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Systems physiology, pharmacology and medicine

Section edited by Christina Chan

This section covers the analysis and modeling of complex systems to better understand humans and animal biology, in particular with regard to human health and disease.

Page 1 of 4

  1. Content type: Research article

    Recent results from single cell gene and protein regulation studies are starting to uncover the previously underappreciated fact that individual cells within a population exhibit high variability in the expres...

    Authors: Daniel Cook, Sirisha Achanta, Jan B. Hoek, Babatunde A. Ogunnaike and Rajanikanth Vadigepalli

    Citation: BMC Systems Biology 2018 12:86

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  2. Content type: Research article

    A challenge of in vitro to in vivo extrapolation (IVIVE) is to predict the physical state of organisms exposed to chemicals in the environment from in vitro exposure assay data. Although toxicokinetic modeling...

    Authors: Michael A. Rowland, Hannah Wear, Karen H. Watanabe, Kurt A. Gust and Michael L. Mayo

    Citation: BMC Systems Biology 2018 12:81

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  3. Content type: Research article

    The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimetho...

    Authors: Guan-Sheng Liu, Richard Ballweg, Alan Ashbaugh, Yin Zhang, Joseph Facciolo, Melanie T. Cushion and Tongli Zhang

    Citation: BMC Systems Biology 2018 12:77

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  4. Content type: Research article

    Escherichia coli is considered a leading bacterial trigger of inflammatory bowel disease (IBD). E. coli isolates from IBD patients primarily belong to phylogroup B2. Previous studies have focused on broad compara...

    Authors: Xin Fang, Jonathan M. Monk, Nathan Mih, Bin Du, Anand V. Sastry, Erol Kavvas, Yara Seif, Larry Smarr and Bernhard O. Palsson

    Citation: BMC Systems Biology 2018 12:66

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  5. Content type: Review

    Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance...

    Authors: Frank Kramer, Steffen Just and Tanja Zeller

    Citation: BMC Systems Biology 2018 12:57

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  6. Content type: Research article

    Cell death as a result of ischemic injury triggers powerful mechanisms regulated by germline-encoded Pattern Recognition Receptors (PRRs) with shared specificity that recognize invading pathogens and endogenou...

    Authors: Elena Dimitrova, Leslie A. Caromile, Reinhard Laubenbacher and Linda H. Shapiro

    Citation: BMC Systems Biology 2018 12:50

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  7. Content type: Research article

    Progesterone plays an essential role in mammalian ovulation. Although much is known about this process, the gene networks involved in ovulation have yet to be established. When analyze the mechanisms of ovulat...

    Authors: Fang Yang, Meng Wang, Baoyun Zhang, Wei Xiang, Ke Zhang, Mingxin Chu and Pingqing Wang

    Citation: BMC Systems Biology 2018 12:36

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  8. Content type: Review Article

    Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “o...

    Authors: James T. Yurkovich, Aarash Bordbar, Ólafur E. Sigurjónsson and Bernhard O. Palsson

    Citation: BMC Systems Biology 2018 12:31

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  9. Content type: Research article

    With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics targeting potential human host factors.

    Authors: Zhang Wang, Seda Arat, Michal Magid-Slav and James R. Brown

    Citation: BMC Systems Biology 2018 12:3

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  10. Content type: Research Article

    Dengue virus (DENV) is an increasing global health threat and associated with induction of both a long-lived protective immune response and immune-suppression. So far, the potency of treatment of DENV via anti...

    Authors: Mohamed Shahen, Zihu Guo, Akhtar Hussain Shar, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao and Yonghua Wang

    Citation: BMC Systems Biology 2018 12:2

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    The Correction to this article has been published in BMC Systems Biology 2018 12:21

  11. Content type: Research article

    Osmanthus fragrans has been used as folk medicine for thousands of years. The extracts of Osmanthus fragrans flowers were reported to have various bioactivities including free radical ...

    Authors: Le Wang, Nana Tan, Jiayao Hu, Huan Wang, Dongzhu Duan, Lin Ma, Jian Xiao and Xiaoling Wang

    Citation: BMC Systems Biology 2017 11:144

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  12. Content type: Review

    Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural ...

