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Systems physiology, pharmacology and medicine

Section edited by Christina Chan

This section covers the analysis and modeling of complex systems to better understand humans and animal biology, in particular with regard to human health and disease.

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  1. Abnormal synchronization of brain oscillations is found to be associated with various core symptoms of schizophrenia. However, the underlying mechanism of this association remains yet to be elucidated.

    Authors: Kyungchul Noh, Kyung Soon Shin, Dongkwan Shin, Jae Yeon Hwang, June Sic Kim, Joon Hwan Jang, Chun Kee Chung, Jun Soo Kwon and Kwang-Hyun Cho

    Citation: BMC Systems Biology 2013 7:30

    Content type: Research article

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  2. Cancer is a complex disease where molecular mechanism remains elusive. A systems approach is needed to integrate diverse biological information for the prognosis and therapy risk assessment using mechanistic a...

    Authors: Gaurav Kumar, Edmond J Breen and Shoba Ranganathan

    Citation: BMC Systems Biology 2013 7:12

    Content type: Research article

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  3. Palmitic acid, the most common saturated free fatty acid, has been implicated in ER (endoplasmic reticulum) stress-mediated apoptosis. This lipoapotosis is dependent, in part, on the upregulation of the activa...

    Authors: Hyunju Cho, Ming Wu, Linxia Zhang, Ryan Thompson, Aritro Nath and Christina Chan

    Citation: BMC Systems Biology 2013 7:9

    Content type: Research article

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  4. When mathematical modelling is applied to many different application areas, a common task is the estimation of states and parameters based on measurements. With this kind of inference making, uncertainties in ...

    Authors: Annette Krengel, Jan Hauth, Marja-Riitta Taskinen, Martin Adiels and Mats Jirstrand

    Citation: BMC Systems Biology 2013 7:8

    Content type: Methodology article

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  5. Lineage specific differentiation of human embryonic stem cells (hESCs) is largely mediated by specific growth factors and extracellular matrix molecules. Growth factors initiate a cascade of signals which cont...

    Authors: Shibin Mathew, Maria Jaramillo, Xinan Zhang, Li Ang Zhang, Alejandro Soto-Gutiérrez and Ipsita Banerjee

    Citation: BMC Systems Biology 2012 6:154

    Content type: Research article

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  6. Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor which raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol level, has been documented to in...

    Authors: Shengjun Fan, Qiang Geng, Zhenyu Pan, Xin Li, Lu Tie, Yan Pan and Xuejun Li

    Citation: BMC Systems Biology 2012 6:152

    Content type: Research article

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  7. 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE). These inflammatory signaling molecules play a role in the pathology of asthma and ...

    Authors: Tatiana A Karelina, Kirill V Zhudenkov, Oleg O Demin, Dmitry V Svetlichny, Balaji Agoram, David Fairman and Oleg V Demin

    Citation: BMC Systems Biology 2012 6:141

    Content type: Research article

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  8. Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy using selective estrogen receptor modulators (SERMs, such as tamoxifen). However,...

    Authors: Galina Lebedeva, Azusa Yamaguchi, Simon P Langdon, Kenneth Macleod and David J Harrison

    Citation: BMC Systems Biology 2012 6:138

    Content type: Research article

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  9. Estrogen therapy has positively impact the treatment of several cancers, such as prostate, lung and breast cancers. Moreover, several groups have reported the importance of estrogen induced gene regulation in ...

    Authors: Magbubah Essack, Cameron Ross MacPherson, Sebastian Schmeier and Vladimir B Bajic

    Citation: BMC Systems Biology 2012 6:135

    Content type: Research article

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  10. The activation of immune cells in the brain is believed to be one of the earliest events in prion disease development, where misfolded PrionSc protein deposits are thought to act as irritants leading to a seri...

    Authors: Isaac Crespo, Kirsten Roomp, Wiktor Jurkowski, Hiroaki Kitano and Antonio del Sol

    Citation: BMC Systems Biology 2012 6:132

    Content type: Research article

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  11. Global demographic changes have stimulated marked interest in the process of aging. There has been, and will continue to be, an unrelenting rise in the number of the oldest old ( >85 years of age). Together wi...

