Compston A, Coles A: Multiple sclerosis. Lancet. 2008, 372 (9648): 1502-1517. 10.1016/S0140-6736(08)61620-7
Article
CAS
PubMed
Google Scholar
Vollmer T: The natural history of relapses in multiple sclerosis. J Neurol Sci. 2007, 256 (Suppl 1): S5-13.
Article
PubMed
Google Scholar
Stone LA, Frank JA, Albert PS, Bash C, Smith ME, Maloni H, McFarland HF: The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann Neurol. 1995, 37 (5): 611-619. 10.1002/ana.410370511
Article
CAS
PubMed
Google Scholar
Chiu AW, Richert N, Ehrmantraut M, Ohayon J, Gupta S, Bomboi G, Gaindh D, Cantor FK, Frank JA, McFarland HF, et al.: Heterogeneity in Response to Interferon Beta in Patients With Multiple Sclerosis. Arch Neurol. 2009, 66 (1): e1-5. 10.1002/ana.21759.
Article
Google Scholar
Boiko A, Vorobeychik G, Paty D, Devonshire V, Sadovnick D: Early onset multiple sclerosis: a longitudinal study. Neurology. 2002, 59 (7): 1006-1010.
Article
CAS
PubMed
Google Scholar
Steinman L: Multiple sclerosis: a two-stage disease. Nat Immunol. 2001, 2 (9): 762-764. 10.1038/ni0901-762
Article
CAS
PubMed
Google Scholar
Confavreux C, Vukusic S, Moreau T, Adeleine P: Relapses and progression of disability in multiple sclerosis. N Engl J Med. 2000, 343 (20): 1430-1438. 10.1056/NEJM200011163432001
Article
CAS
PubMed
Google Scholar
Buljevac D, Flach HZ, Hop WC, Hijdra D, Laman JD, Savelkoul HF, Der Meche FG, van Doorn PA, Hintzen RQ: Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain. 2002, 125 (Pt 5): 952-960.
Article
CAS
PubMed
Google Scholar
Buljevac D, Hop WC, Reedeker W, Janssens AC, van der Meche FG, van Doorn PA, Hintzen RQ: Self reported stressful life events and exacerbations in multiple sclerosis: prospective study. BMJ. 2003, 327 (7416): 646- 10.1136/bmj.327.7416.646
Article
PubMed Central
CAS
PubMed
Google Scholar
Martin R, McFarland HF, McFarlin DE: Immunological aspects of demyelinating diseases. AnnuRevImmunol. 1992, 10: 153-187.
CAS
Google Scholar
Hauser SL, Oksenberg JR: The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron. 2006, 52 (1): 61-76. 10.1016/j.neuron.2006.09.011
Article
CAS
PubMed
Google Scholar
Diaz-Villoslada P, Shih A, Shao L, Genain CP, Hauser SL: Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. JNeuroimmunol. 1999, 99 (1): 36-43. 10.1016/S0165-5728(99)00099-5.
Article
CAS
Google Scholar
Villoslada P, Abel K, Heald N, Goertsches R, Hauser SL, Genain CP: Frequency, heterogeneity and encephalitogenicity of T cells specific for myelin oligodendrocyte glycoprotein in naive outbred primates. Eur J Immunol. 2001, 31 (10): 2942-2950. 10.1002/1521-4141(2001010)31:10<2942::AID-IMMU2942>3.0.CO;2-M
Article
CAS
PubMed
Google Scholar
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995, 155 (3): 1151-1164.
CAS
PubMed
Google Scholar
Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 2001, 182: 18-32. 10.1034/j.1600-065X.2001.1820102.x
Article
CAS
PubMed
Google Scholar
Thornton AM, Shevach EM: CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998, 188 (2): 287-296. 10.1084/jem.188.2.287
Article
PubMed Central
CAS
PubMed
Google Scholar
Thornton AM, Shevach EM: Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol. 2000, 164 (1): 183-190.