    Authors: Massimo S. Fiandaca, Mark Mapstone, Elenora Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio Macciardi and Howard J. Federoff

    Citation: BMC Systems Biology 2017 11:142

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  13. Content type: Research Article

    Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and prolifer...

    Authors: Joanna H. Sier, Alfred E. Thumser and Nick J. Plant

    Citation: BMC Systems Biology 2017 11:141

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  14. Content type: Research Article

    Polygenic diseases are usually caused by the dysfunction of multiple genes. Unravelling such disease genes is crucial to fully understand the genetic landscape of diseases on molecular level. With the advent o...

    Authors: Limei Lin, Tinghong Yang, Ling Fang, Jian Yang, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:121

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  15. Content type: Research Article

    Particle size is a key parameter for drug-delivery nanoparticle design. It is believed that the size of a nanoparticle may have important effects on its ability to overcome the transport barriers in biological...

    Authors: Mohammad Aminul Islam, Sutapa Barua and Dipak Barua

    Citation: BMC Systems Biology 2017 11:113

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  16. Content type: Research Article

    Helicobacter Pylori (HP) is the most common risk factor for gastric cancer. Nearly half the world’s population is infected with HP, but only a small percentage of those develop significant pathology. The bacte...

    Authors: Richard Ballweg, Frederick Schozer, Kelsey Elliott, Alexander Kuhn, Logan Spotts, Eitaro Aihara and Tongli Zhang

    Citation: BMC Systems Biology 2017 11:111

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  17. Content type: Research Article

    Up to date, Mycobacterium tuberculosis (Mtb) remains as the worst intracellular killer pathogen. To establish infection, inside the granuloma, Mtb reprograms its metabolism to support both growth and survival, ke...

    Authors: Víctor A. López-Agudelo, Andres Baena, Howard Ramirez-Malule, Silvia Ochoa, Luis F. Barrera and Rigoberto Ríos-Estepa

    Citation: BMC Systems Biology 2017 11:107

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  18. Content type: Research Article

    Drug resistance mediated by P-glycoprotein (P-gp) renders many cancer therapies ineffective. One P-gp substrate is the widely used chemotherapy drug paclitaxel. Co-administration of paclitaxel and another drug...

    Authors: Joe Bender, Jianwen Fang and Richard Simon

    Citation: BMC Systems Biology 2017 11:108

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  19. Content type: Research Article

    Vitiligo is a long-term skin disease characterized by the loss of pigment in the skin. The current therapeutic approaches are limited. Although the anti-vitiligo mechanisms of Vernonia anthelmintica (L.) remain a...

    Authors: Ji Ye Wang, Hong Chen, Yin Yin Wang, Xiao Qin Wang, Han Ying Chen, Mei Zhang, Yun Tang and Bo Zhang

    Citation: BMC Systems Biology 2017 11:103

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  20. Content type: Research Article

    One goal of personalized medicine is leveraging the emerging tools of data science to guide medical decision-making. Achieving this using disparate data sources is most daunting for polygenic traits. To this e...

    Authors: Cihan Oguz, Shurjo K. Sen, Adam R. Davis, Yi-Ping Fu, Christopher J. O’Donnell and Gary H. Gibbons

    Citation: BMC Systems Biology 2017 11:99

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  21. Content type: Research Article

    Cells are able to communicate and coordinate their function within tissues via secreted factors. Aberrant secretion by cancer cells can modulate this intercellular communication, in particular in highly organi...

    Authors: Niklas Hartung, Uwe Benary, Jana Wolf and Bente Kofahl

    Citation: BMC Systems Biology 2017 11:98

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  22. Content type: Research Article

    Acute myelogenous leukemia (AML) progresses uniquely in each patient. However, patients are typically treated with the same types of chemotherapy, despite biological differences that lead to differential respo...

    Authors: Joyatee M. Sarker, Serena M. Pearce, Robert P. Nelson Jr., Tamara L. Kinzer-Ursem, David M. Umulis and Ann E. Rundell

    Citation: BMC Systems Biology 2017 11:78

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  23. Content type: Research Article

    The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker prot...

