Donath M, Shoelson S: Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011, 11: 98-107. 10.1038/nri2925.
Article
CAS
PubMed
Google Scholar
Minamino T, Komuro I: Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Clin Pract Card. 2008, 5 (10): 637-648. 10.1038/ncpcardio1324.
Article
CAS
Google Scholar
Drüeke T, Massy Z: Atherosclerosis in CKD: differences from the general population. Nat Rev Nephrol. 2010, 6 (12): 723-735. 10.1038/nrneph.2010.143.
Article
PubMed
Google Scholar
Yeh M, Brunt E: Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol. 2007, 128 (5): 837-847. 10.1309/RTPM1PY6YGBL2G2R.
Article
PubMed
Google Scholar
Rutledge J, Ng K, Aung H, Wilson D: Role of triglyceride-rich lipoproteins in diabetic nephropathy. Nat Rev Nephrol. 2010, 6 (6): 361-370. 10.1038/nrneph.2010.59.
Article
CAS
PubMed
Google Scholar
Speakman J, Hambly C, Mitchell S, Krol E: The contribution of animal models to the study of obesity. Lab Anim. 2008, 42 (4): 413-432. 10.1258/la.2007.006067.
Article
CAS
PubMed
Google Scholar
Manis J: Knock out, knock in, knock down-genetically manipulated mice and the Nobel Prize. N Engl J Med. 2007, 357 (24): 2426-2429. 10.1056/NEJMp0707712.
Article
CAS
PubMed
Google Scholar
Voshol P, Rensen P, van Dijk K, Romijn J, Havekes L: Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models. Biochim Biophys Acta. 2009, 1791 (6): 479-485.
Article
CAS
PubMed
Google Scholar
Ilan Y, Maron R, Tukpah A, Maioli T, Murugaiyan G, Yang K, Wu H, Weiner H: Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. P Natl Acad Sci USA. 2010, 107 (21): 9765-9770. 10.1073/pnas.0908771107.
Article
CAS
Google Scholar
Zhang C, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig A, Boss O, Kim Y, et al, et al.: Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes. Cell. 2001, 105 (6): 745-755. 10.1016/S0092-8674(01)00378-6.
Article
CAS
PubMed
Google Scholar
De Luca C, Kowalski T, Zhang Y, Elmquist J, Lee C, Kilimann M, Ludwig T, Liu S, Chua Jr S: Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest. 2005, 115 (12): 3484-3493. 10.1172/JCI24059.
Article
PubMed Central
CAS
PubMed
Google Scholar
Banks A, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D: SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008, 8 (4): 333-341. 10.1016/j.cmet.2008.08.014.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fang X, Wallqvist A, Reifman J: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis. BMC Syst Biol. 2009, 3: 92-10.1186/1752-0509-3-92.
Article
PubMed Central
PubMed
Google Scholar
Wu X, Jiang R, Zhang M, Li S: Network-based global inference of human disease genes. Mol Syst Biol. 2008, 4: 189.
Article
PubMed Central
PubMed
Google Scholar
Young D, Stark J, Kirschner D: Systems biology of persistent infection: tuberculosis as a case study. Nat Rev Microbiol. 2008, 6 (7): 520-528. 10.1038/nrmicro1919.
Article
CAS
PubMed
Google Scholar
Lusis A, Attie A, Reue K: Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet. 2008, 9 (11): 819-830. 10.1038/nrg2468.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stefanini M, Wu F, Mac Gabhann F, Popel A: A compartment model of VEGF distribution in blood, healthy and diseased tissues. BMC Syst Biol. 2008, 2: 77-10.1186/1752-0509-2-77.
Article
PubMed Central
PubMed
Google Scholar
Hu P, Bader G, Wigle D, Emili A: Computational prediction of cancer-gene function. Nat Rev Cancer. 2006, 7: 23-34.
Article
CAS
PubMed
Google Scholar
Kitano H: Computational systems biology. Nature. 2002, 420 (6912): 206-210. 10.1038/nature01254.
Article
CAS
PubMed
Google Scholar
Schoeberl B, Eichler-Jonsson C, Gilles E, Müller G: Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol. 2002, 20 (4): 370-375. 10.1038/nbt0402-370.
Article
PubMed
Google Scholar
Koschorreck M, Gilles E: Mathematical modeling and analysis of insulin clearance in vivo. BMC Syst Biol. 2008, 2: 43-10.1186/1752-0509-2-43.
Article
PubMed Central
PubMed
Google Scholar
Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann W, Timmer J, Klingmüller U: Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol. 2009, 5: 334.
Article
PubMed Central
PubMed
Google Scholar
Borisov N, Aksamitiene E, Kiyatkin A, Legewie S, Berkhout J, Maiwald T, Kaimachnikov N, Timmer J, Hoek J, Kholodenko B: Systems-level interactions between insulin-EGF networks amplify mitogenic signaling. Mol Syst Biol. 2009, 5: 256.
