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Synthetic biology

Section edited by Sang Yup Lee

This section covers the application of systems biology, biotechnology and an engineering approach to the design and construction of novel biological functions, and in particular those with industrial or biomedical importance.

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  1. Content type: Research article

    The koji mold, Aspergillus oryzae is widely used for the production of industrial enzymes due to its particularly high protein secretion capacity and ability to perform post-translational modifications. However, ...

    Authors: Lifang Liu, Amir Feizi, Tobias Österlund, Carsten Hjort and Jens Nielsen

    Citation: BMC Systems Biology 2014 8:73

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  2. Content type: Research article

    The gut microbiota plays an important role in human health and disease by acting as a metabolic organ. Metagenomic sequencing has shown how dysbiosis in the gut microbiota is associated with human metabolic di...

    Authors: Ibrahim E El-Semman, Fredrik H Karlsson, Saeed Shoaie, Intawat Nookaew, Taysir H Soliman and Jens Nielsen

    Citation: BMC Systems Biology 2014 8:41

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  3. Content type: Methodology article

    Heterologous gene expression is an important tool for synthetic biology that enables metabolic engineering and the production of non-natural biologics in a variety of host organisms. The translational efficien...

    Authors: Amanda M Lanza, Kathleen A Curran, Lindsey G Rey and Hal S Alper

    Citation: BMC Systems Biology 2014 8:33

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  4. Content type: Research article

    Contact-dependent inhibition (CDI) has been recently revealed as an intriguing but ubiquitous mechanism for bacterial competition in which a species injects toxins into its competitors through direct physical ...

    Authors: Andrew E Blanchard, Venhar Celik and Ting Lu

    Citation: BMC Systems Biology 2014 8:23

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  5. Content type: Research article

    Cyanobacteria are photoautotrophic prokaryotes that exhibit robust growth under diverse environmental conditions with minimal nutritional requirements. They can use solar energy to convert CO2 and other reduced c...

    Authors: Thomas J Mueller, Bertram M Berla, Himadri B Pakrasi and Costas D Maranas

    Citation: BMC Systems Biology 2013 7:142

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  6. Content type: Methodology article

    Metabolic control analysis (MCA) and supply–demand theory have led to appreciable understanding of the systems properties of metabolic networks that are subject exclusively to metabolic regulation. Supply–dema...

    Authors: Fei He, Vincent Fromion and Hans V Westerhoff

    Citation: BMC Systems Biology 2013 7:131

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  7. Content type: Research article

    Synthetic genetic transistors are vital for signal amplification and switching in genetic circuits. However, it is still problematic to efficiently select the adequate promoters, Ribosome Binding Sides (RBSs) ...

    Authors: Yi-Ying Lee, Chih-Yuan Hsu, Ling-Jiun Lin, Chih-Chun Chang, Hsiao-Chun Cheng, Tsung-Hsien Yeh, Rei-Hsing Hu, Che Lin, Zhen Xie and Bor-Sen Chen

    Citation: BMC Systems Biology 2013 7:109

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  8. Content type: Research article

    Organisms have evolved ways of regulating transcription to better adapt to varying environments. Could the current functional genomics data and models support the possibility of engineering a genome with compl...

    Authors: Javier Carrera and Alfonso Jaramillo

    Citation: BMC Systems Biology 2013 7:108

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  9. Content type: Methodology article

    The modular design of synthetic gene circuits via composable parts (DNA segments) and pools of signal carriers (molecules such as RNA polymerases and ribosomes) has been successfully applied to bacterial syste...

    Authors: Mario Andrea Marchisio, Moreno Colaiacovo, Ellis Whitehead and Jörg Stelling

    Citation: BMC Systems Biology 2013 7:42

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  10. Content type: Research article

    An important step in strain optimization is to identify reactions whose activities should be modified to achieve the desired cellular objective. Preferably, these reactions are identified systematically, as th...

    Authors: Mona Yousofshahi, Michael Orshansky, Kyongbum Lee and Soha Hassoun

    Citation: BMC Systems Biology 2013 7:29

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  11. Content type: Research article

    Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to ...

    Authors: Sven EF Borgos, Sergio Bordel, Håvard Sletta, Helga Ertesvåg, Øyvind Jakobsen, Per Bruheim, Trond E Ellingsen, Jens Nielsen and Svein Valla

    Citation: BMC Systems Biology 2013 7:19

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  12. Content type: Research article

    Several studies have shown that the utilization of mixed carbon feeds instead of methanol as sole carbon source is beneficial for protein production with the methylotrophic yeast Pichia pastoris. In particular, g...

    Authors: Joel Jordà, Camilo Suarez, Marc Carnicer, Angela ten Pierick, Joseph J Heijnen, Walter van Gulik, Pau Ferrer, Joan Albiol and Aljoscha Wahl

    Citation: BMC Systems Biology 2013 7:17

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  13. Content type: Research article

    MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad ran...

    Authors: Carla Bosia, Matteo Osella, Mariama El Baroudi, Davide Corà and Michele Caselle

    Citation: BMC Systems Biology 2012 6:131

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  14. Content type: Research article

    Engineering genetic Boolean logic circuits is a major research theme of synthetic biology. By altering or introducing connections between genetic components, novel regulatory networks are built in order to mim...

    Authors: Angel Goñi-Moreno and Martyn Amos

    Citation: BMC Systems Biology 2012 6:126

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  15. Content type: Methodology article

    Elementary mode (EM) analysis is ideally suited for metabolic engineering as it allows for an unbiased decomposition of metabolic networks in biologically meaningful pathways. Recently, constrained minimal cut...

    Authors: Christian Jungreuthmayer and Jürgen Zanghellini

    Citation: BMC Systems Biology 2012 6:103

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2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    1233 Usage Factor

    Social Media Impact
    134 mentions