    Authors: Ranjita Dutta Roy, Christian Rosenmund and Melanie I. Stefan

    Citation: BMC Systems Biology 2017 11:74

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  24. Content type: Research Article

    Triple-negative breast cancer lacks estrogen, progesterone, and HER2 receptors and is thus not possible to treat with targeted therapies for these receptors. Therefore, a greater understanding of triple-negati...

    Authors: Kerri-Ann Norton, Travis Wallace, Niranjan B. Pandey and Aleksander S. Popel

    Citation: BMC Systems Biology 2017 11:68

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  25. Content type: Research Article

    α2-adrenoceptors are important regulators of vascular tone and blood pressure. Regulation of cell proliferation is a less well investigated consequence of α2-adrenoceptor activation. We have previously shown that...

    Authors: Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg and Mika Scheinin

    Citation: BMC Systems Biology 2017 11:65

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  26. Content type: Research article

    Type 2 diabetes is one of the leading non-infectious diseases worldwide and closely relates to excess adipose tissue accumulation as seen in obesity. Specifically, hypertrophic expansion of adipose tissues is ...

    Authors: Thierry Chénard, Frédéric Guénard, Marie-Claude Vohl, André Carpentier, André Tchernof and Rafael J. Najmanovich

    Citation: BMC Systems Biology 2017 11:60

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  27. Content type: Research Article

    The leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. This study develops a novel systems biology driven approach for killing antibiotic resistant pathogens...

    Authors: Deepanwita Banerjee, Dharmeshkumar Parmar, Nivedita Bhattacharya, Avinash D. Ghanate, Venkateswarlu Panchagnula and Anu Raghunathan

    Citation: BMC Systems Biology 2017 11:51

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  28. Content type: Research article

    Physiologically-based toxicokinetic (PBTK) models are often developed to facilitate in vitro to in vivo extrapolation (IVIVE) using a top-down, compartmental approach, favoring architectural simplicity over ph...

    Authors: Michael A. Rowland, Edward J. Perkins and Michael L. Mayo

    Citation: BMC Systems Biology 2017 11:35

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  29. Content type: Research article

    Although renal fibrosis and inflammation have shown to be involved in the pathophysiology of obstructive nephropathies, molecular mechanisms underlying evolution of these processes remain undetermined. In an a...

    Authors: Theofilos Papadopoulos, Audrey Casemayou, Eric Neau, Benjamin Breuil, Cécile Caubet, Denis Calise, Barbara A. Thornhill, Magdalena Bachvarova, Julie Belliere, Robert L. Chevalier, Panagiotis Moulos, Dimcho Bachvarov, Benedicte Buffin-Meyer, Stéphane Decramer, Françoise Conte Auriol, Jean-Loup Bascands…

    Citation: BMC Systems Biology 2017 11:31

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  30. Content type: Research article

    We contrast the pectoralis muscle transcriptomes of broilers selected from within a single genetic line expressing divergent feed efficiency (FE) in an effort to improve our understanding of the mechanistic basis...

    Authors: Walter Bottje, Byung-Whi Kong, Antonio Reverter, Ashley J. Waardenberg, Kentu Lassiter and Nicholas J. Hudson

    Citation: BMC Systems Biology 2017 11:29

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  31. Content type: Research Article

    Clostridium difficile is a bacterium which can infect various animal species, including humans. Infection with this bacterium is a leading healthcare-associated illness. A better under...

    Authors: Sara Saheb Kashaf, Claudio Angione and Pietro Lió

    Citation: BMC Systems Biology 2017 11:25

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  32. Content type: Research Article

    Alzheimer disease (AD) is a progressive neurodegenerative disease that destroys memory and cognitive skills. AD is characterized by the presence of two types of neuropathological hallmarks: extracellular plaqu...

    Authors: Wenrui Hao and Avner Friedman

    Citation: BMC Systems Biology 2016 10:108

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  33. Content type: Research Article

    Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for partur...

    Authors: Douglas Brubaker, Alethea Barbaro, Mark R. Chance and Sam Mesiano

    Citation: BMC Systems Biology 2016 10:79

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  34. Content type: Research article

    Development of resistance against first line drug therapy including cisplatin and paclitaxel in high-grade serous ovarian cancer (HGSOC) presents a major challenge. Identifying drug candidates breaking resista...

