constitute one of the largest families in eukaryotes, and widely participate in various fundamental cellular processes by interacting with other molecules. Based on individual WD40 protein...

Authors: Xu-Dong Zou, Ke An, Yun-Dong Wu and Zhi-Qiang Ye

Citation: BMC Systems Biology 2018 12(Suppl 4):41

Content type: Research

Published on: 24 April 2018
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Modeling biological systems with uncertain kinetic data using fuzzy continuous Petri nets

Uncertainties exist in many biological systems, which can be classified as random uncertainties and fuzzy uncertainties. The former can usually be dealt with using stochastic methods, while the latter have to ...

Authors: Fei Liu, Siyuan Chen, Monika Heiner and Hengjie Song

Citation: BMC Systems Biology 2018 12(Suppl 4):42

Content type: Research

Published on: 24 April 2018
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Feedback regulation in a stem cell model with acute myeloid leukaemia

The haematopoietic lineages with leukaemia lineages are considered in this paper. In particular, we mainly consider that haematopoietic lineages are tightly controlled by negative feedback inhibition of end-pr...

Authors: Jianfeng Jiao, Min Luo and Ruiqi Wang

Citation: BMC Systems Biology 2018 12(Suppl 4):43

Content type: Research

Published on: 24 April 2018
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Multi-target drug repositioning by bipartite block-wise sparse multi-task learning

Finding potential drug targets is a crucial step in drug discovery and development. Recently, resources such as the Library of Integrated Network-Based Cellular Signatures (LINCS) L1000 database provide gene e...

Authors: Limin Li, Xiao He and Karsten Borgwardt

Citation: BMC Systems Biology 2018 12(Suppl 4):55

Content type: Research

Published on: 24 April 2018
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70ProPred: a predictor for discovering sigma70 promoters based on combining multiple features

Promoter is an important sequence regulation element, which is in charge of gene transcription initiation. In prokaryotes, σ⁷⁰ promoters regulate the transcription of most genes. The promoter recognition has been...

Authors: Wenying He, Cangzhi Jia, Yucong Duan and Quan Zou

Citation: BMC Systems Biology 2018 12(Suppl 4):44

Content type: Research

Published on: 24 April 2018
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Functional enrichment analysis based on long noncoding RNA associations

Differential gene expression analysis using RNA-seq data is a popular approach for discovering specific regulation mechanisms under certain environmental settings. Both gene ontology (GO) and KEGG pathway enri...

Authors: Kuo-Sheng Hung, Chung-Chi Hsiao, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou, Wen-Der Wang and Yet-Ran Chen

Citation: BMC Systems Biology 2018 12(Suppl 4):45

Content type: Research

Published on: 24 April 2018
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Hierarchical combinatorial deep learning architecture for pancreas segmentation of medical computed tomography cancer images

Efficient computational recognition and segmentation of target organ from medical images are foundational in diagnosis and treatment, especially about pancreas cancer. In practice, the diversity in appearance ...

Authors: Min Fu, Wenming Wu, Xiafei Hong, Qiuhua Liu, Jialin Jiang, Yaobin Ou, Yupei Zhao and Xinqi Gong

Citation: BMC Systems Biology 2018 12(Suppl 4):56

Content type: Research

Published on: 24 April 2018
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Improved flower pollination algorithm for identifying essential proteins

Essential proteins are necessary for the survival and development of cells. The identification of essential proteins can help to understand the minimal requirements for cellular life and it also plays an impor...

Authors: Xiujuan Lei, Ming Fang, Fang-Xiang Wu and Luonan Chen

Citation: BMC Systems Biology 2018 12(Suppl 4):46

Content type: Research

Published on: 24 April 2018
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Transcriptomic and metabolic flux analyses reveal shift of metabolic patterns during rice grain development

Rice (Oryza sativa) is one of the most important grain crops, which serves as food source for nearly half of the world population. The study of rice development process as well as related strategies for productio...

Authors: Fangzhou Shen, Xueting Wu, Luoxi Shi, Hang Zhang, Yangmin Chen, Xiaoquan Qi, Zhuo Wang and Xuan Li

Citation: BMC Systems Biology 2018 12(Suppl 4):47

Content type: Research

Published on: 24 April 2018
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Fixation probability of a beneficial mutation conferring decreased generation time in changing environments

One central building block of population genetics is the fixation probability. It is a probabilistic understanding of the eventual fate of new mutations. Moreover, the fixation probability of new beneficial mu...

Authors: Fangshu Cui and Bo Yuan

Citation: BMC Systems Biology 2018 12(Suppl 4):48

Content type: Research

Published on: 24 April 2018
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Selected papers from the 11th International Conference on Systems Biology (ISB 2017)

Research

Integrating data- and model-driven strategies in systems biology

Identification of novel drug targets for diamond-blackfan anemia based on RPS19 gene mutation using protein-protein interaction network

Differential networking meta-analysis of gastric cancer across Asian and American racial groups

Detecting complexes from edge-weighted PPI networks via genes expression analysis

KF-finder: identification of key factors from host-microbial networks in cervical cancer

PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions

Modeling biological systems with uncertain kinetic data using fuzzy continuous Petri nets

Feedback regulation in a stem cell model with acute myeloid leukaemia

Multi-target drug repositioning by bipartite block-wise sparse multi-task learning

70ProPred: a predictor for discovering sigma70 promoters based on combining multiple features

Functional enrichment analysis based on long noncoding RNA associations

Hierarchical combinatorial deep learning architecture for pancreas segmentation of medical computed tomography cancer images

Improved flower pollination algorithm for identifying essential proteins

Transcriptomic and metabolic flux analyses reveal shift of metabolic patterns during rice grain development

Fixation probability of a beneficial mutation conferring decreased generation time in changing environments

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