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  1. Content type: Research

    Protein post-translational modification (PTM) plays an essential role in various cellular processes that modulates the physical and chemical properties, folding, conformation, stability and activity of protein...

    Authors: Min-Gang Su, Julia Tzu-Ya Weng, Justin Bo-Kai Hsu, Kai-Yao Huang, Yu-Hsiang Chi and Tzong-Yi Lee

    Citation: BMC Systems Biology 2017 11(Suppl 7):132

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  2. Content type: Research

    Rheumatism represents any disease condition marked with inflammation and pain in the joints, muscles, or connective tissues. Many traditional Chinese drugs have been used for a long time to treat rheumatism. H...

    Authors: Qingping Liu, Jiahao Wang, Yan Zhu and Yongqun He

    Citation: BMC Systems Biology 2017 11(Suppl 7):130

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  3. Content type: Research

    Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of ...

    Authors: Huipeng Li, Lakshmi Venkatraman, Balakrishnan Chakrapani Narmada, Jacob K. White, Hanry Yu and Lisa Tucker-Kellogg

    Citation: BMC Systems Biology 2017 11(Suppl 7):136

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  4. Content type: Research

    Anti-microbial peptides (AMPs), naturally encoded by genes and generally containing 12–100 amino acids, are crucial components of the innate immune system and can protect the host from various pathogenic bacte...

    Authors: Kai-Yao Huang, Tzu-Hao Chang, Jhih-Hua Jhong, Yu-Hsiang Chi, Wen-Chi Li, Chien-Lung Chan, K. Robert Lai and Tzong-Yi Lee

    Citation: BMC Systems Biology 2017 11(Suppl 7):131

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  5. Content type: Software

    We propose OptPipe - a Pipeline for Optimizing Metabolic Engineering Targets, based on a consensus approach. The method generates consensus hypotheses for metabolic engineering applications by combining severa...

    Authors: András Hartmann, Ana Vila-Santa, Nicolai Kallscheuer, Michael Vogt, Alice Julien-Laferrière, Marie-France Sagot, Jan Marienhagen and Susana Vinga

    Citation: BMC Systems Biology 2017 11:143

    Published on:

  6. Content type: Research

    Biological networks consisting of molecular components and interactions are represented by a graph model. There have been some studies based on that model to analyze a relationship between structural character...

    Authors: Cong-Doan Truong and Yung-Keun Kwon

    Citation: BMC Systems Biology 2017 11(Suppl 7):125

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  7. Content type: Research

    Cell fate regulation directly affects tissue homeostasis and human health. Research on cell fate decision sheds light on key regulators, facilitates understanding the mechanisms, and suggests novel strategies ...

    Authors: Lichun Ma and Jie Zheng

    Citation: BMC Systems Biology 2017 11(Suppl 7):126

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  8. Content type: Research

    Breast cancer is one of the leading causes of deaths for women. It is of great necessity to develop effective methods for breast cancer detection and diagnosis. Recent studies have focused on gene-based signat...

    Authors: Hao Jiang, Wai-Ki Ching, Wai-Shun Cheung, Wenpin Hou and Hong Yin

    Citation: BMC Systems Biology 2017 11(Suppl 7):138

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  9. Content type: Research

    Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is r...

    Authors: Hui-Ju Kao, Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Justin Bo-Kai Hsu, Chien-Hsun Huang and Tzong-Yi Lee

    Citation: BMC Systems Biology 2017 11(Suppl 7):137

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 7

  10. Content type: Review

    Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural ...

    Authors: Massimo S. Fiandaca, Mark Mapstone, Elenora Connors, Mireille Jacobson, Edwin S. Monuki, Shaista Malik, Fabio Macciardi and Howard J. Federoff

    Citation: BMC Systems Biology 2017 11:142

    Published on:

  11. Content type: Research Article

    Estrogen is a vital hormone that regulates many biological functions within the body. These include roles in the development of the secondary sexual organs in both sexes, plus uterine angiogenesis and prolifer...

    Authors: Joanna H. Sier, Alfred E. Thumser and Nick J. Plant

    Citation: BMC Systems Biology 2017 11:141

    Published on:

  12. Content type: Methodology

    Positive semi-definiteness is a critical property in kernel methods for Support Vector Machine (SVM) by which efficient solutions can be guaranteed through convex quadratic programming. However, a lot of simil...