    Authors: Peter Andorfer, Alexander Heuwieser, Andreas Heinzel, Arno Lukas, Bernd Mayer and Paul Perco

    Citation: BMC Systems Biology 2016 10:33

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  35. Content type: Research article

    The success of genome-scale models (GEMs) can be attributed to the high-quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional regulatory networks on an organism-specific basis...

    Authors: Elizabeth Brunk, Nathan Mih, Jonathan Monk, Zhen Zhang, Edward J. O’Brien, Spencer E. Bliven, Ke Chen, Roger L. Chang, Philip E. Bourne and Bernhard O. Palsson

    Citation: BMC Systems Biology 2016 10:26

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  36. Content type: Research article

    As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) is found in high levels in ALL cells. Neve...

    Authors: Eleftherios Ouzounoglou, Dimitra Dionysiou and Georgios S. Stamatakos

    Citation: BMC Systems Biology 2016 10:23

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  37. Content type: Research article

    The insulin-like growth factor (IGF) system impacts cellular development by regulating proliferation, differentiation, and apoptosis, and is an attractive therapeutic target in cancer. The IGF system is comple...

    Authors: Dan Tian, Isaiah Mitchell and Pamela K. Kreeger

    Citation: BMC Systems Biology 2016 10:15

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  38. Content type: Research article

    Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities. Incomplete knowledge of antibiotic and host immune dynamics in ...

    Authors: Elsje Pienaar, Véronique Dartois, Jennifer J. Linderman and Denise E. Kirschner

    Citation: BMC Systems Biology 2015 9:79

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  39. Content type: Research article

    Cytokine-hormone network deregulations underpin pathologies ranging from autoimmune disorders to cancer, but our understanding of these networks in physiological/pathophysiological states remains patchy. We em...

    Authors: Sarah L. Field, Tathagata Dasgupta, Michele Cummings, Richard S. Savage, Julius Adebayo, Hema McSara, Jeremy Gunawardena and Nicolas M. Orsi

    Citation: BMC Systems Biology 2015 9:76

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  40. Content type: Research article

    A hallmark of chronic liver disease is the impairment of the liver’s innate regenerative ability. In this work we use a computational approach to unravel the principles underlying control of liver repair follo...

    Authors: Daniel Cook, Babatunde A. Ogunnaike and Rajanikanth Vadigepalli

    Citation: BMC Systems Biology 2015 9:71

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  41. Content type: Research Article

    Methyltransferase (MT) reactions, in which methyl groups are attached to substrates, are fundamental to many aspects of cell biology and human physiology. The universal methyl donor for these reactions is S-ad...

    Authors: Michael C. Reed, Mary V. Gamble, Megan N. Hall and H. Frederik Nijhout

    Citation: BMC Systems Biology 2015 9:69

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  42. Content type: Research article

    The vascular endothelial growth factor (VEGF) family is central to cancer angiogenesis. However, targeting VEGF as an anti-cancer therapeutic approach has shown success for some tumor types but not others. Her...

    Authors: R. Joseph Bender and Feilim Mac Gabhann

    Citation: BMC Systems Biology 2015 9:55

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  43. Content type: Research article

    Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dos...

    Authors: Sibylle Schirm, Christoph Engel, Markus Loeffler and Markus Scholz

    Citation: BMC Systems Biology 2014 8:138

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  44. Content type: Research article

    Given the complex nature of cardiovascular disease (CVD), information derived from a systems-level will allow us to fully interrogate features of CVD to better understand disease pathogenesis and to identify n...

    Authors: Peng Li, Yingxue Fu, Jinlong Ru, Chao Huang, Jiangfeng Du, Chunli Zheng, Xuetong Chen, Pidong Li, Aiping Lu, Ling Yang and Yonghua Wang

    Citation: BMC Systems Biology 2014 8:141

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  45. Content type: Research article

    It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial. We aimed to quantitatively analyse the effects of resis...

    Authors: Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet and Marta Cascante

    Citation: BMC Systems Biology 2014 8:109

    Published on:

2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)

    Usage 
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    Social Media Impact
    523 mentions

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