Article
PubMed Central
PubMed
Google Scholar
Cedersund G, Roll J, Ulfhielm E, Danielsson A, Tidefelt H, Strålfors P: Model-based hypothesis testing of key mechanisms in initial phase of insulin signaling. PLoS Comput Biol. 2008, 4 (6): 799-806.
Article
Google Scholar
Repa J, Mangelsdorf D: The liver X receptor gene team: potential new players in atherosclerosis. Nat med. 2002, 8 (11): 1243-1248. 10.1038/nm1102-1243.
Article
CAS
PubMed
Google Scholar
Joseph S, Castrillo A, Laffitte B, Mangelsdorf D, Tontonoz P: Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat med. 2003, 9 (2): 213-219. 10.1038/nm820.
Article
CAS
PubMed
Google Scholar
Janowski B, Willy P, Devi T, Falck J, Mangelsdorf D: An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature. 1996, 383 (6602): 728-731. 10.1038/383728a0.
Article
CAS
PubMed
Google Scholar
Oosterveer M, Grefhorst A, Groen A, Kuipers F: The liver X receptor: Control of cellular lipid homeostasis and beyond: Implications for drug design. Prog Lipid Res. 2010, 49 (4): 343-352. 10.1016/j.plipres.2010.03.002.
Article
CAS
PubMed
Google Scholar
Grefhorst A, Elzinga B, Voshol P, Plösch T, Kok T, Bloks V, van der Sluijs F, Havekes L, Romijn J, Verkade H, et al, et al.: Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem. 2002, 277 (37): 34182-34190. 10.1074/jbc.M204887200.
Article
CAS
PubMed
Google Scholar
Grefhorst A, Parks E: Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice. J Lipid Res. 2009, 50 (7): 1374-1383. 10.1194/jlr.M800505-JLR200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ashyraliyev M, Fomekong-Nanfack Y, Kaandorp J, Blom J: Systems biology: parameter estimation for biochemical models. FEBS J. 2009, 276 (4): 886-902. 10.1111/j.1742-4658.2008.06844.x.
Article
CAS
PubMed
Google Scholar
Cedersund G, Roll J: Systems biology: model based evaluation and comparison of potential explanations for given biological data. FEBS J. 2009, 276 (4): 903-922. 10.1111/j.1742-4658.2008.06845.x.
Article
CAS
PubMed
Google Scholar
Raue A, Kreutz C, Maiwald T, Bachmann J, Schilling M, Klingmüller U, Timmer J: Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood. Bioinformatics. 2009, 25 (15): 1923-10.1093/bioinformatics/btp358.
Article
CAS
PubMed
Google Scholar
Gutenkunst R, Waterfall J, Casey F, Brown K, Myers C, Sethna J: Universally sloppy parameter sensitivities in systems biology models. PLoS Comput Biol. 2007, 3 (10): 1871-1878.
Article
CAS
PubMed
Google Scholar
Dunn O: Multiple comparisons among means. J Am Stat Assoc. 1961, 52-64.
Google Scholar
Osono Y, Woollett L, Herz J, Dietschy J: Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J Clin Invest. 1995, 95 (3): 1124-1132. 10.1172/JCI117760.
Article
PubMed Central
CAS
PubMed
Google Scholar
Millar J, Stone S, Tietge U, Tow B, Billheimer J, Wong J, Hamilton R, Farese R, Rader D: Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production. J Lipid Res. 2006, 47 (10): 2297-2305. 10.1194/jlr.M600213-JLR200.
Article
CAS
PubMed
Google Scholar
Oosterveer M, Van Dijk T, Tietge U, Boer T, Havinga R, Stellaard F, Groen A, Kuipers F, Reijngoud D: High fat feeding induces hepatic fatty acid elongation in mice. PLoS One. 2009, 4 (6): e6066-10.1371/journal.pone.0006066.
Article
PubMed Central
PubMed
Google Scholar
Wiegman C, Bandsma R, Ouwens M, van der Sluijs F, Havinga R, Boer T, Reijngoud D, Romijn J, Kuipers F: Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes. 2003, 52 (5): 1081-1089. 10.2337/diabetes.52.5.1081.
Article
CAS
PubMed
Google Scholar
Okazaki H, Goldstein J, Brown M, Liang G: LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size. J Biol Chem. 2010, 285 (9): 6801-10.1074/jbc.M109.079459.
Article
PubMed Central
CAS
PubMed
Google Scholar
Csete M, Doyle J: Bow ties, metabolism and disease. TRENDS in Biotechnology. 2004, 22 (9): 446-450. 10.1016/j.tibtech.2004.07.007.
Article
CAS
PubMed
Google Scholar
Kitano H, Oda K, Kimura T, Matsuoka Y, Csete M, Doyle J, Muramatsu M: Metabolic syndrome and robustness tradeoffs. Diabetes. 2004, 53 (suppl 3): S6.
Article
CAS
PubMed
Google Scholar
Conradi C, Flockerzi D, Raisch J: Multistationarity in the activation of a MAPK: Parametrizing the relevant region in parameter space. Mathematical biosciences. 2008, 211: 105-131. 10.1016/j.mbs.2007.10.004.
