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BMC Systems Biology

Networks and information flow

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  1. Content type: Research Article

    Biochemical oscillations play an important role in maintaining physiological and cellular homeostasis in biological systems. The frequency and amplitude of oscillations are regulated to properly adapt to envir...

    Authors: Jun Hyuk Kang and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:95

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  2. Content type: Methodology Article

    Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they f...

    Authors: Leonie Amstein, Jörg Ackermann, Jennifer Scheidel, Simone Fulda, Ivan Dikic and Ina Koch

    Citation: BMC Systems Biology 2017 11:72

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  3. Content type: Research article

    Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-...

    Authors: Mariana E. Martinez-Sanchez, Marcia Hiriart and Elena R. Alvarez-Buylla

    Citation: BMC Systems Biology 2017 11:64

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  4. Content type: Research Article

    The human gut contains approximately 1014 bacteria, belonging to hundreds of different species. Together, these microbial species form a complex food web that can break down nutrient sources that our own digestiv...

    Authors: Milan J. A. van Hoek and Roeland M. H. Merks

    Citation: BMC Systems Biology 2017 11:56

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  5. Content type: Database

    Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction i...

    Authors: Abraham A. Labena, Yuan-Nong Ye, Chuan Dong, Fa-Z Zhang and Feng-Biao Guo

    Citation: BMC Systems Biology 2017 11:50

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  6. Content type: Research Article

    Cancer reversion, converting the phenotypes of a cancer cell into those of a normal cell, has been sporadically observed throughout history. However, no systematic analysis has been attempted so far.

    Authors: Yunseong Kim, Sea Choi, Dongkwan Shin and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:45

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  7. Content type: Research article

    Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments. The elucidation of the cell biolo...

    Authors: Anne Mathilde Lund, Christian Schrøder Kaas, Julian Brandl, Lasse Ebdrup Pedersen, Helene Faustrup Kildegaard, Claus Kristensen and Mikael Rørdam Andersen

    Citation: BMC Systems Biology 2017 11:37

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  8. Content type: Research article

    Gain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysm...

    Authors: Dimos Kapetis, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N. Xenakis, Ronald L. Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G. Faber, Monique Gerrits, Ingemar S. J. Merkies, Sulayman D. Dib-Hajj, Massimo Mantegazza, Stephen G. Waxman and Giuseppe Lauria

    Citation: BMC Systems Biology 2017 11:28

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  9. Content type: Research article

    Physical and functional interplays between genes or proteins have important biological meaning for cellular functions. Some efforts have been made to construct weighted gene association meta-networks by integr...

    Authors: Jian Yang, Tinghong Yang, Duzhi Wu, Limei Lin, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:12

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  10. Content type: Research article

    Computational, genome based predictions of organism phenotypes has enhanced the ability to investigate the biological phenomena that help organisms survive and respond to their environments. In this study, we ...

    Authors: Joseph J. Gardner and Nanette R. Boyle

    Citation: BMC Systems Biology 2017 11:4

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  11. Content type: Research Article

    As metabolic pathway resources become more commonly available, researchers have unprecedented access to information about their organism of interest. Despite efforts to ensure consistency between various resou...

    Authors: Jesse R. Walsh, Mary L. Schaeffer, Peifen Zhang, Seung Y. Rhee, Julie A. Dickerson and Taner Z. Sen

    Citation: BMC Systems Biology 2016 10:129

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  12. Content type: Research article

    Corynebacterium pseudotuberculosis (Cp) is a gram-positive bacterium that is classified into equi and ovis serovars. The serovar ovis is the etiological agent of caseous lymphadenitis,...

    Authors: Edson Luiz Folador, Paulo Vinícius Sanches Daltro de Carvalho, Wanderson Marques Silva, Rafaela Salgado Ferreira, Artur Silva, Michael Gromiha, Preetam Ghosh, Debmalya Barh, Vasco Azevedo and Richard Röttger

    Citation: BMC Systems Biology 2016 10:103

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  13. Content type: Research article

    During the last decades, we face an increasing interest in superior plants to supply growing demands for human and animal nutrition and for the developing bio-based economy. Presently, our limited understandin...

    Authors: Veronique Beckers, Lisa Maria Dersch, Katrin Lotz, Guido Melzer, Oliver Ernst Bläsing, Regine Fuchs, Thomas Ehrhardt and Christoph Wittmann

    Citation: BMC Systems Biology 2016 10:102

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  14. Content type: Research article

    The complex interplay between viral replication and host immune response during infection remains poorly understood. While many viruses are known to employ anti-immune strategies to facilitate their replicatio...

    Authors: Jason E. McDermott, Hugh D. Mitchell, Lisa E. Gralinski, Amie J. Eisfeld, Laurence Josset, Armand Bankhead III, Gabriele Neumann, Susan C. Tilton, Alexandra Schäfer, Chengjun Li, Shufang Fan, Shannon McWeeney, Ralph S. Baric, Michael G. Katze and Katrina M. Waters

    Citation: BMC Systems Biology 2016 10:93

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  15. Content type: Research Article

    Identifying the gene regulatory networks governing the workings and identity of cells is one of the main challenges in understanding processes such as cellular differentiation, reprogramming or cancerogenesis....

    Authors: Maryam Nazarieh, Andreas Wiese, Thorsten Will, Mohamed Hamed and Volkhard Helms

    Citation: BMC Systems Biology 2016 10:88

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