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  1. Content type: Research article

    The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimetho...

    Authors: Guan-Sheng Liu, Richard Ballweg, Alan Ashbaugh, Yin Zhang, Joseph Facciolo, Melanie T. Cushion and Tongli Zhang

    Citation: BMC Systems Biology 2018 12:77

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  2. Content type: Research article

    The hypothalamic-pituitary-adrenal (HPA) axis is a central regulator of stress response and its dysfunction has been associated with a broad range of complex illnesses including Gulf War Illness (GWI) and Chro...

    Authors: Hooman Sedghamiz, Matthew Morris, Travis J. A. Craddock, Darrell Whitley and Gordon Broderick

    Citation: BMC Systems Biology 2018 12:76

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  3. Content type: Research article

    The effort to characterize intrinsically disordered regions of signaling proteins is rapidly expanding. An important class of disordered interaction modules are ubiquitous and functionally diverse elements kno...

    Authors: Bob Strome, Ian Shenyen Hsu, Mitchell Li Cheong Man, Taraneh Zarin, Alex Nguyen Ba and Alan M. Moses

    Citation: BMC Systems Biology 2018 12:75

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  4. Content type: Research article

    Reaction gap filling is a computational technique for proposing the addition of reactions to genome-scale metabolic models to permit those models to run correctly. Gap filling completes what are otherwise inco...

    Authors: Peter D. Karp, Daniel Weaver and Mario Latendresse

    Citation: BMC Systems Biology 2018 12:73

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  5. Content type: Software

    One of the major challenges in traditional mathematical modeling of gene regulatory circuits is the insufficient knowledge of kinetic parameters. These parameters are often inferred from existing experimental ...

    Authors: Bin Huang, Dongya Jia, Jingchen Feng, Herbert Levine, José N. Onuchic and Mingyang Lu

    Citation: BMC Systems Biology 2018 12:74

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  6. Content type: Software

    Models of metabolism are often used in biotechnology and pharmaceutical research to identify drug targets or increase the direct production of valuable compounds. Due to the complexity of large metabolic syste...

    Authors: Robert W. Smith, Rik P. van Rosmalen, Vitor A. P. Martins dos Santos and Christian Fleck

    Citation: BMC Systems Biology 2018 12:72

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  7. Content type: Research article

    Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between...

    Authors: Rosa D. Hernansaiz-Ballesteros, Luca Cardelli and Attila Csikász-Nagy

    Citation: BMC Systems Biology 2018 12:70

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  8. Content type: Methodology article

    A novel framework is proposed to analyse metabolic fluxes in non-steady state conditions, based on the new concept of dynamic elementary mode (dynEM): an elementary mode activated partially depending on the ti...

    Authors: Abel Folch-Fortuny, Bas Teusink, Huub C.J. Hoefsloot, Age K. Smilde and Alberto Ferrer

    Citation: BMC Systems Biology 2018 12:71

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  9. Content type: Methodology article

    Understanding the dynamical behaviour of biological systems is challenged by their large number of components and interactions. While efforts have been made in this direction to reduce model complexity, they o...

    Authors: Stefano Casagranda, Suzanne Touzeau, Delphine Ropers and Jean-Luc Gouzé

    Citation: BMC Systems Biology 2018 12:68

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  10. Content type: Research article

    Escherichia coli is considered a leading bacterial trigger of inflammatory bowel disease (IBD). E. coli isolates from IBD patients primarily belong to phylogroup B2. Previous studies have focused on broad compara...

    Authors: Xin Fang, Jonathan M. Monk, Nathan Mih, Bin Du, Anand V. Sastry, Erol Kavvas, Yara Seif, Larry Smarr and Bernhard O. Palsson

    Citation: BMC Systems Biology 2018 12:66

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  11. Content type: Methodology article

    Certain biological processes, such as the development of cancer and immune activation, can be controlled by rare cellular events that are difficult to capture computationally through simulations of individual ...

    Authors: Brian C. Ross, Mayla Boguslav, Holly Weeks and James C. Costello

    Citation: BMC Systems Biology 2018 12:64

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  12. Content type: Methodology article

    Metabolic reactions are chemical transformations commonly catalyzed by enzymes. In recent years, the explosion of genomic data and individual experimental characterizations have contributed to the construction...

    Authors: Carlos Vazquez-Hernandez, Antonio Loza, Esteban Peguero-Sanchez, Lorenzo Segovia and Rosa-Maria Gutierrez-Rios

    Citation: BMC Systems Biology 2018 12:63

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  13. Content type: Research article

    Actinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess ...

    Authors: Bruno Pereira, Joana Miguel, Paulo Vilaça, Simão Soares, Isabel Rocha and Sónia Carneiro

    Citation: BMC Systems Biology 2018 12:61

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  14. Content type: Regular article

    Atrial fibrillation is a cardiac disease driven by numerous idiopathic etiologies. NUP155 is a nuclear pore complex protein that has been identified as a clinical driver of atrial fibrillation, yet the precise...

    Authors: Claudia C. Preston, Saranya P. Wyles, Santiago Reyes, Emily C. Storm, Bruce W. Eckloff and Randolph S. Faustino

    Citation: BMC Systems Biology 2018 12:62

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  15. Content type: Research Article

    Multilevel data integration is becoming a major area of research in systems biology. Within this area, multi-‘omics datasets on complex diseases are becoming more readily available and there is a need to set s...

    Authors: Bertrand De Meulder, Diane Lefaudeux, Aruna T. Bansal, Alexander Mazein, Amphun Chaiboonchoe, Hassan Ahmed, Irina Balaur, Mansoor Saqi, Johann Pellet, Stéphane Ballereau, Nathanaël Lemonnier, Kai Sun, Ioannis Pandis, Xian Yang, Manohara Batuwitage, Kosmas Kretsos…

    Citation: BMC Systems Biology 2018 12:60

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  16. Content type: Software

    Reconstruction of executable mechanistic models from single-cell gene expression data represents a powerful approach to understanding developmental and disease processes. New ambitious efforts like the Human C...

    Authors: Steven Woodhouse, Nir Piterman, Christoph M. Wintersteiger, Berthold Göttgens and Jasmin Fisher

    Citation: BMC Systems Biology 2018 12:59

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  17. Content type: Review

    Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance...

    Authors: Frank Kramer, Steffen Just and Tanja Zeller

    Citation: BMC Systems Biology 2018 12:57

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  18. Content type: Research

    The human body is colonized by a vast number of microbes. Microbiota can benefit many normal life processes, but can also cause many diseases by interfering the regular metabolism and immune system. Recent stu...

    Authors: Jialu Hu, Yiqun Gao, Yan Zheng and Xuequn Shang

    Citation: BMC Systems Biology 2018 12(Suppl 4):54

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    This article is part of a Supplement: Volume 12 Supplement 4

  19. Content type: Research

    The haematopoietic lineages with leukaemia lineages are considered in this paper. In particular, we mainly consider that haematopoietic lineages are tightly controlled by negative feedback inhibition of end-pr...

    Authors: Jianfeng Jiao, Min Luo and Ruiqi Wang

    Citation: BMC Systems Biology 2018 12(Suppl 4):43

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  20. Content type: Research

    Efficient computational recognition and segmentation of target organ from medical images are foundational in diagnosis and treatment, especially about pancreas cancer. In practice, the diversity in appearance ...

    Authors: Min Fu, Wenming Wu, Xiafei Hong, Qiuhua Liu, Jialin Jiang, Yaobin Ou, Yupei Zhao and Xinqi Gong

    Citation: BMC Systems Biology 2018 12(Suppl 4):56

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

Page 1 of 78

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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