Article
CAS
PubMed
Google Scholar
Shevach EM, McHugh RS, Piccirillo CA, Thornton AM: Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev. 2001, 182: 58-67. 10.1034/j.1600-065X.2001.1820104.x
Article
CAS
PubMed
Google Scholar
Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006, 212: 8-27. 10.1111/j.0105-2896.2006.00427.x
Article
CAS
PubMed
Google Scholar
Fontenot JD, Rudensky AY: A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol. 2005, 6 (4): 331-337. 10.1038/ni1179
Article
CAS
PubMed
Google Scholar
van der Vliet HJ, Nieuwenhuis EE: IPEX as a result of mutations in FOXP3. Clin Dev Immunol. 2007, 2007: 89017-
Article
PubMed Central
PubMed
Google Scholar
Ochs HD, Gambineri E, Torgerson TR: IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res. 2007, 38 (1-3): 112-121. 10.1007/s12026-007-0022-2
Article
CAS
PubMed
Google Scholar
Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA: Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. JExpMed. 2004, 199 (7): 971-979.
Article
CAS
Google Scholar
Martinez-Forero I, Garcia-Munoz R, Martinez-Pasamar S, Inoges S, Lopez-Diaz de Cerio A, Palacios R, Sepulcre J, Moreno B, Gonzalez Z, Fernandez-Diez B, et al.: IL-10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis. Eur J Immunol. 2008, 38 (2): 576-586. 10.1002/eji.200737271
Article
CAS
PubMed
Google Scholar
Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, et al.: Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest. 2002, 109 (1): 131-140.
Article
PubMed Central
CAS
PubMed
Google Scholar
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, et al.: Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA. 2003, 100 (14): 8372-8377. 10.1073/pnas.1533209100
Article
PubMed Central
CAS
PubMed
Google Scholar
Almeida AR, Zaragoza B, Freitas AA: Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells. J Immunol. 2006, 177 (1): 192-200.
Article
CAS
PubMed
Google Scholar
Lund JM, Hsing L, Pham TT, Rudensky AY: Coordination of early protective immunity to viral infection by regulatory T cells. Science. 2008, 320 (5880): 1220-1224. 10.1126/science.1155209
Article
PubMed Central
CAS
PubMed
Google Scholar
Carneiro J, Leon K, Caramalho I, van den Dool C, Gardner R, Oliveira V, Bergman ML, Sepulveda N, Paixao T, Faro J, et al.: When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4(+) T cells. Immunol Rev. 2007, 216: 48-68.
Article
PubMed
Google Scholar
Germain RN: The art of the probable: system control in the adaptive immune system. Science. 2001, 293 (5528): 240-245. 10.1126/science.1062946
Article
CAS
PubMed
Google Scholar
Kekalainen E, Tuovinen H, Joensuu J, Gylling M, Franssila R, Pontynen N, Talvensaari K, Perheentupa J, Miettinen A, Arstila TP: A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol. 2007, 178 (2): 1208-1215.
Article
PubMed
Google Scholar
Belkaid Y, Rouse BT: Natural regulatory T cells in infectious disease. Nat Immunol. 2005, 6 (4): 353-360.
Article
CAS
PubMed
Google Scholar
O'Connor W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA: A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009, 10 (6): 603-609. 10.1038/ni.1736
Article
PubMed Central
PubMed
Google Scholar
Mackey MC, Milton JG: Dynamical diseases. Ann N Y Acad Sci. 1987, 504: 16-32. 10.1111/j.1749-6632.1987.tb48723.x
Article
CAS
PubMed
Google Scholar
Villoslada P, Steinman L, Baranzini SE: Systems biology and its application to the understanding of neurological diseases. Ann Neurol. 2009, 65 (2): 124-139. 10.1002/ana.21634
Article
CAS
PubMed
Google Scholar
von Herrath MG, Sanda S, Herold K: Type 1 diabetes as a relapsing-remitting disease?. Nat Rev Immunol. 2007, 7: 988-994. 10.1038/nri2192
Article
CAS
PubMed
Google Scholar
Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG: Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature. 2005, 435 (7042): 590-597. 10.1038/nature03724
Article
CAS
PubMed
Google Scholar
Leon K, Faro J, Lage A, Carneiro J: Inverse correlation between the incidences of autoimmune disease and infection predicted by a model of T cell mediated tolerance. J Autoimmun. 2004, 22 (1): 31-42. 10.1016/j.jaut.2003.10.002
Article
CAS
PubMed
Google Scholar
Lafaille JJ, Nagashima K, Katsuki M, Tonegawa S: High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994, 78 (3): 399-408. 10.1016/0092-8674(94)90419-7
Article
CAS
PubMed
Google Scholar
Burroughs NJ, Miguel Paz Mendes de Oliveira B, Adrego Pinto A: Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. J Theor Biol. 2006, 241 (1): 134-141. 10.1016/j.jtbi.2005.11.010
Article
CAS
PubMed
Google Scholar
Wu Y, Zhu WQ: Stochastic analysis of a pulse-type prey-predator model. Phys Rev E Stat Nonlin Soft Matter Phys. 2008, 77 (4 Pt 1): 041911-
Article
CAS
PubMed
Google Scholar
Borghans JA, De Boer RJ, Sercarz E, Kumar V: T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model. J Immunol. 1998, 161 (3): 1087-1093.
