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BMC Systems Biology

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  1. Content type: Research

    The boundary formation in the Drosophila large intestine is widely studied as an important biological problem. It has been shown that the Delta-Notch signaling pathway plays an essential role in the formation of ...

    Authors: Fei Liu, Deshun Sun, Ryutaro Murakami and Hiroshi Matsuno

    Citation: BMC Systems Biology 2017 11(Suppl 4):80

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  2. Content type: Research

    The human phenome has been widely used with a variety of genomic data sources in the inference of disease genes. However, most existing methods thus far derive phenotype similarity based on the analysis of bio...

    Authors: Mingxin Gan, Wenran Li, Wanwen Zeng, Xiaojian Wang and Rui Jiang

    Citation: BMC Systems Biology 2017 11(Suppl 4):76

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  3. Content type: Research

    The Notch family of proteins plays a vital role in determining cell fates, such as proliferation, differentiation, and apoptosis. It has been shown that Notch1 and its ligands, Dll1 and Jag1, are overexpressed...

    Authors: Xiaofei Shi and Ruiqi Wang

    Citation: BMC Systems Biology 2017 11(Suppl 4):84

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  4. Content type: Research

    Predicting protein structure from amino acid sequence is a prominent problem in computational biology. The long range interactions (or non-local interactions) are known as the main source of complexity for pro...

    Authors: Yuzhen Guo, Fengying Tao, Zikai Wu and Yong Wang

    Citation: BMC Systems Biology 2017 11(Suppl 4):93

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  5. Content type: Research

    High-throughput experimental techniques have been dramatically improved and widely applied in the past decades. However, biological interpretation of the high-throughput experimental results, such as different...

    Authors: Duanchen Sun, Yinliang Liu, Xiang-Sun Zhang and Ling-Yun Wu

    Citation: BMC Systems Biology 2017 11(Suppl 4):75

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  6. Content type: Research

    The Algorithm for the Reconstruction of Accurate Cellular Networks (ARACNE) represents one of the most effective tools to reconstruct gene regulatory networks from large-scale molecular profile datasets. Howev...

    Authors: Jing He, Zhou Zhou, Michael Reed and Andrea Califano

    Citation: BMC Systems Biology 2017 11(Suppl 4):83

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  7. Content type: Research

    Influenza A virus is prone to mutation and susceptible to human beings and spread in the crowds when affected by the external environment or other factors. It is very necessary to forecast influenza A pandemic...

    Authors: Jie Gao, Kang Wang, Tao Ding and Shanshan Zhu

    Citation: BMC Systems Biology 2017 11(Suppl 4):85

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 4

  8. Content type: Research Article

    Acute myelogenous leukemia (AML) progresses uniquely in each patient. However, patients are typically treated with the same types of chemotherapy, despite biological differences that lead to differential respo...

    Authors: Joyatee M. Sarker, Serena M. Pearce, Robert P. Nelson Jr., Tamara L. Kinzer-Ursem, David M. Umulis and Ann E. Rundell

    Citation: BMC Systems Biology 2017 11:78

    Published on:

  9. Content type: Research Article

    The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker prot...

    Authors: Ranjita Dutta Roy, Christian Rosenmund and Melanie I. Stefan

    Citation: BMC Systems Biology 2017 11:74

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  10. Content type: Methodology Article

    High-throughput assays are widely used in biological research to select potential targets. One single high-throughput experiment can efficiently study a large number of candidates simultaneously, but is subjec...

    Authors: Wenfei Zhang, Ying Liu, Mindy Zhang, Cheng Zhu and Yuefeng Lu

    Citation: BMC Systems Biology 2017 11:73

    Published on:

  11. Content type: Methodology Article

    Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they f...

    Authors: Leonie Amstein, Jörg Ackermann, Jennifer Scheidel, Simone Fulda, Ivan Dikic and Ina Koch

    Citation: BMC Systems Biology 2017 11:72

    Published on:

  12. Content type: Research Article

    A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to th...

    Authors: Anna Doloman, Honey Varghese, Charles D. Miller and Nicholas S. Flann

    Citation: BMC Systems Biology 2017 11:69

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  13. Content type: Research Article

    Large sets of protein-protein interaction data coming either from biological experiments or predictive methods are available and can be combined to construct networks from which information about various cell ...

