Volume 8 Supplement 2
Edited by David Gomez-Cabrero, Ana Conesa, Jesper Tegner, Dieter Maier, Matthias Merkenschlager, Imad Abugessaisa, Andreas Gisel, Erik Bongcam-Rudloff, Esteban Ballestar and Andrew Teschendorff
Publication of this supplement has been partially funded by COST-BMBS, Action BM1006 "Next Generation Sequencing Data Analysis Network", SeqAhead. Information about the source of funding for the remaining publication charges can be found in the individual articles. Articles have undergone the journal's standard review process for supplements. The Supplement Editors declare that they have no competing interests.
High-Throughput Omics and Data Integration Workshop. Go to conference site.
Barcelona, Spain13-15 February 2013
To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through lar...
The rise of systems biology is intertwined with that of genomics, yet their primordial relationship to one another is ill-defined. We discuss how the growth of genomics provided a critical boost to the popular...
High-throughput omics technologies have enabled the measurement of many genes or metabolites simultaneously. The resulting high dimensional experimental data poses significant challenges to transcriptomics and...
Most biochemical reactions in a cell are regulated by highly specialized proteins, which are the prime mediators of the cellular phenotype. Therefore the identification, quantitation and characterization of al...
Technological improvements have shifted the focus from data generation to data analysis. The availability of large amounts of data from transcriptomics, protemics and metabolomics experiments raise new questio...
High-throughput genotype (HTG) data has been used primarily in genome-wide association (GWA) studies; however, GWA results explain only a limited part of the complete genetic variation of traits. In systems ge...
Nowadays, combining the different sources of information to improve the biological knowledge available is a challenge in bioinformatics. One of the most powerful methods for integrating heterogeneous data type...
The development of high-throughput omics technologies enabled genome-wide measurements of the activity of cellular elements and provides the analytical resources for the progress of the Systems Biology discipl...
An important step toward understanding the biological mechanisms underlying a complex disease is a refined understanding of its clinical heterogeneity. Relating clinical and molecular differences may allow us ...
High-throughput sequencing assays are now routinely used to study different aspects of genome organization. As decreasing costs and widespread availability of sequencing enable more laboratories to use sequenc...