CAS
PubMed
Google Scholar
Borghans JA, De Boer RJ: A minimal model for T-cell vaccination. Proc Biol Sci. 1995, 259 (1355): 173-178. 10.1098/rspb.1995.0025
Article
CAS
PubMed
Google Scholar
Kitano H: A robustness-based approach to systems-oriented drug design. Nat Rev Drug Discov. 2007, 6 (3): 202-210. 10.1038/nrd2195
Article
CAS
PubMed
Google Scholar
Palacios R, Goni J, Martinez-Forero I, Iranzo J, Sepulcre J, Melero I, Villoslada P: A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS ONE. 2007, 2 (11): e1222- 10.1371/journal.pone.0001222
Article
PubMed Central
PubMed
Google Scholar
Carlson JM, Doyle J: Complexity and robustness. Proc Natl Acad Sci USA. 2002, 99 (Suppl 1): 2538-2545.
Article
PubMed Central
PubMed
Google Scholar
Wucherpfennig KW: Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest. 2001, 108 (8): 1097-1104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL: The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet. 2008, 9 (7): 516-526. 10.1038/nrg2395
Article
CAS
PubMed
Google Scholar
Bagnato F, Jeffries N, Richert ND, Stone RD, Ohayon JM, McFarland HF, Frank JA: Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years. Brain. 2003, 126 (Pt 8): 1782-1789.
Article
PubMed
Google Scholar
Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ: CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol. 2007, 8 (12): 1353-1362. 10.1038/ni1536
Article
CAS
PubMed
Google Scholar
Lawrence CW, Ream RM, Braciale TJ: Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. J Immunol. 2005, 174 (9): 5332-5340.
Article
CAS
PubMed
Google Scholar
Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL: IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004, 16 (2): 249-256. 10.1093/intimm/dxh029
Article
CAS
PubMed
Google Scholar
Walker J, Rigley K: Gene expression profiling in human peripheral blood mononuclear cells using high-density filter-based cDNA microarrays. J Immunol Methods. 2000, 239 (1-2): 167-179. 10.1016/S0022-1759(00)00181-2
Article
CAS
PubMed
Google Scholar
Walker LS, Chodos A, Eggena M, Dooms H, Abbas AK: Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med. 2003, 198 (2): 249-258. 10.1084/jem.20030315
Article
PubMed Central
CAS
PubMed
Google Scholar
Maloy KJ, Powrie F: Regulatory T cells in the control of immune pathology. Nat Immunol. 2001, 2 (9): 816-822. 10.1038/ni0901-816
Article
CAS
PubMed
Google Scholar
Setoguchi R, Hori S, Takahashi T, Sakaguchi S: Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005, 201 (5): 723-735. 10.1084/jem.20041982
Article
PubMed Central
CAS
PubMed
Google Scholar
Shaw AS: How T cells 'find' the right dendritic cell. Nat Immunol. 2008, 9 (3): 229-230. 10.1038/ni0308-229
Article
CAS
PubMed
Google Scholar
Abta R, Shnerb NM: Angular velocity variations and stability of spatially explicit prey-predator systems. Phys Rev E Stat Nonlin Soft Matter Phys. 2007, 75 (5 Pt 1): 051914-
Article
PubMed
Google Scholar
Reichenbach T, Mobilia M, Frey E: Coexistence versus extinction in the stochastic cyclic Lotka-Volterra model. Phys Rev E Stat Nonlin Soft Matter Phys. 2006, 74 (5 Pt 1): 051907-
Article
PubMed
Google Scholar
Rozenfeld AF, Albano EV: Critical and oscillatory behavior of a system of smart preys and predators. Phys Rev E Stat Nonlin Soft Matter Phys. 2001, 63 (6 Pt 1): 061907-
Article
CAS
PubMed
Google Scholar
Kyewski B, Klein L: A central role for central tolerance. Annu Rev Immunol. 2006, 24: 571-606. 10.1146/annurev.immunol.23.021704.115601
Article
CAS
PubMed
Google Scholar