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Networks and information flow

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  1. Content type: Research article

    Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have bee...

    Authors: Yuqi Zhao, Deepali Jhamb, Le Shu, Douglas Arneson, Deepak K. Rajpal and Xia Yang

    Citation: BMC Systems Biology 2019 13:8

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  2. Content type: Research article

    Omics data provide deep insights into overall biological processes of organisms. However, integration of data from different molecular levels such as transcriptomics and proteomics, still remains challenging. ...

    Authors: T. Conrad, O. Kniemeyer, S. G. Henkel, T. Krüger, D. J. Mattern, V. Valiante, R. Guthke, I. D. Jacobsen, A. A. Brakhage, S. Vlaic and J. Linde

    Citation: BMC Systems Biology 2018 12:88

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  3. Content type: Research article

    Carbon catabolite repression (CCR) controls the order in which different carbon sources are metabolised. Although this system is one of the paradigms of regulation in bacteria, the underlying mechanisms remain...

    Authors: Andreas Kremling, Johannes Geiselmann, Delphine Ropers and Hidde de Jong

    Citation: BMC Systems Biology 2018 12:82

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  4. Content type: Research article

    Numerous centrality measures have been introduced to identify “central” nodes in large networks. The availability of a wide range of measures for ranking influential nodes leaves the user to decide which measu...

    Authors: Minoo Ashtiani, Ali Salehzadeh-Yazdi, Zahra Razaghi-Moghadam, Holger Hennig, Olaf Wolkenhauer, Mehdi Mirzaie and Mohieddin Jafari

    Citation: BMC Systems Biology 2018 12:80

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  5. Content type: Research article

    The hypothalamic-pituitary-adrenal (HPA) axis is a central regulator of stress response and its dysfunction has been associated with a broad range of complex illnesses including Gulf War Illness (GWI) and Chro...

    Authors: Hooman Sedghamiz, Matthew Morris, Travis J. A. Craddock, Darrell Whitley and Gordon Broderick

    Citation: BMC Systems Biology 2018 12:76

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  6. Content type: Research article

    Reaction gap filling is a computational technique for proposing the addition of reactions to genome-scale metabolic models to permit those models to run correctly. Gap filling completes what are otherwise inco...

    Authors: Peter D. Karp, Daniel Weaver and Mario Latendresse

    Citation: BMC Systems Biology 2018 12:73

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  7. Content type: Research article

    Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between...

    Authors: Rosa D. Hernansaiz-Ballesteros, Luca Cardelli and Attila Csikász-Nagy

    Citation: BMC Systems Biology 2018 12:70

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  8. Content type: Regular article

    Atrial fibrillation is a cardiac disease driven by numerous idiopathic etiologies. NUP155 is a nuclear pore complex protein that has been identified as a clinical driver of atrial fibrillation, yet the precise...

    Authors: Claudia C. Preston, Saranya P. Wyles, Santiago Reyes, Emily C. Storm, Bruce W. Eckloff and Randolph S. Faustino

    Citation: BMC Systems Biology 2018 12:62

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  9. Content type: Research article

    For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) with...

    Authors: Alessandra Ordinelli, Nicola Bernabò, Massimiliano Orsini, Mauro Mattioli and Barbara Barboni

    Citation: BMC Systems Biology 2018 12:52

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  10. Content type: Research article

    Controlling complex molecular regulatory networks is getting a growing attention as it can provide a systematic way of driving any cellular state to a desired cell phenotypic state. A number of recent studies ...

    Authors: Sang-Mok Choo, Byunghyun Ban, Jae Il Joo and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2018 12:49

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  11. Content type: Methodology Article

    Many mathematical models have now been employed across every area of systems biology. These models increasingly involve large numbers of unknown parameters, have complex structure which can result in substanti...

    Authors: Ian Vernon, Junli Liu, Michael Goldstein, James Rowe, Jen Topping and Keith Lindsey

    Citation: BMC Systems Biology 2018 12:1

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  12. Content type: Research Article

    Cellular behaviors are governed by interaction networks among biomolecules, for example gene regulatory and signal transduction networks. An often used dynamic modeling framework for these networks, Boolean mo...

