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Synthetic biology

Section edited by Sang Yup Lee

This section covers the application of systems biology, biotechnology and an engineering approach to the design and construction of novel biological functions, and in particular those with industrial or biomedical importance.

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  1. Design of newly engineered microbial strains for biotechnological purposes would greatly benefit from the development of realistic mathematical models for the processes to be optimized. Such models can then be...

    Authors: Carlos Pozo, Alberto Marín-Sanguino, Rui Alves, Gonzalo Guillén-Gosálbez, Laureano Jiménez and Albert Sorribas
    Citation: BMC Systems Biology 2011 5:137
  2. In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observe...

    Authors: Rutger D Douma, Joana M Batista, Kai M Touw, Jan AKW Kiel, Arjen M Krikken, Zheng Zhao, Tânia Veiga, Paul Klaassen, Roel AL Bovenberg, Jean-Marc Daran, Joseph J Heijnen and Walter M van Gulik
    Citation: BMC Systems Biology 2011 5:132
  3. The yeast Saccharomyces cerevisiae responds to amino acid starvation by inducing the transcription factor Gcn4. This is mainly mediated via a translational control mechanism dependent upon the translation initiat...

    Authors: Tao You, Ian Stansfield, M Carmen Romano, Alistair JP Brown and George M Coghill
    Citation: BMC Systems Biology 2011 5:131
  4. Solventogenic clostridia offer a sustainable alternative to petroleum-based production of butanol--an important chemical feedstock and potential fuel additive or replacement. C. beijerinckii is an attractive micr...

    Authors: Caroline B Milne, James A Eddy, Ravali Raju, Soroush Ardekani, Pan-Jun Kim, Ryan S Senger, Yong-Su Jin, Hans P Blaschek and Nathan D Price
    Citation: BMC Systems Biology 2011 5:130
  5. Synthetic biology is used to develop cell factories for production of chemicals by constructively importing heterologous pathways into industrial microorganisms. In this work we present a retrosynthetic approa...

    Authors: Pablo Carbonell, Anne-Gaëlle Planson, Davide Fichera and Jean-Loup Faulon
    Citation: BMC Systems Biology 2011 5:122
  6. Higher plants and algae are able to fix atmospheric carbon dioxide through photosynthesis and store this fixed carbon in large quantities as starch, which can be hydrolyzed into sugars serving as feedstock for...

    Authors: Ambarish Nag, Monte Lunacek, Peter A Graf and Christopher H Chang
    Citation: BMC Systems Biology 2011 5:94
  7. Every phenotypic trait can be viewed as a "system" in which a group of interconnected components function synergistically to yield a unified whole. Once a system's components and their interactions have been d...

    Authors: Rongling Wu, Jiguo Cao, Zhongwen Huang, Zhong Wang, Junyi Gai and Eduardo Vallejos
    Citation: BMC Systems Biology 2011 5:84