    Authors: Mark T Mc Auley, Darren J Wilkinson, Janette JL Jones and Thomas BL Kirkwood

    Citation: BMC Systems Biology 2012 6:130

    Content type: Research article

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  12. The genome is continuously attacked by a variety of agents that cause DNA damage. Recognition of DNA lesions activates the cellular DNA damage response (DDR), which comprises a network of signal transduction p...

    Authors: Rainer Poltz and Michael Naumann

    Citation: BMC Systems Biology 2012 6:125

    Content type: Research article

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  13. The search for new drug targets for antibiotics against Plasmodium falciparum, a major cause of human deaths, is a pressing scientific issue, as multiple resistance strains spread rapidly. Metabolic network-based...

    Authors: Susanna Bazzani, Andreas Hoppe and Hermann-Georg Holzhütter

    Citation: BMC Systems Biology 2012 6:118

    Content type: Methodology article

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  14. Annually, influenza A viruses circulate the world causing wide-spread sickness, economic loss, and death. One way to better defend against influenza virus-induced disease may be to develop novel host-based the...

    Authors: Jason E Shoemaker, Satoshi Fukuyama, Amie J Eisfeld, Yukiko Muramoto, Shinji Watanabe, Tokiko Watanabe, Yukiko Matsuoka, Hiroaki Kitano and Yoshihiro Kawaoka

    Citation: BMC Systems Biology 2012 6:117

    Content type: Research article

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  15. In the field of drug discovery, assessing the potential of multidrug therapies isa difficult task because of the combinatorial complexity (both theoretical andexperimental) and because of the requirements on t...

    Authors: Giuseppe Facchetti, Mattia Zampieri and Claudio Altafini

    Citation: BMC Systems Biology 2012 6:115

    Content type: Research article

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  16. Availability of oxygen and nutrients in the coronary circulation is a crucial determinant of cardiac performance. Nutrient composition of coronary blood may significantly vary in specific physiological and pat...

    Authors: Anja Karlstädt, Daniela Fliegner, Georgios Kararigas, Hugo Sanchez Ruderisch, Vera Regitz-Zagrosek and Hermann-Georg Holzhütter

    Citation: BMC Systems Biology 2012 6:114

    Content type: Research article

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  17. The use of biological molecular network information for diagnostic and prognostic purposes and elucidation of molecular disease mechanism is a key objective in systems biomedicine. The network of regulatory mi...

    Authors: Mohammed Alshalalfa, Gary D Bader, Anna Goldenberg, Quaid Morris and Reda Alhajj

    Citation: BMC Systems Biology 2012 6:112

    Content type: Methodology article

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  18. Extracellular feedback is an abundant module of intercellular communication networks, yet a detailed understanding of its role is still lacking. Here, we study interactions between polyclonal activated T cells...

    Authors: Yonatan Savir, Nir Waysbort, Yaron E Antebi, Tsvi Tlusty and Nir Friedman

    Citation: BMC Systems Biology 2012 6:111

    Content type: Research article

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  19. Embryonic stem cells (ESC) have the capacity to self-renew and remain pluripotent, while continuously providing a source of a variety of differentiated cell types. Understanding what governs these properties a...

    Authors: Vijay Chickarmane, Victor Olariu and Carsten Peterson

    Citation: BMC Systems Biology 2012 6:98

    Content type: Research article

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  20. Colon crypts, a single sheet of epithelia cells, consist of a periodic pattern of stem cells, transit-amplifying cells, and terminally differentiated cells that constantly renew and turnover. Experimental evid...

    Authors: Lei Zhang, Arthur D Lander and Qing Nie

    Citation: BMC Systems Biology 2012 6:93

    Content type: Research article

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  21. The process of drug discovery and development is time-consuming and costly, and the probability of success is low. Therefore, there is rising interest in repositioning existing drugs for new medical indication...

    Authors: Hee Sook Lee, Taejeong Bae, Ji-Hyun Lee, Dae Gyu Kim, Young Sun Oh, Yeongjun Jang, Ji-Tea Kim, Jong-Jun Lee, Alessio Innocenti, Claudiu T Supuran, Luonan Chen, Kyoohyoung Rho and Sunghoon Kim

    Citation: BMC Systems Biology 2012 6:80

    Content type: Research article

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  22. Proteolytic breakdown of the amyloid precursor protein (APP) by secretases is a complex cellular process that results in formation of neurotoxic Aβ peptides, causative of neurodegeneration in Alzheimer’s disea...