    Authors: Parul Maheshwari and Réka Albert

    Citation: BMC Systems Biology 2017 11:122

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  13. Content type: Research Article

    Biochemical oscillations play an important role in maintaining physiological and cellular homeostasis in biological systems. The frequency and amplitude of oscillations are regulated to properly adapt to envir...

    Authors: Jun Hyuk Kang and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:95

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  14. Content type: Methodology Article

    Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they f...

    Authors: Leonie Amstein, Jörg Ackermann, Jennifer Scheidel, Simone Fulda, Ivan Dikic and Ina Koch

    Citation: BMC Systems Biology 2017 11:72

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  15. Content type: Research article

    Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-...

    Authors: Mariana E. Martinez-Sanchez, Marcia Hiriart and Elena R. Alvarez-Buylla

    Citation: BMC Systems Biology 2017 11:64

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  16. Content type: Research Article

    The human gut contains approximately 1014 bacteria, belonging to hundreds of different species. Together, these microbial species form a complex food web that can break down nutrient sources that our own digestiv...

    Authors: Milan J. A. van Hoek and Roeland M. H. Merks

    Citation: BMC Systems Biology 2017 11:56

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  17. Content type: Database

    Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction i...

    Authors: Abraham A. Labena, Yuan-Nong Ye, Chuan Dong, Fa-Z Zhang and Feng-Biao Guo

    Citation: BMC Systems Biology 2017 11:50

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  18. Content type: Research Article

    Cancer reversion, converting the phenotypes of a cancer cell into those of a normal cell, has been sporadically observed throughout history. However, no systematic analysis has been attempted so far.

    Authors: Yunseong Kim, Sea Choi, Dongkwan Shin and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:45

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  19. Content type: Research article

    Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments. The elucidation of the cell biolo...

    Authors: Anne Mathilde Lund, Christian Schrøder Kaas, Julian Brandl, Lasse Ebdrup Pedersen, Helene Faustrup Kildegaard, Claus Kristensen and Mikael Rørdam Andersen

    Citation: BMC Systems Biology 2017 11:37

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  20. Content type: Research article

    Gain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysm...

    Authors: Dimos Kapetis, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N. Xenakis, Ronald L. Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G. Faber, Monique Gerrits, Ingemar S. J. Merkies, Sulayman D. Dib-Hajj, Massimo Mantegazza, Stephen G. Waxman and Giuseppe Lauria

    Citation: BMC Systems Biology 2017 11:28

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  21. Content type: Research article

    Physical and functional interplays between genes or proteins have important biological meaning for cellular functions. Some efforts have been made to construct weighted gene association meta-networks by integr...

    Authors: Jian Yang, Tinghong Yang, Duzhi Wu, Limei Lin, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:12

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  22. Content type: Research article

    Computational, genome based predictions of organism phenotypes has enhanced the ability to investigate the biological phenomena that help organisms survive and respond to their environments. In this study, we ...

    Authors: Joseph J. Gardner and Nanette R. Boyle

    Citation: BMC Systems Biology 2017 11:4

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  23. Content type: Research Article

    As metabolic pathway resources become more commonly available, researchers have unprecedented access to information about their organism of interest. Despite efforts to ensure consistency between various resou...

    Authors: Jesse R. Walsh, Mary L. Schaeffer, Peifen Zhang, Seung Y. Rhee, Julie A. Dickerson and Taner Z. Sen

    Citation: BMC Systems Biology 2016 10:129

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  24. Content type: Research article

    Corynebacterium pseudotuberculosis (Cp) is a gram-positive bacterium that is classified into equi and ovis serovars. The serovar ovis is the etiological agent of caseous lymphadenitis,...