    Authors: Hao Jiang, Wai-Ki Ching, Yushan Qiu and Xiao-Qing Cheng

    Citation: BMC Systems Biology 2017 11(Suppl 6):115

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  13. Content type: Research

    Traditional drug identification methods follow the “one drug-one target” thought. But those methods ignore the natural characters of human diseases. To overcome this limitation, many identification methods of ...

    Authors: Jin-Xing Liu, Dong-Qin Wang, Chun-Hou Zheng, Ying-Lian Gao, Sha-Sha Wu and Jun-Liang Shang

    Citation: BMC Systems Biology 2017 11(Suppl 6):119

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  14. Content type: Research

    Mining frequent gene regulation sequential patterns in time course microarray datasets is an important mining task in bioinformatics. Although finding such patterns are of paramount important for studying a di...

    Authors: Morteza Zihayat, Heidar Davoudi and Aijun An

    Citation: BMC Systems Biology 2017 11(Suppl 6):109

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  15. Content type: Research

    Drug side effects are one of main concerns in the drug discovery, which gains wide attentions. Investigating drug side effects is of great importance, and the computational prediction can help to guide wet exp...

    Authors: Wen Zhang, Xiang Yue, Feng Liu, Yanlin Chen, Shikui Tu and Xining Zhang

    Citation: BMC Systems Biology 2017 11(Suppl 6):101

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  16. Content type: Methodology

    Probabilistic Boolean networks (PBNs) have been proposed for analyzing external control in gene regulatory networks with incorporation of uncertainty. A context-sensitive PBN with perturbation (CS-PBNp), exten...

    Authors: Ou Wei, Zonghao Guo, Yun Niu and Wenyuan Liao

    Citation: BMC Systems Biology 2017 11(Suppl 6):104

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  17. Content type: Research

    Building the evolutionary trees for massive unaligned DNA sequences is challenging and crucial. However, reconstructing evolutionary tree for ultra-large sequences is hard. Massive multiple sequence alignment ...

    Authors: Quan Zou, Shixiang Wan, Xiangxiang Zeng and Zhanshan Sam Ma

    Citation: BMC Systems Biology 2017 11(Suppl 6):100

    Published on:

    This article is part of a Supplement: Volume 11 Supplement 6

  18. Content type: Research Article

    Specific cellular states are often associated with distinct gene expression patterns. These states are plastic, changing during development, or in the transition from health to disease. One relatively simple e...

    Authors: Daniel Schlauch, Kimberly Glass, Craig P. Hersh, Edwin K. Silverman and John Quackenbush

    Citation: BMC Systems Biology 2017 11:139

    Published on:

  19. Content type: Methodology Article

    Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tiss...

    Authors: Justin Caccavale, David Fiumara, Michael Stapf, Liedeke Sweitzer, Hannah J. Anderson, Jonathan Gorky, Prasad Dhurjati and Deni S. Galileo

    Citation: BMC Systems Biology 2017 11:124

    Published on:

  20. Content type: Methodology Article

    State-of-the-art strain engineering techniques for the host Pichia pastoris (syn. Komagataella spp.) include overexpression of homologous and heterologous genes, and deletion of host genes. For metabolic and cell...

    Authors: Roland Prielhofer, Juan J. Barrero, Stefanie Steuer, Thomas Gassler, Richard Zahrl, Kristin Baumann, Michael Sauer, Diethard Mattanovich, Brigitte Gasser and Hans Marx

    Citation: BMC Systems Biology 2017 11:123

    Published on:

  21. Content type: Research Article

    Cellular behaviors are governed by interaction networks among biomolecules, for example gene regulatory and signal transduction networks. An often used dynamic modeling framework for these networks, Boolean mo...

    Authors: Parul Maheshwari and Réka Albert

    Citation: BMC Systems Biology 2017 11:122

    Published on:

  22. Content type: Research Article

    Polygenic diseases are usually caused by the dysfunction of multiple genes. Unravelling such disease genes is crucial to fully understand the genetic landscape of diseases on molecular level. With the advent o...

    Authors: Limei Lin, Tinghong Yang, Ling Fang, Jian Yang, Fan Yang and Jing Zhao

    Citation: BMC Systems Biology 2017 11:121

    Published on:

Page 3 of 77

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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