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Volume 8 Supplement 2

Selected articles from the High-Throughput Omics and Data Integration Workshop


Edited by David Gomez-Cabrero, Ana Conesa, Jesper Tegner, Dieter Maier, Matthias Merkenschlager, Imad Abugessaisa, Andreas Gisel, Erik Bongcam-Rudloff, Esteban Ballestar and Andrew Teschendorff

Publication of this supplement has been partially funded by COST-BMBS, Action BM1006 "Next Generation Sequencing Data Analysis Network", SeqAhead. Information about the source of funding for the remaining publication charges can be found in the individual articles. Articles have undergone the journal's standard review process for supplements. The Supplement Editors declare that they have no competing interests.

High-Throughput Omics and Data Integration Workshop. Go to conference site.

Barcelona, Spain13-15 February 2013

  1. To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through lar...

    Authors: David Gomez-Cabrero, Imad Abugessaisa, Dieter Maier, Andrew Teschendorff, Matthias Merkenschlager, Andreas Gisel, Esteban Ballestar, Erik Bongcam-Rudloff, Ana Conesa and Jesper Tegnér
    Citation: BMC Systems Biology 2014 8(Suppl 2):I1
  2. The rise of systems biology is intertwined with that of genomics, yet their primordial relationship to one another is ill-defined. We discuss how the growth of genomics provided a critical boost to the popular...

    Authors: Ana Conesa and Ali Mortazavi
    Citation: BMC Systems Biology 2014 8(Suppl 2):S1
  3. High-throughput omics technologies have enabled the measurement of many genes or metabolites simultaneously. The resulting high dimensional experimental data poses significant challenges to transcriptomics and...

    Authors: Polina Reshetova, Age K Smilde, Antoine HC van Kampen and Johan A Westerhuis
    Citation: BMC Systems Biology 2014 8(Suppl 2):S2
  4. Most biochemical reactions in a cell are regulated by highly specialized proteins, which are the prime mediators of the cellular phenotype. Therefore the identification, quantitation and characterization of al...

    Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof
    Citation: BMC Systems Biology 2014 8(Suppl 2):S3
  5. High-throughput genotype (HTG) data has been used primarily in genome-wide association (GWA) studies; however, GWA results explain only a limited part of the complete genetic variation of traits. In systems ge...

    Authors: Lisette JA Kogelman and Haja N Kadarmideen
    Citation: BMC Systems Biology 2014 8(Suppl 2):S5
  6. Nowadays, combining the different sources of information to improve the biological knowledge available is a challenge in bioinformatics. One of the most powerful methods for integrating heterogeneous data type...

    Authors: Ferran Reverter, Esteban Vegas and Josep M Oller
    Citation: BMC Systems Biology 2014 8(Suppl 2):S6
  7. The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipl...

    Authors: Ignacio Ponzoni, María José Nueda, Sonia Tarazona, Stefan Götz, David Montaner, Julieta Sol Dussaut, Joaquín Dopazo and Ana Conesa
    Citation: BMC Systems Biology 2014 8(Suppl 2):S7
  8. An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us ...

    Authors: Jörg Menche, Amitabh Sharma, Michael H Cho, Ruth J Mayer, Stephen I Rennard, Bartolome Celli, Bruce E Miller, Nick Locantore, Ruth Tal-Singer, Soumitra Ghosh, Chris Larminie, Glyn Bradley, John H Riley, Alvar Agusti, Edwin K Silverman and Albert-László Barabási
    Citation: BMC Systems Biology 2014 8(Suppl 2):S8
  9. High-throughput sequencing assays are now routinely used to study different aspects of genome organization. As decreasing costs and widespread availability of sequencing enable more laboratories to use sequenc...

    Authors: Rafael Hernández-de-Diego, Noemi Boix-Chova, David Gómez-Cabrero, Jesper Tegner, Imad Abugessaisa and Ana Conesa
    Citation: BMC Systems Biology 2014 8(Suppl 2):S9