    Authors: Angelyn Lao, Vanessa Schmidt, Yvonne Schmitz, Thomas E Willnow and Olaf Wolkenhauer

    Citation: BMC Systems Biology 2012 6:74

    Content type: Research article

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  23. Integrating gene expression profiles and metabolic pathways under different experimental conditions is essential for understanding the coherence of these two layers of cellular organization. The network charac...

    Authors: Nikolaus Sonnenschein, José Felipe Golib Dzib, Annick Lesne, Sebastian Eilebrecht, Sheerazed Boulkroun, Maria-Christina Zennaro, Arndt Benecke and Marc-Thorsten Hütt

    Citation: BMC Systems Biology 2012 6:41

    Content type: Research article

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  24. The physical periphery of a biological cell is mainly described by signaling pathways which are triggered by transmembrane proteins and receptors that are sentinels to control the whole gene regulatory network...

    Authors: Ricardo de Matos Simoes, Shailesh Tripathi and Frank Emmert-Streib

    Citation: BMC Systems Biology 2012 6:38

    Content type: Research article

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  25. Understanding the information-processing capabilities of signal transduction networks, how those networks are disrupted in disease, and rationally designing therapies to manipulate diseased states require syst...

    Authors: Daniel C Kirouac, Julio Saez-Rodriguez, Jennifer Swantek, John M Burke, Douglas A Lauffenburger and Peter K Sorger

    Citation: BMC Systems Biology 2012 6:29

    Content type: Research article

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  26. Systems biology holds promise as a new approach to drug target identification and drug discovery against neglected tropical diseases. Genome-scale metabolic reconstructions, assembled from annotated genomes an...

    Authors: Arvind K Chavali, Anna S Blazier, Jose L Tlaxca, Paul A Jensen, Richard D Pearson and Jason A Papin

    Citation: BMC Systems Biology 2012 6:27

    Content type: Research article

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  27. Expression of the two transcription factors microphthalmia-associated transcription factor (MITF) and signal transducer and activator of transcription 3 (STAT3) are tightly connected to cell proliferation and ...

    Authors: Josef Thingnes, Timothy J Lavelle, Arne B Gjuvsland, Stig W Omholt and Eivind Hovig

    Citation: BMC Systems Biology 2012 6:11

    Content type: Research article

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  28. Toxins A and B (TcdA and TcdB) are Clostridium difficile's principal virulence factors, yet the pathways by which they lead to inflammation and severe diarrhea remain unclear. Also, the relative role of either to...

    Authors: Kevin M D'Auria, Gina M Donato, Mary C Gray, Glynis L Kolling, Cirle A Warren, Lauren M Cave, Michael D Solga, Joanne A Lannigan, Jason A Papin and Erik L Hewlett

    Citation: BMC Systems Biology 2012 6:2

    Content type: Research article

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  29. During respiratory viral infections host injury occurs due in part to inappropriate host responses. In this study we sought to uncover the host transcriptional responses underlying differences between high- an...

    Authors: Stewart T Chang, Nicolas Tchitchek, Debashis Ghosh, Arndt Benecke and Michael G Katze

    Citation: BMC Systems Biology 2011 5:202

    Content type: Research article

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  30. Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease with a varying range of phenotypes involving abnormal vasculature primarily manifested as arteriovenous malformations in various org...

    Authors: Neema Jamshidi, Franklin J Miller, Jess Mandel, Timothy Evans and Michael D Kuo

    Citation: BMC Systems Biology 2011 5:200

    Content type: Research article

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  31. Nutritional systems biology offers the potential for comprehensive predictions that account for all metabolic changes with the intricate biological organization and the multitudinous interactions between the c...

    Authors: Thanh-Phuong Nguyen, Marco Scotti, Melissa J Morine and Corrado Priami

    Citation: BMC Systems Biology 2011 5:195

    Content type: Research article

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  32. Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-me...

    Authors: Stacey D Finley, Marianne O Engel-Stefanini, PI Imoukhuede and Aleksander S Popel

    Citation: BMC Systems Biology 2011 5:193

    Content type: Research article

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  33. Cancer cells harbor a large number of molecular alterations such as mutations, amplifications and deletions on DNA sequences and epigenetic changes on DNA methylations. These aberrations may dysregulate gene e...

