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Volume 7 Supplement 2

Selected articles from the 6th International Conference on Computational Systems Biology (ISB2012)


Edited by Luonan Chen, Xiang-Sun Zhang and Yong Wang

Publication charges were partly funded by the Chinese Academy of Sciences. The source of funding used to cover the remainder of the open access charges is declared by the authors in each article. Articles have undergone the journal's standard peer-review process for supplements. The Supplement Editors declare that they have no competing interests.

The 6th International Conference on Computational Systems Biology (ISB2012). Go to conference site.

Xi'an, China18-20 August 2012

  1. Many problems in biomedical research can be posed as a comparison between related samples (healthy vs. disease, subtypes of the same disease, longitudinal data representing the progression of a disease, etc). ...

    Authors: Vladimir Trifonov, Laura Pasqualucci, Enrico Tiacci, Brunangelo Falini and Raul Rabadan
    Citation: BMC Systems Biology 2013 7(Suppl 2):S2
  2. While it has been suggested that host microRNAs (miRNAs) may downregulate viral gene expression as an antiviral defense mechanism, such a mechanism has not been explored in the influenza virus for human flu st...

    Authors: Hao Zhang, Zhi Li, Yanpu Li, Yuanning Liu, Junxin Liu, Xin Li, Tingjie Shen, Yunna Duan, Minggang Hu and Dong Xu
    Citation: BMC Systems Biology 2013 7(Suppl 2):S3
  3. Understanding the molecular mechanisms underlying cancer is an important step for the effective diagnosis and treatment of cancer patients. With the huge volume of data from the large-scale cancer genomics pro...

    Authors: Junhua Zhang, Shihua Zhang, Yong Wang and Xiang-Sun Zhang
    Citation: BMC Systems Biology 2013 7(Suppl 2):S4
  4. We are witnessing rapid progress in the development of methodologies for building the combinatorial gene regulatory networks involving both TFs (Transcription Factors) and miRNAs (microRNAs). There are a few t...

    Authors: Huayong Xu, Hui Yu, Kang Tu, Qianqian Shi, Chaochun Wei, Yuan-Yuan Li and Yi-Xue Li
    Citation: BMC Systems Biology 2013 7(Suppl 2):S7
  5. Protein-protein interactions (PPIs) are crucial in cellular processes. Since the current biological experimental techniques are time-consuming and expensive, and the results suffer from the problems of incompl...

    Authors: Yue Deng, Lin Gao and Bingbo Wang
    Citation: BMC Systems Biology 2013 7(Suppl 2):S8

    The Erratum to this article has been published in BMC Systems Biology 2015 9:50

  6. With recent advances in microarray technology, including genomics, proteomics, and metabolomics, it brings a great challenge for integrating this "-omics" data to analysis complex disease. Glioma is an extreme...

    Authors: Yangfan Hu, Jinquan Li, Wenying Yan, Jiajia Chen, Yin Li, Guang Hu and Bairong Shen
    Citation: BMC Systems Biology 2013 7(Suppl 2):S9
  7. RNA-Seq methodology is a revolutionary transcriptomics sequencing technology, which is the representative of Next generation Sequencing (NGS). With the high throughput sequencing of RNA-Seq, we can acquire muc...

    Authors: Jingde Bu, Xuebin Chi and Zhong Jin
    Citation: BMC Systems Biology 2013 7(Suppl 2):S10
  8. In dynamic biological processes, genes, transcription factors(TF) and microRNAs(miRNAs) play vital regulation roles. Many researchers have focused on the transcription factors or miRNAs in transcriptional or p...

    Authors: Juan Liu, Xinghuo Ye and Fang-Xiang Wu
    Citation: BMC Systems Biology 2013 7(Suppl 2):S11
  9. Recent reports indicate that a subgroup of tumor cells named cancer stem cells (CSCs) or tumor initiating cells (TICs) are responsible for tumor initiation, growth and drug resistance. This subgroup of tumor c...

    Authors: Fuhai Li, Hua Tan, Jaykrishna Singh, Jian Yang, Xiaofeng Xia, Jiguang Bao, Jinwen Ma, Ming Zhan and Stephen TC Wong
    Citation: BMC Systems Biology 2013 7(Suppl 2):S12
  10. Metabolism is a vital cellular process, and its malfunction can be a major contributor to many human diseases. Metabolites can serve as a metabolic disease biomarker. An detection of such biomarkers plays a si...

    Authors: Limin Li, Hao Jiang, Yushan Qiu, Wai-Ki Ching and Vassilios S Vassiliadis
    Citation: BMC Systems Biology 2013 7(Suppl 2):S13
  11. Discovering transcription factor binding sites (TFBS) is one of primary challenges to decipher complex gene regulatory networks encrypted in a genome. A set of short DNA sequences identified by a transcription...

    Authors: Shaoqiang Zhang, Xiguo Zhou, Chuanbin Du and Zhengchang Su
    Citation: BMC Systems Biology 2013 7(Suppl 2):S14
  12. To uncover molecular functions and networks in biological cellular systems, it is important to dissect interactions between proteins and RNAs. Many studies have been performed to investigate and analyze intera...

    Authors: Morihiro Hayashida, Mayumi Kamada, Jiangning Song and Tatsuya Akutsu
    Citation: BMC Systems Biology 2013 7(Suppl 2):S15