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  1. Content type: Research article

    Existing experimental data have shown hypoxia to be an important factor affecting the proliferation of mesenchymal stromal cells (MSCs), but the contrasting observations made at various hypoxic levels raise th...

    Authors: Bo Zhang, Hua Ye and Aidong Yang

    Citation: BMC Systems Biology 2018 12:35

    Published on:

  2. Content type: Research article

    Melanoma can be diagnosed by identifying nests of cells on the skin surface. Understanding the processes that drive nest formation is important as these processes could be potential targets for new cancer drug...

    Authors: Parvathi Haridas, Alexander P. Browning, Jacqui A. McGovern, D. L. Sean McElwain and Matthew J. Simpson

    Citation: BMC Systems Biology 2018 12:34

    Published on:

  3. Content type: Research

    The integration of gene expression profiles (GEPs) and large-scale biological networks derived from pathways databases is a subject which is being widely explored. Existing methods are based on network distanc...

    Authors: Bertrand Miannay, Stéphane Minvielle, Florence Magrangeas and Carito Guziolowski

    Citation: BMC Systems Biology 2018 12(Suppl 3):32

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  4. Content type: Research

    Expression-based phenotype classification using either microarray or RNA-Seq measurements suffers from a lack of specificity because pathway timing is not revealed and expressions are averaged across groups of...

    Authors: Alireza Karbalayghareh, Ulisses Braga-Neto and Edward R. Dougherty

    Citation: BMC Systems Biology 2018 12(Suppl 3):23

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  5. Content type: Research

    Decomposing a protein-protein interaction network (PPI network) into non-overlapping clusters or communities, sometimes called “network modules,” is an important way to explore functional roles of sets of gene...

    Authors: Sarah Hall-Swan, Jake Crawford, Rebecca Newman and Lenore J. Cowen

    Citation: BMC Systems Biology 2018 12(Suppl 3):24

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  6. Content type: Software

    The 16S rRNA gene-based amplicon sequencing analysis is widely used to determine the taxonomic composition of microbial communities. Once the taxonomic composition of each community is obtained, evolutionary r...

    Authors: Hiroshi Mori, Takayuki Maruyama, Masahiro Yano, Takuji Yamada and Ken Kurokawa

    Citation: BMC Systems Biology 2018 12(Suppl 2):30

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  7. Content type: Research

    Transcriptomic datasets often contain undeclared heterogeneity arising from biological variation such as diversity of disease subtypes, treatment subgroups, time-series gene expression, nested experimental con...

    Authors: Abha Belorkar, Rajanikanth Vadigepalli and Limsoon Wong

    Citation: BMC Systems Biology 2018 12(Suppl 2):28

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  8. Content type: Research

    Recently, there have been several attempts to produce long-chain dicarboxylic acids (DCAs) in various microbial hosts. Of these, Yarrowia lipolytica has great potential due to its oleaginous characteristics and u...

    Authors: Pranjul Mishra, Na-Rae Lee, Meiyappan Lakshmanan, Minsuk Kim, Byung-Gee Kim and Dong-Yup Lee

    Citation: BMC Systems Biology 2018 12(Suppl 2):12

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  9. Content type: Research

    Identifying gene regulatory networks is an important task for understanding biological systems. Time-course measurement data became a valuable resource for inferring gene regulatory networks. Various methods h...

    Authors: Sungjoon Park, Jung Min Kim, Wonho Shin, Sung Won Han, Minji Jeon, Hyun Jin Jang, Ik-Soon Jang and Jaewoo Kang

    Citation: BMC Systems Biology 2018 12(Suppl 2):20

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  10. Content type: Research

    Regeneration is an important biological process for the restoration of organ mass, structure, and function after damage, and involves complex bio-physiological mechanisms including cell differentiation and imm...

    Authors: Fang-Yu Liu, Te-Cheng Hsu, Patrick Choong, Min-Hsuan Lin, Yung-Jen Chuang, Bor-Sen Chen and Che Lin

    Citation: BMC Systems Biology 2018 12(Suppl 2):29

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  11. Content type: Research

    One of the crucial steps toward understanding the associations among molecular interactions, pathways, and diseases in a cell is to investigate detailed atomic protein-protein interactions (PPIs) in the struct...

    Authors: Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yu-Yao Tseng and Jinn-Moon Yang

    Citation: BMC Systems Biology 2018 12(Suppl 2):13

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  12. Content type: Research

    Ginseng is a popular traditional herbal medicine in north-eastern Asia. It has been used for human health for over thousands of years. With the rise in global temperature, the production of Korean ginseng (Pan...