    Authors: Shyh-Dar Li, Tatsuaki Tagami, Ying-Fu Ho and Chen-Hsiang Yeang

    Citation: BMC Systems Biology 2011 5:186

    Content type: Research article

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  34. Hemostasis is a critical and active function of the blood mediated by platelets. Therefore, the prevention of pathological platelet aggregation is of great importance as well as of pharmaceutical and medical i...

    Authors: Gaby Wangorsch, Elke Butt, Regina Mark, Katharina Hubertus, Jörg Geiger, Thomas Dandekar and Marcus Dittrich

    Citation: BMC Systems Biology 2011 5:178

    Content type: Research article

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  35. Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors. If these stress responses are overwhelmed, this c...

    Authors: Walter K Schlage, Jurjen W Westra, Stephan Gebel, Natalie L Catlett, Carole Mathis, Brian P Frushour, Arnd Hengstermann, Aaron Van Hooser, Carine Poussin, Ben Wong, Michael Lietz, Jennifer Park, David Drubin, Emilija Veljkovic, Manuel C Peitsch, Julia Hoeng…

    Citation: BMC Systems Biology 2011 5:168

    Content type: Methodology article

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  36. As an important epigenetic modification, DNA methylation plays a crucial role in the development of mammals and in the occurrence of complex diseases. Genes that interact directly or indirectly may have the sa...

    Authors: Hui Liu, Jianzhong Su, Junhua Li, Hongbo Liu, Jie Lv, Boyan Li, Hong Qiao and Yan Zhang

    Citation: BMC Systems Biology 2011 5:158

    Content type: Research article

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  37. Neural stem cells offer potential treatment for neurodegenerative disorders, such like Alzheimer's disease (AD). While much progress has been made in understanding neural stem cell function, a precise descript...

    Authors: Luwen Zhang, Xiangchun Ju, Yumin Cheng, Xiuyun Guo and Tieqiao Wen

    Citation: BMC Systems Biology 2011 5:152

    Content type: Research article

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  38. Ciliary dysfunction leads to a number of human pathologies, including primary ciliary dyskinesia, nephronophthisis, situs inversus pathology or infertility. The mechanism of cilia beating regulation is complex...

    Authors: Nikolay V Kotov, Declan G Bates, Antonina N Gizatullina, Bulat Gilaziev, Rustem N Khairullin, Michael ZQ Chen, Ignat Drozdov, Yoshinori Umezawa, Christian Hundhausen, Alexey Aleksandrov, Xing-gang Yan, Sarah K Spurgeon, C Mark Smales and Najl V Valeyev

    Citation: BMC Systems Biology 2011 5:143

    Content type: Research article

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  39. Complex phenotypes such as insulin resistance involve different biological pathways that may interact and influence each other. Interpretation of related experimental data would be facilitated by identifying r...

    Authors: Thomas Kelder, Lars Eijssen, Robert Kleemann, Marjan van Erk, Teake Kooistra and Chris Evelo

    Citation: BMC Systems Biology 2011 5:127

    Content type: Research article

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  40. Successful drug development has been hampered by a limited understanding of how to translate laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for pr...

    Authors: Robert Kleemann, Svetlana Bureeva, Ally Perlina, Jim Kaput, Lars Verschuren, Peter Y Wielinga, Eva Hurt-Camejo, Yuri Nikolsky, Ben van Ommen and Teake Kooistra

    Citation: BMC Systems Biology 2011 5:125

    Content type: Research article

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  41. One of the primary objectives in cancer research is to identify causal genomic alterations, such as somatic copy number variation (CNV) and somatic mutations, during tumor development. Many valuable studies la...

    Authors: Linh M Tran, Bin Zhang, Zhan Zhang, Chunsheng Zhang, Tao Xie, John R Lamb, Hongyue Dai, Eric E Schadt and Jun Zhu

    Citation: BMC Systems Biology 2011 5:121

    Content type: Research article

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  42. Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattract...

    Authors: Pernille Yde, Benedicte Mengel, Mogens H Jensen, Sandeep Krishna and Ala Trusina

    Citation: BMC Systems Biology 2011 5:115

    Content type: Research article

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2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)

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