Article
CAS
PubMed
Google Scholar
Saez-Rodriguez J, Hammerle-Fickinger A, Dalal O, Klamt S, Gilles E, Conradi C: Multistability of signal transduction motifs. Systems Biology, IET. 2008, 2 (2): 80-93. 10.1049/iet-syb:20070012.
Article
CAS
Google Scholar
Wilhelm T: The smallest chemical reaction system with bistability. BMC Sys Biol. 2009, 3: 90-10.1186/1752-0509-3-90.
Article
Google Scholar
Schultz J, Tu H, Luk A, Repa J, Medina J, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf D, et al, et al.: Role of LXRs in control of lipogenesis. Genes Dev. 2000, 14 (22): 2831-2838. 10.1101/gad.850400.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chisholm J, Hong J, Mills S, Lawn R: The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003, 44 (11): 2039-2048. 10.1194/jlr.M300135-JLR200.
Article
CAS
PubMed
Google Scholar
Ou J, Tu H, Shan B, Luk A, DeBose-Boyd R, Bashmakov Y, Goldstein J, Brown M: Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. P Natl Acad Sci USA. 2001, 98 (11): 6027-6032. 10.1073/pnas.111138698.
Article
CAS
Google Scholar
Miao B, Zondlo S, Gibbs S, Cromley D, Hosagrahara V, Kirchgessner T, Billheimer J, Mukherjee R: Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator. J Lipid Res. 2004, 45 (8): 1410-1417. 10.1194/jlr.M300450-JLR200.
Article
CAS
PubMed
Google Scholar
Quinet E, Savio D, Halpern A, Chen L, Miller C, Nambi P: Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor. J Lipid Res. 2004, 45 (10): 1929-1942. 10.1194/jlr.M400257-JLR200.
Article
CAS
PubMed
Google Scholar
Gibbons G, Islam K, Pease R: Mobilisation of triacylglycerol stores. Biochim Biophys Acta. 2000, 1483: 37-57.
Article
CAS
PubMed
Google Scholar
Gibbons G, Bartlett S, Sparks C, Sparks J: Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes. Biochem J. 1992, 287 (Pt 3): 749-753.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wiggins D, Gibbons G: The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas. Biochem J. 1992, 284 (Pt 2): 457-462.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang L, Kuksis A, Myher J, Steiner G: Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies. J Lipid Res. 1995, 36: 125-136.
CAS
PubMed
Google Scholar
Lankester D, Brown A, Zammit V: Use of cytosolic triacylglycerol hydrolysis products and of exogenous fatty acid for the synthesis of triacylglycerol secreted by cultured rat hepatocytes. J Lipid Res. 1998, 39 (9): 1889-1895.
CAS
PubMed
Google Scholar
Yen C, Stone S, Koliwad S, Harris C, Farese R: Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008, 49 (11): 2283-2301. 10.1194/jlr.R800018-JLR200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Monetti M, Levin M, Watt M, Sajan M, Marmor S, Hubbard B, Stevens R, Bain J, Newgard C, Farese R, et al, et al.: Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007, 6: 69-78. 10.1016/j.cmet.2007.05.005.
Article
CAS
PubMed
Google Scholar
Smith S, Cases S, Jensen D, Chen H, Sande E, Tow B, Sanan D, Raber J, Eckel R, Farese R: Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000, 25: 87-90. 10.1038/75651.
Article
CAS
PubMed
Google Scholar
Cases S, Smith S, Zheng Y, Myers H, Lear S, Sande E, Novak S, Collins C, Welch C, Lusis A, et al, et al.: Identification of a gene encoding an acyl CoA: diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. P Natl Acad Sci USA. 1998, 95 (22): 13018-13023. 10.1073/pnas.95.22.13018.
Article
CAS
Google Scholar
Noble D: Modeling the heart-from genes to cells to the whole organ. Science. 2002, 295 (5560): 1678-1682. 10.1126/science.1069881.
Article
CAS
PubMed
Google Scholar
Kohl P, Noble D: Systems biology and the virtual physiological human. Mol Syst Biol. 2009, 5: 292.
Article
PubMed Central
PubMed
Google Scholar
Hunter P, Borg T: Integration from proteins to organs: the Physiome Project. Nat Rev Mol Cell Bio. 2003, 4 (3): 237-243. 10.1038/nrm1054.
Article
CAS
Google Scholar
Kuepfer L: Towards whole-body systems physiology. Mol Syst Biol. 2010, 6: 409.
Article
PubMed Central
PubMed
Google Scholar
De Graaf A, Freidig A, De Roos B, Jamshidi N, Heinemann M, Rullmann J, Hall K, Adiels M, Van Ommen B: Nutritional systems biology modeling: from molecular mechanisms to physiology. PLoS Comput Biol. 2009, 5 (11): e1000554-10.1371/journal.pcbi.1000554.
Article
PubMed Central
PubMed
Google Scholar
Vincent N, de Chassey Benoit C, Vincent L: When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases. BMC Syst Biol. 2011, 5: 13-10.1186/1752-0509-5-13.
Article
Google Scholar