Volume 7 Supplement 2

Selected articles from the 6th International Conference on Computational Systems Biology (ISB2012)


Edited by Luonan Chen, Xiang-Sun Zhang and Yong Wang

Publication charges were partly funded by the Chinese Academy of Sciences. The source of funding used to cover the remainder of the open access charges is declared by the authors in each article. Articles have undergone the journal's standard peer-review process for supplements. The Supplement Editors declare that they have no competing interests.

The 6th International Conference on Computational Systems Biology (ISB2012). Go to conference site.

Xi'an, China

18-20 August 2012

  1. Research

    SAVI: a statistical algorithm for variant frequency identification

    Many problems in biomedical research can be posed as a comparison between related samples (healthy vs. disease, subtypes of the same disease, longitudinal data representing the progression of a disease, etc). ...

    Vladimir Trifonov, Laura Pasqualucci, Enrico Tiacci, Brunangelo Falini and Raul Rabadan

    BMC Systems Biology 2013 7(Suppl 2):S2

    Published on: 14 October 2013

  2. Research

    A computational method for predicting regulation of human microRNAs on the influenza virus genome

    While it has been suggested that host microRNAs (miRNAs) may downregulate viral gene expression as an antiviral defense mechanism, such a mechanism has not been explored in the influenza virus for human flu st...

    Hao Zhang, Zhi Li, Yanpu Li, Yuanning Liu, Junxin Liu, Xin Li, Tingjie Shen, Yunna Duan, Minggang Hu and Dong Xu

    BMC Systems Biology 2013 7(Suppl 2):S3

    Published on: 14 October 2013

  3. Research

    Corbi: a new R package for biological network alignment and querying

    In the last decade, plenty of biological networks are built from the large scale experimental data produced by the rapidly developing high-throughput techniques as well as literature and other sources. But the...

    Qiang Huang, Ling-Yun Wu and Xiang-Sun Zhang

    BMC Systems Biology 2013 7(Suppl 2):S6

    Published on: 14 October 2013

  4. Research

    cGRNB: a web server for building combinatorial gene regulatory networks through integrated engineering of seed-matching sequence information and gene expression datasets

    We are witnessing rapid progress in the development of methodologies for building the combinatorial gene regulatory networks involving both TFs (Transcription Factors) and miRNAs (microRNAs). There are a few t...

    Huayong Xu, Hui Yu, Kang Tu, Qianqian Shi, Chaochun Wei, Yuan-Yuan Li and Yi-Xue Li

    BMC Systems Biology 2013 7(Suppl 2):S7

    Published on: 14 October 2013

  5. Research

    ppiPre: predicting protein-protein interactions by combining heterogeneous features

    Protein-protein interactions (PPIs) are crucial in cellular processes. Since the current biological experimental techniques are time-consuming and expensive, and the results suffer from the problems of incompl...

    Yue Deng, Lin Gao and Bingbo Wang

    BMC Systems Biology 2013 7(Suppl 2):S8

    Published on: 14 October 2013

    The Erratum to this article has been published in BMC Systems Biology 2015 9:50

  6. Research

    HSA: A Heuristic Splice Alignment Tool

    RNA-Seq methodology is a revolutionary transcriptomics sequencing technology, which is the representative of Next generation Sequencing (NGS). With the high throughput sequencing of RNA-Seq, we can acquire muc...

    Jingde Bu, Xuebin Chi and Zhong Jin

    BMC Systems Biology 2013 7(Suppl 2):S10

    Published on: 17 December 2013

  7. Research

    A 3D multiscale model of cancer stem cell in tumor development

    Recent reports indicate that a subgroup of tumor cells named cancer stem cells (CSCs) or tumor initiating cells (TICs) are responsible for tumor initiation, growth and drug resistance. This subgroup of tumor c...

    Fuhai Li, Hua Tan, Jaykrishna Singh, Jian Yang, Xiaofeng Xia, Jiguang Bao, Jinwen Ma, Ming Zhan and Stephen TC Wong

    BMC Systems Biology 2013 7(Suppl 2):S12

    Published on: 17 December 2013