    Authors: Annie Glatigny, Philippe Gambette, Alexa Bourand-Plantefol, Geneviève Dujardin and Marie-Hélène Mucchielli-Giorgi

    Citation: BMC Systems Biology 2017 11:67

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  14. Content type: Research Article

    Triple-negative breast cancer lacks estrogen, progesterone, and HER2 receptors and is thus not possible to treat with targeted therapies for these receptors. Therefore, a greater understanding of triple-negati...

    Authors: Kerri-Ann Norton, Travis Wallace, Niranjan B. Pandey and Aleksander S. Popel

    Citation: BMC Systems Biology 2017 11:68

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  15. Content type: Research Article

    Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga which has become a biotechnological target because of its high capacity to produce polyunsaturated fatty acids and tr...

    Authors: Nicolás Loira, Sebastian Mendoza, María Paz Cortés, Natalia Rojas, Dante Travisany, Alex Di Genova, Natalia Gajardo, Nicole Ehrenfeld and Alejandro Maass

    Citation: BMC Systems Biology 2017 11:66

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  16. Content type: Research Article

    α2-adrenoceptors are important regulators of vascular tone and blood pressure. Regulation of cell proliferation is a less well investigated consequence of α2-adrenoceptor activation. We have previously shown that...

    Authors: Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg and Mika Scheinin

    Citation: BMC Systems Biology 2017 11:65

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  17. Content type: Research article

    Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-...

    Authors: Mariana E. Martinez-Sanchez, Marcia Hiriart and Elena R. Alvarez-Buylla

    Citation: BMC Systems Biology 2017 11:64

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  18. Content type: Research Article

    In quantitative biology, mathematical models are used to describe and analyze biological processes. The parameters of these models are usually unknown and need to be estimated from experimental data using stat...

    Authors: Benjamin Ballnus, Sabine Hug, Kathrin Hatz, Linus Görlitz, Jan Hasenauer and Fabian J. Theis

    Citation: BMC Systems Biology 2017 11:63

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  19. Content type: Methodology Article

    Co-expression has been widely used to identify novel regulatory relationships using high throughput measurements, such as microarray and RNA-seq data. Evaluation studies on co-expression network analysis metho...

    Authors: Wenbin Guo, Cristiane P. G. Calixto, Nikoleta Tzioutziou, Ping Lin, Robbie Waugh, John W. S. Brown and Runxuan Zhang

    Citation: BMC Systems Biology 2017 11:62

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  20. Content type: Software

    Finding gene-disease and disease-disease associations play important roles in the biomedical area and many prioritization methods have been proposed for this goal. Among them, approaches based on a heterogeneo...

    Authors: Duc-Hau Le and Van-Huy Pham

    Citation: BMC Systems Biology 2017 11:61

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  21. Content type: Research article

    Type 2 diabetes is one of the leading non-infectious diseases worldwide and closely relates to excess adipose tissue accumulation as seen in obesity. Specifically, hypertrophic expansion of adipose tissues is ...

    Authors: Thierry Chénard, Frédéric Guénard, Marie-Claude Vohl, André Carpentier, André Tchernof and Rafael J. Najmanovich

    Citation: BMC Systems Biology 2017 11:60

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  22. Content type: Research article

    The yeast AMPK/SNF1 pathway is best known for its role in glucose de/repression. When glucose becomes limited, the Snf1 kinase is activated and phosphorylates the transcriptional repressor Mig1, which is then ...

    Authors: Niek Welkenhuysen, Johannes Borgqvist, Mattias Backman, Loubna Bendrioua, Mattias Goksör, Caroline B Adiels, Marija Cvijovic and Stefan Hohmann

    Citation: BMC Systems Biology 2017 11:59

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  23. Content type: Research Article

    The increase in glycerol obtained as a byproduct of biodiesel has encouraged the production of new industrial products, such as 1,3-propanediol (PDO), using biotechnological transformation via bacteria like Clost...

    Authors: Luis Miguel Serrano-Bermúdez, Andrés Fernando González Barrios, Costas D. Maranas and Dolly Montoya

    Citation: BMC Systems Biology 2017 11:58

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