Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches
Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over ph...
BMC Systems Biology 2017 11:35
Published on: 11 March 2017