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Synthetic biology

Section edited by Sang Yup Lee

This section covers the application of systems biology, biotechnology and an engineering approach to the design and construction of novel biological functions, and in particular those with industrial or biomedical importance.

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  1. Content type: Research article

    In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observe...

    Authors: Rutger D Douma, Joana M Batista, Kai M Touw, Jan AKW Kiel, Arjen M Krikken, Zheng Zhao, Tânia Veiga, Paul Klaassen, Roel AL Bovenberg, Jean-Marc Daran, Joseph J Heijnen and Walter M van Gulik

    Citation: BMC Systems Biology 2011 5:132

    Published on:

  2. Content type: Research article

    The yeast Saccharomyces cerevisiae responds to amino acid starvation by inducing the transcription factor Gcn4. This is mainly mediated via a translational control mechanism dependent upon the translation initiat...

    Authors: Tao You, Ian Stansfield, M Carmen Romano, Alistair JP Brown and George M Coghill

    Citation: BMC Systems Biology 2011 5:131

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  3. Content type: Research article

    Solventogenic clostridia offer a sustainable alternative to petroleum-based production of butanol--an important chemical feedstock and potential fuel additive or replacement. C. beijerinckii is an attractive micr...

    Authors: Caroline B Milne, James A Eddy, Ravali Raju, Soroush Ardekani, Pan-Jun Kim, Ryan S Senger, Yong-Su Jin, Hans P Blaschek and Nathan D Price

    Citation: BMC Systems Biology 2011 5:130

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  4. Content type: Methodology article

    Synthetic biology is used to develop cell factories for production of chemicals by constructively importing heterologous pathways into industrial microorganisms. In this work we present a retrosynthetic approa...

    Authors: Pablo Carbonell, Anne-Gaëlle Planson, Davide Fichera and Jean-Loup Faulon

    Citation: BMC Systems Biology 2011 5:122

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  5. Content type: Research article

    Higher plants and algae are able to fix atmospheric carbon dioxide through photosynthesis and store this fixed carbon in large quantities as starch, which can be hydrolyzed into sugars serving as feedstock for...

    Authors: Ambarish Nag, Monte Lunacek, Peter A Graf and Christopher H Chang

    Citation: BMC Systems Biology 2011 5:94

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  6. Content type: Methodology article

    Every phenotypic trait can be viewed as a "system" in which a group of interconnected components function synergistically to yield a unified whole. Once a system's components and their interactions have been d...

    Authors: Rongling Wu, Jiguo Cao, Zhongwen Huang, Zhong Wang, Junyi Gai and Eduardo Vallejos

    Citation: BMC Systems Biology 2011 5:84

    Published on:

2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)


    Social Media Impact
    523 mentions