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Synthetic biology

Section edited by Sang Yup Lee

This section covers the application of systems biology, biotechnology and an engineering approach to the design and construction of novel biological functions, and in particular those with industrial or biomedical importance.

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  1. Content type: Research article

    Actinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess ...

    Authors: Bruno Pereira, Joana Miguel, Paulo Vilaça, Simão Soares, Isabel Rocha and Sónia Carneiro

    Citation: BMC Systems Biology 2018 12:61

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  2. Content type: Methodology Article

    State-of-the-art strain engineering techniques for the host Pichia pastoris (syn. Komagataella spp.) include overexpression of homologous and heterologous genes, and deletion of host genes. For metabolic and cell...

    Authors: Roland Prielhofer, Juan J. Barrero, Stefanie Steuer, Thomas Gassler, Richard Zahrl, Kristin Baumann, Michael Sauer, Diethard Mattanovich, Brigitte Gasser and Hans Marx

    Citation: BMC Systems Biology 2017 11:123

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  3. Content type: Research Article

    In favorable conditions bacterial doubling time is less than 20 min, shorter than DNA replication time. In E. coli a single round of genome replication lasts about 40 min and it must be accomplished about 20 min ...

    Authors: Joanna Jaruszewicz-Błońska and Tomasz Lipniacki

    Citation: BMC Systems Biology 2017 11:117

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  4. Content type: Research Article

    Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga which has become a biotechnological target because of its high capacity to produce polyunsaturated fatty acids and tr...

    Authors: Nicolás Loira, Sebastian Mendoza, María Paz Cortés, Natalia Rojas, Dante Travisany, Alex Di Genova, Natalia Gajardo, Nicole Ehrenfeld and Alejandro Maass

    Citation: BMC Systems Biology 2017 11:66

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  5. Content type: Research Article

    The increase in glycerol obtained as a byproduct of biodiesel has encouraged the production of new industrial products, such as 1,3-propanediol (PDO), using biotechnological transformation via bacteria like Clost...

    Authors: Luis Miguel Serrano-Bermúdez, Andrés Fernando González Barrios, Costas D. Maranas and Dolly Montoya

    Citation: BMC Systems Biology 2017 11:58

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  6. Content type: Research Article

    Genetic switches exhibit multistability, form the basis of epigenetic memory, and are found in natural decision making systems, such as cell fate determination in developmental pathways. Synthetic genetic swit...

    Authors: Miriam Leon, Mae L. Woods, Alex J. H. Fedorec and Chris P. Barnes

    Citation: BMC Systems Biology 2016 10:130

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  7. Content type: Research article

    A complex network of gene interactions controls gene regulation throughout development and the life of the organisms. Insights can be made into these processes by studying the functional interactions (or “moti...

    Authors: Ashley A. Jermusyk, Nicholas P. Murphy and Gregory T. Reeves

    Citation: BMC Systems Biology 2016 10:85

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  8. Content type: Research Article

    Genetic switches are ubiquitous in nature, frequently associated with the control of cellular functions and developmental programs. In the realm of synthetic biology, it is of great interest to engineer geneti...

    Authors: Nikolay Martyushenko, Sigurd Hagen Johansen, Cheol-Min Ghim and Eivind Almaas

    Citation: BMC Systems Biology 2016 10:39

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  9. Content type: Research Article

    Model based design plays a fundamental role in synthetic biology. Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key...

    Authors: Yadira Boada, Gilberto Reynoso-Meza, Jesús Picó and Alejandro Vignoni

    Citation: BMC Systems Biology 2016 10:27

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  10. Content type: Research article

    Multicellular organisms depend on the exchange of information between specialized cells. This communication is often difficult to decipher in its native context, but synthetic biology provides tools to enginee...

    Authors: Katja Kolar, Hanna M. Wischhusen, Konrad Müller, Maria Karlsson, Wilfried Weber and Matias D. Zurbriggen

    Citation: BMC Systems Biology 2015 9:97

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  11. Content type: Research article

    The gene expression and secretion of fungal lignocellulolytic enzymes are tightly controlled at the transcription level using independent mechanisms to respond to distinct inducers from plant biomass. An advan...

    Authors: D.B.R.K. Gupta Udatha, Evangelos Topakas, Margarita Salazar, Lisbeth Olsson, Mikael R. Andersen and Gianni Panagiotou

    Citation: BMC Systems Biology 2015 9:77

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  12. Content type: Research article

    Rhodococcus jostii RHA1 growing on different substrates is capable of accumulating simultaneously three types of carbon storage compounds: glycogen, polyhydroxyalkanoates (PHA), and tr...

    Authors: Mohammad Tajparast and Dominic Frigon

    Citation: BMC Systems Biology 2015 9:43

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  13. Content type: Research article

    Understanding how cells make decisions, and why they make the decisions they make, is of fundamental interest in systems biology. To address this, we study the decisions made by E. coli on which genes to express ...

    Authors: Guy Aidelberg, Benjamin D Towbin, Daphna Rothschild, Erez Dekel, Anat Bren and Uri Alon

    Citation: BMC Systems Biology 2014 8:133

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  14. Content type: Research article

    Regulated proteolysis by the proteasome is one of the fundamental mechanisms used in eukaryotic cells to control cellular behavior. Efficient tools to regulate protein stability offer synthetic influence on mo...

    Authors: Svetlana Usherenko, Hilke Stibbe, Massimiliano Muscó, Lars-Oliver Essen, Ekaterina A Kostina and Christof Taxis

    Citation: BMC Systems Biology 2014 8:128

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  15. Content type: Methodology Article

    One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple...

    Authors: Irene Otero-Muras and Julio R Banga

    Citation: BMC Systems Biology 2014 8:113

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  16. Content type: Research article

    In photosynthetic organisms, the influence of light, carbon and inorganic nitrogen sources on the cellular bioenergetics has extensively been studied independently, but little information is available on the c...

    Authors: Stéphanie Gérin, Grégory Mathy and Fabrice Franck

    Citation: BMC Systems Biology 2014 8:96

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  17. Content type: Research article

    Thermobifida fusca is a cellulolytic bacterium with potential to be used as a platform organism for sustainable industrial production of biofuels, pharmaceutical ingredients and other bioprocesses due to its cap...

    Authors: Niti Vanee, J Paul Brooks, Victor Spicer, Dmitriy Shamshurin, Oleg Krokhin, John A Wilkins, Yu Deng and Stephen S Fong

    Citation: BMC Systems Biology 2014 8:86

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2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    1233 Usage Factor

    Social Media Impact
    134 mentions