    Authors: Inuk Jung, Hyejin Kang, Jang Uk Kim, Hyeonsook Chang, Sun Kim and Woosuk Jung

    Citation: BMC Systems Biology 2018 12(Suppl 2):27

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  13. Content type: Research

    With the rapid advancement of array-based genotyping techniques, genome-wide association studies (GWAS) have successfully identified common genetic variants associated with common complex diseases. However, it...

    Authors: Minseok Kwon, Sangseob Leem, Joon Yoon and Taesung Park

    Citation: BMC Systems Biology 2018 12(Suppl 2):19

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  14. Content type: Research

    Cell surface proteins have provided useful targets and biomarkers for advanced cancer therapies. The recent clinical success of antibody-drug conjugates (ADCs) highlights the importance of finding selective su...

    Authors: Yourae Hong, Choa Park, Nayoung Kim, Juyeon Cho, Sung Ung Moon, Jongmin Kim, Euna Jeong and Sukjoon Yoon

    Citation: BMC Systems Biology 2018 12(Suppl 2):17

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  15. Content type: Research

    Drug combination therapy, which is considered as an alternative to single drug therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug combination therapies are widely u...

    Authors: Minji Jeon, Sunkyu Kim, Sungjoon Park, Heewon Lee and Jaewoo Kang

    Citation: BMC Systems Biology 2018 12(Suppl 2):16

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  16. Content type: Research

    Gene Ontology (GO) is one of the most popular bioinformatics resources. In the past decade, Gene Ontology-based gene semantic similarity has been effectively used to model gene-to-gene interactions in multiple...

    Authors: Jiajie Peng, Xuanshuo Zhang, Weiwei Hui, Junya Lu, Qianqian Li, Shuhui Liu and Xuequn Shang

    Citation: BMC Systems Biology 2018 12(Suppl 2):18

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 2

  17. Content type: Review Article

    Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “o...

    Authors: James T. Yurkovich, Aarash Bordbar, Ólafur E. Sigurjónsson and Bernhard O. Palsson

    Citation: BMC Systems Biology 2018 12:31

    Published on:

  18. Content type: Research Article

    Muscle atrophy, an involuntary loss of muscle mass, is involved in various diseases and sometimes leads to mortality. However, therapeutics for muscle atrophy thus far have had limited effects. Here, we presen...

    Authors: Jinmyung Jung, Mijin Kwon, Sunghwa Bae, Soorin Yim and Doheon Lee

    Citation: BMC Systems Biology 2018 12:26

    Published on:

  19. Content type: Research Article

    The efficacy of antibiotics against M. tuberculosis has been shown to be influenced by experimental media conditions. Investigations of M. tuberculosis growth in physiological conditions have described an environ...

    Authors: Erol S. Kavvas, Yara Seif, James T. Yurkovich, Charles Norsigian, Saugat Poudel, William W. Greenwald, Sankha Ghatak, Bernhard O. Palsson and Jonathan M. Monk

    Citation: BMC Systems Biology 2018 12:25

    Published on:

  20. Content type: Correction

    After publication of the article [1], it has been brought to our attention that an author’s name was spelt incorrectly in the original published article. Yonghua Wang was previously spelt “Yonghua Wan”. This h...

    Authors: Mohamed Shahen, Zihu Guo, Akhtar Hussain Shar, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao and Yonghua Wang

    Citation: BMC Systems Biology 2018 12:21

    Published on:

    The original article was published in BMC Systems Biology 2018 12:2

  21. Content type: Research article

    With the global emergence of multi-drug resistant strains of Mycobacterium tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics targeting potential human host factors.

    Authors: Zhang Wang, Seda Arat, Michal Magid-Slav and James R. Brown

    Citation: BMC Systems Biology 2018 12:3

    Published on:

  22. Content type: Research Article

    Dengue virus (DENV) is an increasing global health threat and associated with induction of both a long-lived protective immune response and immune-suppression. So far, the potency of treatment of DENV via anti...

    Authors: Mohamed Shahen, Zihu Guo, Akhtar Hussain Shar, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao and Yonghua Wang

    Citation: BMC Systems Biology 2018 12:2

    Published on:

    The Correction to this article has been published in BMC Systems Biology 2018 12:21

  23. Content type: Methodology Article

    Many mathematical models have now been employed across every area of systems biology. These models increasingly involve large numbers of unknown parameters, have complex structure which can result in substanti...

    Authors: Ian Vernon, Junli Liu, Michael Goldstein, James Rowe, Jen Topping and Keith Lindsey

    Citation: BMC Systems Biology 2018 12:1

    Published on:

Page 3 of 78

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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