Skip to content


Networks and information flow

Page 1 of 9
  1. Content type: Research article

    For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) with...

    Authors: Alessandra Ordinelli, Nicola Bernabò, Massimiliano Orsini, Mauro Mattioli and Barbara Barboni

    Citation: BMC Systems Biology 2018 12:52

    Published on:

  2. Content type: Research article

    Controlling complex molecular regulatory networks is getting a growing attention as it can provide a systematic way of driving any cellular state to a desired cell phenotypic state. A number of recent studies ...

    Authors: Sang-Mok Choo, Byunghyun Ban, Jae Il Joo and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2018 12:49

    Published on:

  3. Content type: Methodology Article

    Many mathematical models have now been employed across every area of systems biology. These models increasingly involve large numbers of unknown parameters, have complex structure which can result in substanti...

    Authors: Ian Vernon, Junli Liu, Michael Goldstein, James Rowe, Jen Topping and Keith Lindsey

    Citation: BMC Systems Biology 2018 12:1

    Published on:

  4. Content type: Research Article

    Cellular behaviors are governed by interaction networks among biomolecules, for example gene regulatory and signal transduction networks. An often used dynamic modeling framework for these networks, Boolean mo...

    Authors: Parul Maheshwari and Réka Albert

    Citation: BMC Systems Biology 2017 11:122

    Published on:

  5. Content type: Research Article

    Biochemical oscillations play an important role in maintaining physiological and cellular homeostasis in biological systems. The frequency and amplitude of oscillations are regulated to properly adapt to envir...

    Authors: Jun Hyuk Kang and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:95

    Published on:

  6. Content type: Methodology Article

    Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they f...

    Authors: Leonie Amstein, Jörg Ackermann, Jennifer Scheidel, Simone Fulda, Ivan Dikic and Ina Koch

    Citation: BMC Systems Biology 2017 11:72

    Published on:

  7. Content type: Research article

    Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-...

    Authors: Mariana E. Martinez-Sanchez, Marcia Hiriart and Elena R. Alvarez-Buylla

    Citation: BMC Systems Biology 2017 11:64

    Published on:

  8. Content type: Research Article

    The human gut contains approximately 1014 bacteria, belonging to hundreds of different species. Together, these microbial species form a complex food web that can break down nutrient sources that our own digestiv...

    Authors: Milan J. A. van Hoek and Roeland M. H. Merks

    Citation: BMC Systems Biology 2017 11:56

    Published on:

  9. Content type: Database

    Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction i...

    Authors: Abraham A. Labena, Yuan-Nong Ye, Chuan Dong, Fa-Z Zhang and Feng-Biao Guo

    Citation: BMC Systems Biology 2017 11:50

    Published on:

  10. Content type: Research Article

    Cancer reversion, converting the phenotypes of a cancer cell into those of a normal cell, has been sporadically observed throughout history. However, no systematic analysis has been attempted so far.

    Authors: Yunseong Kim, Sea Choi, Dongkwan Shin and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2017 11:45

    Published on:

  11. Content type: Research article

    Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments. The elucidation of the cell biolo...

    Authors: Anne Mathilde Lund, Christian Schrøder Kaas, Julian Brandl, Lasse Ebdrup Pedersen, Helene Faustrup Kildegaard, Claus Kristensen and Mikael Rørdam Andersen

    Citation: BMC Systems Biology 2017 11:37

    Published on:

  12. Content type: Research article

    Gain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysm...

    Authors: Dimos Kapetis, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N. Xenakis, Ronald L. Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G. Faber, Monique Gerrits, Ingemar S. J. Merkies, Sulayman D. Dib-Hajj, Massimo Mantegazza, Stephen G. Waxman and Giuseppe Lauria

    Citation: BMC Systems Biology 2017 11:28

    Published on:

  13. Content type: Research article

    Physical and functional interplays between genes or proteins have important biological meaning for cellular functions. Some efforts have been made to construct weighted gene association meta-networks by integr...

    Authors: Jian Yang, Tinghong Yang, Duzhi Wu, Limei Lin, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:12

    Published on:

  14. Content type: Research article

    Computational, genome based predictions of organism phenotypes has enhanced the ability to investigate the biological phenomena that help organisms survive and respond to their environments. In this study, we ...

    Authors: Joseph J. Gardner and Nanette R. Boyle

    Citation: BMC Systems Biology 2017 11:4

    Published on:

  15. Content type: Research Article

    As metabolic pathway resources become more commonly available, researchers have unprecedented access to information about their organism of interest. Despite efforts to ensure consistency between various resou...

    Authors: Jesse R. Walsh, Mary L. Schaeffer, Peifen Zhang, Seung Y. Rhee, Julie A. Dickerson and Taner Z. Sen

    Citation: BMC Systems Biology 2016 10:129

    Published on:

  16. Content type: Research article

    Corynebacterium pseudotuberculosis (Cp) is a gram-positive bacterium that is classified into equi and ovis serovars. The serovar ovis is the etiological agent of caseous lymphadenitis,...

    Authors: Edson Luiz Folador, Paulo Vinícius Sanches Daltro de Carvalho, Wanderson Marques Silva, Rafaela Salgado Ferreira, Artur Silva, Michael Gromiha, Preetam Ghosh, Debmalya Barh, Vasco Azevedo and Richard Röttger

    Citation: BMC Systems Biology 2016 10:103

    Published on:

Page 1 of 9

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    1233 Usage Factor

    Social Media Impact
    134 mentions