    Authors: Edson Luiz Folador, Paulo Vinícius Sanches Daltro de Carvalho, Wanderson Marques Silva, Rafaela Salgado Ferreira, Artur Silva, Michael Gromiha, Preetam Ghosh, Debmalya Barh, Vasco Azevedo and Richard Röttger

    Citation: BMC Systems Biology 2016 10:103

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  25. Content type: Research article

    During the last decades, we face an increasing interest in superior plants to supply growing demands for human and animal nutrition and for the developing bio-based economy. Presently, our limited understandin...

    Authors: Veronique Beckers, Lisa Maria Dersch, Katrin Lotz, Guido Melzer, Oliver Ernst Bläsing, Regine Fuchs, Thomas Ehrhardt and Christoph Wittmann

    Citation: BMC Systems Biology 2016 10:102

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  26. Content type: Research article

    The complex interplay between viral replication and host immune response during infection remains poorly understood. While many viruses are known to employ anti-immune strategies to facilitate their replicatio...

    Authors: Jason E. McDermott, Hugh D. Mitchell, Lisa E. Gralinski, Amie J. Eisfeld, Laurence Josset, Armand Bankhead III, Gabriele Neumann, Susan C. Tilton, Alexandra Schäfer, Chengjun Li, Shufang Fan, Shannon McWeeney, Ralph S. Baric, Michael G. Katze and Katrina M. Waters

    Citation: BMC Systems Biology 2016 10:93

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  27. Content type: Research Article

    Identifying the gene regulatory networks governing the workings and identity of cells is one of the main challenges in understanding processes such as cellular differentiation, reprogramming or cancerogenesis....

    Authors: Maryam Nazarieh, Andreas Wiese, Thorsten Will, Mohamed Hamed and Volkhard Helms

    Citation: BMC Systems Biology 2016 10:88

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  28. Content type: Research article

    Phytohormone synergies and signaling interdependency are important topics in plant developmental biology. Physiological and genetic experimental evidence for phytohormone crosstalk has been accumulating and a ...

    Authors: Xun Yue, Xing Guo Li, Xin-Qi Gao, Xiang Yu Zhao, Yu Xiu Dong and Chao Zhou

    Citation: BMC Systems Biology 2016 10:87

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  29. Content type: Research Article

    Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role ...

    Authors: Simona Catozzi, Juan Pablo Di-Bella, Alejandra C. Ventura and Jacques-Alexandre Sepulchre

    Citation: BMC Systems Biology 2016 10:84

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  30. Content type: Research article

    Glioma differentiation therapy is a novel strategy that has been used to induce glioma cells to differentiate into glia-like cells. Although some advances in experimental methods for exploring the molecular me...

    Authors: Xiaoqiang Sun, Jiajun Zhang, Qi Zhao, Xing Chen, Wenbo Zhu, Guangmei Yan and Tianshou Zhou

    Citation: BMC Systems Biology 2016 10:73

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  31. Content type: Research article

    It has been found that microRNAs (miRNAs) can function as a regulatory factor across species. For example, food-derived plant miRNAs may pass through the gastrointestinal (GI) tract, enter into the plasma and ...

    Authors: Hao Zhang, Yanpu Li, Yuanning Liu, Haiming Liu, Hongyu Wang, Wen Jin, Yanmei Zhang, Chao Zhang and Dong Xu

    Citation: BMC Systems Biology 2016 10:60

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  32. Content type: Research article

    The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often address...

    Authors: Bin Du, Daniel C. Zielinski, Erol S. Kavvas, Andreas Dräger, Justin Tan, Zhen Zhang, Kayla E. Ruggiero, Garri A. Arzumanyan and Bernhard O. Palsson

    Citation: BMC Systems Biology 2016 10:40

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  33. Content type: Research Article

    Budding yeast, S. cerevisiae, has been used extensively as a model organism for studying cellular processes in evolutionarily distant species, including humans. However, different human tissues, while inheriti...

    Authors: Shahin Mohammadi, Baharak Saberidokht, Shankar Subramaniam and Ananth Grama

    Citation: BMC Systems Biology 2015 9:96

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2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)


    Social Media Impact
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